[1]李奋强,李 立,王文辉,等.氩氦刀或唑来膦酸单用及联合应用治疗骨转移癌疼痛对照研究[J].介入放射学杂志,2012,(06):482-485.
 LI Fen- qiang,LI Li,WANG Wen- hui,et al. Separate use or combined use of cryoablation and zoledronic acid for the treatment of pain caused by bone metastases: a comparative study[J].journal interventional radiology,2012,(06):482-485.
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氩氦刀或唑来膦酸单用及联合应用治疗骨转移癌疼痛对照研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年06期
页码:
482-485
栏目:
非血管介入
出版日期:
2012-06-30

文章信息/Info

Title:
 Separate use or combined use of cryoablation and zoledronic acid for the treatment of pain caused by bone metastases: a comparative study
作者:
 李奋强 李 立 王文辉 苏东君 常耀文 何学文 郭 刚 李明祥 李宝华
Author(s):
 LI Fen- qiang LI Li WANG Wen- hui SU Dong- jun CHANG Yao-wen HE Xue- wen GUO Gang LI Ming- xiang LI Bao- hua.
 Department of Interventional Therapy Combining Traditional Chinese and Western Medicine, the First Hospital, Lanzhou University, Lanzhou 730000, China
关键词:
 【 关键词】 骨转移癌 氩氦刀 唑来膦酸 疼痛
文献标志码:
A
摘要:
 【 摘要】 目的 比较氩氦刀或唑来膦酸单一治疗和联合治疗骨转移癌疼痛的疗效和安全性。方法 84例患者随机分为A组(联合)、B组(氩氦刀)、C组(唑来膦酸)各28例;A组氩氦刀冷冻消融治疗结束后给予唑来膦酸注射液4 mg加入0.9%氯化钠注射液100 ml静脉滴注15 min以上;B组单一使用氩氦刀冷冻消融骨转移癌局部组织;C组给予唑来膦酸注射液4 mg加入0.9%氯化钠注射液100 ml静脉滴注15 min以上。结果 ①A组止痛总有效率为85.7%,其中显效为35.7% (10/28),有效为50.0%(14/28);B组止痛总有效率为50.0%,其中显效为14.3%(4/28),有效为35.7%(10/28),C组总有效率为67.9% (19/28),其中显效为21.4%(6/28),有效为46.4%(13/28),3组间比较差异有统计学意义(P < 0.05)。②平均起效时间:A组为(1.96 ± 2.26) d,B组为(1.43 ± 1.79) d,C组为 (11.67 ± 3.14) d, A、B两组与C组之间差异有统计学意义(P < 0.05)。③疗效维持时间:A组为(146.68 ± 1.89) d,B组为(71.60 ± 2.94) d,C组为(112.99 ± 1.37) d,3组间比较差异有统计学意义(P < 0.01)。结论 氩氦刀冷冻消融联合唑来膦酸治疗骨转移癌性疼痛是一种安全、有效的技术。

参考文献/References:


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备注/Memo

备注/Memo:
 (收稿日期:2011-10-27)
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