[1]胡 萍,司同国,郭 志.血清高迁移率族蛋白B1检测在T3N0M0期前列腺癌冷冻治疗后复发中的意义[J].介入放射学杂志,2013,(04):298-300.
 HU Ping,SI Tong? guo,GUO Zhi..The significance of serum HMGB1 in forecasting the recurrence of stage T3N0M0 prostate cancer after cryotherapy[J].journal interventional radiology,2013,(04):298-300.
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血清高迁移率族蛋白B1检测在T3N0M0期前列腺癌冷冻治疗后复发中的意义()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年04期
页码:
298-300
栏目:
肿瘤介入
出版日期:
2013-04-17

文章信息/Info

Title:
The significance of serum HMGB1 in forecasting the recurrence of stage T3N0M0 prostate cancer after cryotherapy
作者:
胡 萍 司同国 郭 志
Author(s):
HU Ping SI Tong?蛳 guo GUO Zhi.
Department of Interventional Therapy, Affiliated Tumor Hospital of Tianjin Medical University, Tianjin Municipal Key Laboratory of Cancer Prevention and Treatment, Tianjin 300060, China
关键词:
【关键词】 前列腺癌 复发 转移 高迁移率族蛋白B1 肿瘤标记
文献标志码:
A
摘要:
【摘要】 目的 探讨血清高迁移率族蛋白B1(HMGB1)预测T3N0M0期前列腺癌冷冻治疗后复发的临床意义。方法 收集65例T3期前列腺癌患者(PCa组)和30例前列腺良性增生患者(BPH组)的血清样本,应用酶联免疫吸附试验测定血清HMGB1水平;PCa组患者均行经皮穿刺冷冻消融治疗,术后随访外周血前列腺特异抗原(PSA)、前列腺MRI,可疑复发者行病理穿刺活检证实。比较PCa组患者血清HMGB1水平。结果 术前血清HMGB1在PCa组为(55.28 ± 29.37)ng/ml,明显高于BPH组的(34.61 ± 13.15)ng/ml(P = 0.004)。PCa组患者冷冻治疗后,无复发46例,局部复发15例,远处转移4例,三者术前HMGB1平均值分别为(55.49 ± 7.12)ng/ml、(73.13 ± 7.89)ng/ml和(94.23 ± 17.91)ng/ml,差异有统计学意义(P < 0.01)。结论 术前血清HMGB1水平高的PCa患者冷冻治疗后复发、转移率较高,血清HMGB1的检测可为冷冻治疗后复发性前列腺癌的诊断提供重要临床价值。

参考文献/References:

[1] Tanaka N, Fujimoto K, Hirayama A, et al. Trends of the primary therapy for patients with prostate Cancer in Nara uro?蛳 oncological research group (NUORG): a comparison between the CaPSURE data and the NUORG data[J]. Jpn J Clin Oncol, 2010, 40: 588 ?蛳 592.[2] Lian H, Guo H, Gan W, et al. Cryosurgery as primary treatment for localized prostate Cancer[J]. Int Urol Nephrol, 2011, 43: 1089 ?蛳 1094.[3] Ishiguro H, Nakaigawa N, Miyoshi Y, et al. Receptor for advanced glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate Cancer development[J]. Prostate, 2005, 64: 92 ?蛳 100.[4] 郭 志. 关注冷冻消融治疗前列腺癌的若干问题[J]. 中华医学杂志, 2010, 84: 2959 ?蛳 2961.[5] 郭 志, 王海涛, 邢文阁, 等. 冷冻消融治疗T3N0M0期前列腺癌的初步临床观察[J]. 中华医学杂志, 2004, 90: 2815 ?蛳 2819.[6] 朱 刚, 刘 明, 万 奔, 等. 早期前列腺癌的诊断和治疗[J]. 中华男科学杂志, 2005, 11: 693 ?蛳 696.[7] Kuban DA, Levy LB, Potters L, et al. Comparison of biochemi?蛳 cal failure definitions for permanent prostate brachytherapy[J]. Int J Radiat Oncol Biol Phys, 2006, 65: 1487 ?蛳 1493.[8] Kuniyasu H, Chihara Y, Kondo H, et al. Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate Cancer[J]. Oncol Rep, 2003, 10: 1863 ?蛳 1868.[9] Chen J, Liu X, Zhang J, et al. Targeting HMGB1 inhibits ovarian Cancer growth and metastasis by lentivirus?蛳 mediated RNA interference[J] J Cell Physiol, 2012, 227: 3629 ?蛳 3638.[10] Lee H, Song M, Shin N, et al. Diagnostic significance of serum HMGB1 in colorectal carcinomas[J]. PLoS One, 2012, 7: e34318.[11] Li T, Gui Y, Yuan T, et al. Overexpression of high mobility group box 1 with poor prognosis in patients after radical prostatectomy[J]. BJU Int, 2012, 110: e1125 ?蛳 1130.

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备注/Memo

备注/Memo:
(收稿日期:2012-11-12)
更新日期/Last Update: