[1]宋 琦,刘 玉,胡曙东,等.磁共振弥散加权成像在125I粒子组织间植入治疗胰腺癌疗效评估中的应用[J].介入放射学杂志,2012,(06):492-497.
　SONG Qi,LIU Yu,HU Shu-dong,et al. The application of MR diffusion-weighted imaging in evaluating the efficacy of 125I seed interstitial brachytherapy for pancreatic carcinomas： an experimental study in vivo[J].journal interventional radiology,2012,(06):492-497.
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磁共振弥散加权成像在125I粒子组织间植入治疗胰腺癌疗效评估中的应用 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年06期
页码:
492-497
栏目:
实验研究
出版日期:
2012-06-30

文章信息/Info

Title:
 The application of MR diffusion-weighted imaging in evaluating the efficacy of 125I seed interstitial brachytherapy for pancreatic carcinomas： an experimental study in vivo
作者:
 宋 琦;  刘 玉;  胡曙东;  黄 蔚;  王忠敏;  陈克敏;  严福华;  田建明
Author(s):
 SONG Qi;  LIU Yu;  HU Shu-dong;  HUANG Wei;  WANG Zhong- min;  CHEN Ke- min;  YAN Fu- hua;  TIAN Jian-ming.
 Department of Radiology， Changhai Hospital， the Second Military Medical University， Shanghai 200433， China
关键词:
 ; 【关键词】 胰腺癌;  125I粒子;  短距离放疗;  磁共振
文献标志码:
A
摘要:
 【摘要】 目的 探讨磁共振（MRI）弥散加权（DWI）成像对125I粒子组织间植入治疗人胰腺癌裸鼠移植瘤疗效的评估价值。方法 将人胰腺癌SW1990细胞株接种于BABL/C裸鼠右下肢旁腹股沟区偏背侧皮下，待瘤体长至8 ～ 10 mm进行干预，共有16只裸鼠的成瘤大小适用于实验，分为实验组8只，植入125I粒子，和对照组8只，植入空载粒子。粒子植入前及治疗后2周和2个月时分别行MRI常规扫描及DWI成像。取瘤体标本行组织病理学检查。结果 实验组肿瘤细胞坏死明显，而对照组肿瘤细胞无明显或有少许坏死。裸鼠心、肝、肺、肾及脾脏等组织无明显放射炎症表现。常规MRI成像评价125I粒子治疗胰腺癌疗效的价值有限。DWI显示实验组内整个肿瘤组织的表观弥散系数（ADC）值在治疗前为（0.001 15 ± 0.000 13） mm2/s，治疗后2周为（0.001 29 ± 0.000 038） mm2/s，治疗后2个月为（0.002 08 ± 0.000 14 ）mm2/s，与治疗前相比差异有统计学意义（P < 0.05）。实验组肿瘤实质区的ADC值亦较治疗前及对照组增高，但低于坏死区ADC值。结论 125I粒子组织间植入治疗人胰腺癌裸鼠移植瘤可导致肿瘤坏死，并对周围脏器是安全的。用常规MRI及DWI成像观察裸鼠皮下移植瘤可行。DWI对疗效评估有重要价值。

参考文献/References:

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 （收稿日期：２０１2-０2-29）
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