[1]何伟华,独建库,张明德,等. 介入性热灌注联合瘤体注射热碘油对兔VX2肝癌模型的疗效研究[J].介入放射学杂志,2013,(11):940-942.
　HE Wei? hua,DU Jian? ku,ZHANG Ming? de,et al.The therapeutic effect of interventional heated?蛳 Lipiodol perfusion combined with heated?蛳 Lipiodol injection into tumor for the treatment of VX2 liver cancer in experimental rabbits[J].journal interventional radiology,2013,(11):940-942.
点击复制

 介入性热灌注联合瘤体注射热碘油对兔VX2肝癌模型的疗效研究 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年11期
页码:
940-942
栏目:
实验研究
出版日期:
2013-11-15

文章信息/Info

Title:
The therapeutic effect of interventional heated?蛳 Lipiodol perfusion combined with heated?蛳 Lipiodol injection into tumor for the treatment of VX2 liver cancer in experimental rabbits
作者:
 何伟华;  独建库;  张明德;  邹 洋;  马小桔
Author(s):
 HE Wei?蛳 hua;  DU Jian?蛳 ku;  ZHANG Ming?蛳 de;  ZOU Yang;  MA Xiao?蛳 ju.
 Interventional Center， No.150 Hospital of PLA， Luoyang， Henan Province 471031， China
关键词:
 ; 【关键词】 肝肿瘤;  热碘油;  动物实验
文献标志码:
A
摘要:
 【摘要】 目的 观察介入性灌注热碘油联合瘤体注射热碘油对兔VX2肝癌模型的疗效及安全性。方法 将VX2肝癌细胞接种于30只新西兰白兔肝内，制备肝VX2模型。将动物随机分为实验组和对照组，每组15只。实验组肝动脉灌注联合经皮穿刺瘤内注射60℃热碘油3 ml，对照组经肝动脉灌注常温25℃碘油3 ml。用B超观察栓塞前后瘤体大小，采血查血清丙氨酸转氨酶（ALT）水平。结果 实验组肿瘤体积由（1 565 ± 315）mm3缩小至（1 054 ± 463）mm3；对照组肿瘤体积由（1 568 ± 323）mm3缩小至（1 275 ± 472）mm3，组间差异有统计学意义（P ＜ 0.05）。实验组血清ALT从（736 ± 212）u/L增至（816 ± 247）u/L，对照组从（745 ± 215）u/L增至（796 ± 236）u/L，组间差异无统计学意义（P ＞ 0.05）。结论 介入性灌注热碘油联合瘤体注射热碘油对兔VX2肝癌模型有更强的抑制作用。 

参考文献/References:

 ［1］ 曹 玮， 张洪新， 万 毅， 等． 温热（60℃）化疗栓塞对肝癌患者红细胞免疫功能的影响［J］． 临床放射学杂志， 2008， 27： 1255 ?蛳 1257．
［2］ Tabaru K， Konno T， Oda T， et al. Treatment of VX2 carcinoma implanted in the liver with arterial and intraperitoneal administration of oily anticancer agents［J］. Cancer Chemother Pharmacol， 2001， 47： 149 ?蛳 154.
［3］ 杨永波， 程红岩． 肝动脉化疗栓塞治疗中碘油用量的现状与研究进展［J］． 介入放射学杂志， 2012， 21： 348 ?蛳 352．
［4］ Maeda T， Kuramoto S， Shimojima Y， et al. Basic studies of intra?蛳 arterial hyperthermic treatment［J］. Gan To Kagaku Ryoho， 1992， 19： 1667 ?蛳 1670.
［5］ 李广琪， 曹 玮， 李 超， 等． 肝动脉热灌注对兔肝VX2肿瘤及正常肝组织血管渗透性功能的作用［J］． 介入放射学杂志，2010， 19： 217 ?蛳 219．
［6］ 曹 玮， 王执民， 张洪新， 等． 兔VX2肝癌阿霉素热碘油栓塞的疗效观察［J］． 临床放射学杂志， 2004， 23： 438 ?蛳 440．
［7］ 梁志会， 王执民， 张洪新， 等． 经皮肝动脉介入性热疗对犬肝功的影响［J］． 第四军医大学学报， 2000， 21： 430 ?蛳 432．

相似文献/References:

[1]张 琳,黄学全,王健,等.自主研发电化学治疗同轴电极与传统针式电极电解效应的对比研究[J].介入放射学杂志,2012,(02):148.
　ZHANG Lin,HUANG Xue-quan,WANG Jian,et al.The electrolytic effect in electrochemotherapy: a comparative study between self-prepared coaxial electrode and conventional needle electrode[J].journal interventional radiology,2012,(11):148.
[2]赵 玮,王伟中,陈莹,等.耳部动静脉畸形供血动脉的血管造影研究[J].介入放射学杂志,2012,(02):103.
　ZHAO Wei,WANG Wei-zhong,CHEN Ying,et al.Angiographic findings of the feeding arteries of auricular arteriovenous malformations[J].journal interventional radiology,2012,(11):103.
[3]邹俊民,龙世娟,张振明. 改良髂内动脉化疗联合放疗治疗Ⅲ~Ⅳa期 子宫颈癌32例[J].介入放射学杂志,2012,(02):123.
　ZOU Jun-min,LONG Shi-Juan,ZHANG Zheng-ming..Improved internal iliac artery chemotherapy combined with radiotherapy for the treatment of stage Ⅲ-Ⅳa cervical cancers[J].journal interventional radiology,2012,(11):123.
[4]王昌明,李 选,宋世兵,等.肝门部胆道引流管折叠技术在肝移植后胆道非吻合口狭窄治疗中的应用[J].介入放射学杂志,2012,(02):136.
　WANG Chang-ming,LI Xuan,SONG Shi-bing,et al.The application of biliary catheter folding technique in the treatment of hilar nonanastomotic biliary strictures after orthotopic liver transplantation[J].journal interventional radiology,2012,(11):136.
[5]赵玉峰,孙玉琴,韩晓静,等. 输卵管介入再通术后受孕时机的研究[J].介入放射学杂志,2012,(02):158.
　ZHAO Yu-feng,SUN Yu-qin,HAN Xiao-jing,et al.The optimal time for conception after fallopian tube recanalization therapy[J].journal interventional radiology,2012,(11):158.
[6]含 笑,曹建民,史东宏,等.吉西他滨、顺铂动静脉联合化疗治疗晚期非小细胞肺癌的近期疗效分析[J].介入放射学杂志,2012,(02):119.
　HAN Xiao,CAO Jian-min,SHI Dong-hong,et al.Bronchial artery infusion of Gemcitabine and Cisplatin combined with systemic chemotherapy for advanced non-small cell lung cancer: its short-term efficacy[J].journal interventional radiology,2012,(11):119.
[7]姚雪松,李 槐.不可手术切除的肝细胞癌的疗效评价标准——改良ＲＥＣＩＳＴ标准更可靠[J].介入放射学杂志,2012,(03):177.
　. Ｔｈｅｒａｐｅｕｔｉｃ ｅｖａｌｕａｔｉｏｎ ｃｒｉｔｅｒｉｏｎ ｏｆ ｉｎｏｐｅｒａｂｌｅ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ｍｏｄｉｆｉｅｄ ＲＥＣＩＳＴ ａｓ ａ ｍｏｒｅ ｒｅｌｉａｂｌｅ ｓｔａｎｄａｒｄ[J].journal interventional radiology,2012,(11):177.
[8]齐 立,李慎茂,俸军林,等. 动脉溶栓与机械碎栓联合动脉溶栓的对比分析[J].介入放射学杂志,2012,(03):180.
　,,et al. Ｃｏｍｐａｒｉｓｏｎ ｏｆ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｉｃａｃｙ ｂｅｔｗｅｅｎ ｓｉｍｐｌｅ ａｒｔｅｒｉａｌ ｔｈｒｏｍｂｏｌｙｓｉｓ ａｎｄ ｍｅｃｈａｎｉｃａｌ ｔｈｒｏｍｂｅｃｔｏｍｙ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ａｒｔｅｒｉａｌ ｔｈｒｏｍｂｏｌｙｓｉｓ ｆｏｒ ａｃｕｔｅ ｃｅｒｅｂｒａｌ ｉｎｆａｒｃｔｉｏｎ ａｔ ｉｔｓ ｕｌｔｒａｅａｒｌｙ ｓｔａｇｅ[J].journal interventional radiology,2012,(11):180.
[9]石 潆,赵 卫,沈 进,等.脑动静脉畸形栓塞治疗术并发颅内出血的原因及处理[J].介入放射学杂志,2012,(03):185.
　,,et al.Ｉｎｔｒａｃｒａｎｉａｌ ｈｅｍｏｒｒｈａｇｅ ｄｕｅ ｔｏ ｅｍｂｏｌｉｚａｔｉｏｎ ｔｈｅｒａｐｙ ｆｏｒ ｃｅｒｅｂｒａｌ ａｒｔｅｒｉｏｖｅｎｏｕｓ ｍａｌｆｏｒｍａｔｉｏｎ： ｉｔｓ ｃａｕｓｅｓ ａｎｄ ｍａｎａｇｅｍｅｎｔ [J].journal interventional radiology,2012,(11):185.
[10]周 慷,李晓光,金征宇,等.清宫术前子宫动脉化疗栓塞术治疗瘢痕妊娠的疗效分析[J].介入放射学杂志,2012,(03):190.
　,,et al.Ｔｈｅｒａｐｅｕｔｉｃ ａｎａｌｙｓｉｓ ｏｆ ｂｉｌａｔｅｒａｌ ｕｔｅｒｉｎｅ ａｒｔｅｒｙ ｃｈｅｍｏｅｍｂｏｌｉｚａｔｉｏｎ ｐｅｒｆｏｒｍｅｄ ｂｅｆｏｒｅ ｕｔｅｒｉｎｅ ｄｉｌａｔｉｏｎ ａｎｄ ｃｕｒｅｔｔａｇｅ ｆｏｒ ｃｅｓａｒｅａｎ ｓｃａｒ ｐｒｅｇｎａｎｃｙ [J].journal interventional radiology,2012,(11):190.
[11]杜 鲲,管 生,胡小波,等. 原发性肝癌ＴＡＣＥ术后完全缓解病灶磁共振 ＡＤＣ值可重复性及一致性研究[J].介入放射学杂志,2011,(11):867.
　DU Kun,GUAN Sheng,HU Xiao-bo,et al.Magnetic resonance apparent diffusion coefficient values of the completely remitted lesions of primary hepatocellular carcinoma after TACE: a study of their repeatability and consistency[J].journal interventional radiology,2011,(11):867.
[12]李建军,郑加生,崔雄伟,等. 肝肿瘤CT引导经皮射频消融术后胆道并发症防治[J].介入放射学杂志,2011,(12):984.
　LI Jian-jun,ZHENG Jia-sheng,CUI Xiong-wei,et al.The prevention and treatment of biliary complications occurred after CT-guided percutaneous radiofrequency ablation for hepatic neoplasms[J].journal interventional radiology,2011,(11):984.
[13]张学彬,花迎雪,仇晓霞,等. 肝动脉臭氧化碘油栓塞治疗兔VX2肝癌的初步研究[J].介入放射学杂志,2012,(09):760.
　ZHANG Xue- bin,HUA Ying-xue,QIU Xiao- xia,et al. A preliminary study of hepatic arterial embolization with ozonated?蛳 Lipiodol for liver VX2 carcinoma in experimental rabbits[J].journal interventional radiology,2012,(11):760.
[14]陈长广,倪才方,陈 珑. 肝动脉栓塞联合射频消融对兔肝癌模型VEGF及MVD的影响[J].介入放射学杂志,2013,(11):936.
　CHEN Chang? guang,NI Cai? fang,CHEN Long.. Effect of transcatheter arterial chemoembolization together with radiofrequency ablation on VEGF and MVD in rabbit models with hepatic cancer[J].journal interventional radiology,2013,(11):936.
[15]曾昭吝,蔡明岳,黄文薮,等.肝动脉化疗栓塞术后胆汁瘤形成63例临床分析[J].介入放射学杂志,2013,(12):989.
　ZENG Zhao? lin,CAI Ming? yue,HUANG Wen? sou,et al. The formation of intrahepatic biloma after transcatheter arterial chemoembolization： a clinical analysis of 63 cases[J].journal interventional radiology,2013,(11):989.
[16]钱 亭,陈茂振,高 峰,等. 两种方法建立兔VX2肝癌模型的比较及影像学评估[J].介入放射学杂志,2014,(01):58.
　QIAN Ting,CHEN Mao? zhen,GAO Feng,et al. Comparison of two methods used in establishing VX?蛳 2 liver tumor model in rabbits and their imaging evaluation[J].journal interventional radiology,2014,(11):58.
[17]徐守军,杜端明,刘鹏程,等. 肝肿瘤射频消融术后CT表现及其临床意义[J].介入放射学杂志,2014,(01):69.
　XU Shou? jun,DU Duan? ming,LIU Peng? cheng,et al. CT manifestation and its clinical significance of liver tumors after radiofrequency ablation[J].journal interventional radiology,2014,(11):69.
[18]陈文会,杨朝爱,杨继金,等. 曲马多在经皮穿刺肝肿瘤射频消融术中的应用[J].介入放射学杂志,2014,(02):126.
　CHEN Wen? hui,YANG Chao? ai,YANG Ji? jin,et al. Application of tramadol in performing percutaneous radiofrequency ablation for liver neoplasms[J].journal interventional radiology,2014,(11):126.
[19]陈敏华. 超声引导肝肿瘤消融治疗的历史、现状及问题[J].介入放射学杂志,2014,(06):463.
　CHEN Min- hua. Ultrasound- guided hepatic tumor ablation： history， current situation and clinical issues[J].journal interventional radiology,2014,(11):463.

备注/Memo

备注/Memo:
（收稿日期：２０１3-０4-2０） 
更新日期/Last Update: