[1]徐 阳,臧 爽,陈路锋,等.Logistic回归及ROC曲线综合评价血生化指标对肝癌TACE术后发热的预测价值 [J].介入放射学杂志,2013,(06):513-517.
　XU Yang,ZANG Shuang,CHEN Lu? feng,et al. Combination evaluation of plasma biochemical indexes with Logistic regression and ROC analysis in predicting hyperthermia after transcatheter hepatic arterial chemoembolization for liver cancer[J].journal interventional radiology,2013,(06):513-517.
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Logistic回归及ROC曲线综合评价血生化指标对肝癌TACE术后发热的预测价值 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年06期
页码:
513-517
栏目:
护理论坛
出版日期:
2013-06-24

文章信息/Info

Title:
 Combination evaluation of plasma biochemical indexes with Logistic regression and ROC analysis in predicting hyperthermia after transcatheter hepatic arterial chemoembolization for liver cancer
作者:
徐 阳;  臧 爽;  陈路锋;  徐 克
Author(s):
XU Yang;  ZANG Shuang;  CHEN Lu?蛳 feng;  XU Ke.
Department of Radiology， the First Affiliated Hospital， China Medical University， Shenyang 110001， China

关键词:
 ; 【关键词】 肝癌;  Logistic回归;  曲线;  介入治疗;  化疗栓塞;  发热
文献标志码:
A
摘要:
 【摘要】 目的 研究肝癌经导管肝动脉化疗栓塞术（TACE）后发热的相关因素及其与发热程度、持续时间的关系，探讨Logistic回归及ROC曲线评价血生化指标对肝癌THACE术后发热预测价值。方法 回顾分析232例肝癌患者行304次TACE术前术后的实验室数据，并对其进行有序Logistic回归分析，使用受试者工作特征（ROC）曲线评估剂量学参数的预测性能和最佳诊断界值。结果 按照发热程度（不发热 < 37.0℃、低热37.0℃ ~ 37.9℃、中等热38.0℃ ~ 38.9℃、高热 ＞ 39℃）分组后各组患者的住院天数、碘油剂量，术前血清钠、尿素、肌酐，术后血液粒细胞、白蛋白、血清钠、尿素、肌酐存在显著差异（P < 0.05）；有序Logistic回归分析，患者TACE术前血尿素、术后粒细胞比率、术后血小板对患者术后发热具有影响；ROC曲线分析术前血尿素的临界值是4.965 mmol/L，对于术后发热具有良好的预测性；碘油剂量与发热程度、发热程度与住院天数以及发热持续天数有显著相关性（P < 0.05）。结论 TACE术前血尿素、术后血小板与术后发热负相关，术后粒细胞比率与术后发热正相关。术前血尿素在诊断TACE术后发热中具有较高的灵敏度和特异度，可以作为发热的预测指标。

参考文献/References:

 ［1］ Berger DH， Carrasco CH， Hohn DC， et al. Hepatic chemoem?蛳 bolization or embolization for primary or metastatic liver tumor：post?蛳 treatment management and complications［J］. J Surg Oncol， 1995， 60： 116 ?蛳 121.
［2］ 李麟荪， 滕皋军． 介入放射学临床与并发症［M］． 北京： 人民卫生出版社， 2010： 432．
［3］ 韩鹏飞，张劲松. 中晚期肝癌介入治疗后常见近期并发症的meta分析［J］. 上海预防医学杂志， 2007， 19： 517 ?蛳 518.
［4］ 张建国． ROC曲线分析的基本原理以及在体质与健康促进研究中的应用［J］． 体育科学， 2008， 28： 62 ?蛳 66．
［5］ 王江云， 李彦豪， 卢 伟， 等． 肝癌TACE治疗后发热影响因素分析［J］． 南方医科大学学报， 2007， 27： 1417 ?蛳 1418． 

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 （收稿日期：２０１3-０1-29）
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