[1]高力明,宗书峰,游晓华,等. 卵圆孔未闭动物模型的制备[J].介入放射学杂志,2012,(12):1011-1014.
 GAO Li? ming,ZONG Shu? feng,YOU Xiao? hua,et al. The preparation of patent foramen ovale model in dogs[J].journal interventional radiology,2012,(12):1011-1014.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年12期
页码:
1011-1014
栏目:
实验研究
出版日期:
2012-12-25

文章信息/Info

Title:
 The preparation of patent foramen ovale model in dogs
作者:
 高力明 宗书峰 游晓华 徐荣良 秦永文
Author(s):
 GAO Li?蛳 ming ZONG Shu?蛳 feng YOU Xiao?蛳 hua XU Rong?蛳 liang QIN Yong?蛳 wen.
 Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
关键词:
 【关键词】 卵圆孔未闭 房间隔穿刺 动物模型 实验研究
文献标志码:
A
摘要:
 【摘要】 目的 探讨采用经皮房间隔穿刺和球囊扩张法制备犬卵圆孔未闭(patent foramen ovale,PFO)动物模型的可行性。方法 采用22只健康成年犬,经皮房间隔卵圆窝穿刺、球囊扩张术制备犬PFO模型,对其中2只犬的卵圆窝穿刺点进行病理学等检查。结果 22只犬均成功进行房间隔卵圆窝穿刺和球囊扩张术,右房造影可见对比剂由右房进入左房,成功建立了犬PFO模型。完成房间隔卵圆窝穿刺及球囊扩张平均用时(25.1 ± 5.1)min,X线曝光时间平均(5.8 ± 1.6)min。穿刺前右心房平均压为(1.9 ± 0.8)mmHg,穿刺后测得左心房平均压为(2.5 ± 0.7)mmHg。对2只犬的心脏大体观察见心包膜完整;房间隔卵圆窝缺损分别为5 mm × 6 mm和6 mm × 6 mm,缺损周边均见少量淤血,未见血栓附着,余心内膜均完整。结论 经皮穿刺犬的房间隔卵圆窝、球囊扩张方法制备PFO模型可行。 

参考文献/References:

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备注/Memo

备注/Memo:
 (收稿日期:2012-06-02)
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