[1]贺克武,高 斌,秦汉林,等. 125I粒子组织间植入联合支气管动脉灌注化疗治疗肺癌的疗效观察[J].介入放射学杂志,2012,(07):554-558.
 HE Ke- wu,GAO Bin,QIN Han- lin,et al.CT?蛳 guided percutaneous 125I seed implantation combined with bronchial arterial infusion chemotherapy for lung cancers: observation of therapeutic efficacy[J].J Intervent Med,2012,(07):554-558.
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 125I粒子组织间植入联合支气管动脉灌注化疗治疗肺癌的疗效观察 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年07期
页码:
554-558
栏目:
肿瘤介入
出版日期:
2012-07-30

文章信息/Info

Title:
CT?蛳 guided percutaneous 125I seed implantation combined with bronchial arterial infusion chemotherapy for lung cancers: observation of therapeutic efficacy
作者:
 贺克武;  高 斌;  秦汉林;  李劲松;  黄永翠;  张宇东;  彭晓正;  汪 涛;  杨会军;  陈 昊
Author(s):
 HE Ke- wu;  GAO Bin;  QIN Han- lin;  LI Jin- song;  HUANG Yong- cui;  ZHANG Yu- dong;  PENG Xiao- zheng;  WANG Tao;  YANG Hui- jun;  CHEN Hao.
  Medical Imaging Center, Hefei Municipal First People’s Hospital, Hefei 230061, China
关键词:
 ; 【关键词】 肺癌;  碘放射性核素;  近距离放疗;  介入治疗
文献标志码:
A
摘要:
 【摘要】 目的 评价CT导引下125I粒子组织间植入联合经支气管动脉灌注化疗治疗进展期肺癌的疗效和安全性。方法 108例Ⅲ ~ Ⅳ期肺癌患者随机分为联合治疗组和灌注化疗组,联合治疗组43例57个病灶接受CT导引下125I放射性粒子植入后,联合同步支气管动脉内吉西他滨和奥沙利铂(GP)方案灌注化疗2 ~ 4个周期;灌注化疗组65例患者74个病灶仅接受支气管动脉内GP方案化疗2 ~ 4个周期,比较两组患者的疗效和不良反应发生率。结果 联合治疗组和灌注化疗组1、3、6、12个月的总缓解率分别为8.8%、56.1%、63.6%、84.0%和2.7%、21.%、41.9%、45.1%,组间差异有统计学意义(P < 0.01或P < 0.05)。联合治疗组和灌注化疗组1年累计生存率分别为91%和65%,中位生存时间分别为533 d和422 d,差异有统计学意义( P < 0.05)。CT导引下125I粒子植入的主要并发症为气胸、咯血、放射性粒子游走和胸腔积血,灌注化疗主要的不良反应为骨髓抑制和胃肠道反应等,患者可以耐受,联合治疗组和灌注化疗组患者各化疗不良反应的总发生率差异均无统计学意义(P > 0.05)。结论 CT导引下125I粒子组织间植入联合经支气管动脉灌注化疗治疗肺癌是一种安全、有效、微创的治疗方法。

参考文献/References:

[1]   万智勇, 顾文权, 叶贤德, 等. 血管内介入治疗老年晚期非小细胞肺癌的临床研究[J]. 临床放射学杂志, 2010, 29: 1238 ?蛳 1240.
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[3]   陈世壮, 张波绪, 方晓敏, 等. 125I放射性粒子植入联合吉西他滨顺铂方案治疗老年非小细胞肺癌[J]. 介入放射学杂志,2008, 17: 197 ?蛳 199.
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[5]   Zhang S, Zheng Y, Yu P, et al. The combined treatment of CT-guided percutaneous 125I seed implantation and chemotherapy for non?蛳small?蛳 cell lung Cancer[J]. J Cancer Res Clin Oncol, 2011, 137: 1813 ?蛳 1822.
[6]   艾小红, 翟福林. 支气管灌注化疗对局部晚期非小细胞肺癌远期疗效的回顾性分析[J]. 海南医学, 2008, 19: 25 ?蛳 27.
[7]  Lee W, Daly BD, Dipetrillo TA, et al. Limited resection for non?蛳 small cell lung Cancer: observed local control with implantation of I?蛳 125 brachytherapy seeds[J]. Ann Thorac Surg, 2003, 75: 237 ?蛳 242.
[8]  Koshiishi H, Takahashi E, Koseki K, et al. Evaluation of bronchial arterial infusion (BAI) for lung Cancer with carcinomatous pleuritis[J]. Gan To Kagaku Ryoho, 2007, 34: 2068 ?蛳 2070.

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备注/Memo

备注/Memo:
 (收稿日期:2011-02-14)
更新日期/Last Update: