[1]杨志宏,秦永文,吴 弘,等. 自制新型封堵器堵闭犬左心耳的实验研究[J].介入放射学杂志,2011,(12):989-992.
　YANG Zhi-hong,QIN Yong-wen,WU Hong,et al.A novel device for the occlusion of left atrial appendage: an experimental study in canine models[J].journal interventional radiology,2011,(12):989-992.
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 自制新型封堵器堵闭犬左心耳的实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年12期
页码:
989-992
栏目:
实验研究
出版日期:
2011-12-30

文章信息/Info

Title:
A novel device for the occlusion of left atrial appendage: an experimental study in canine models
作者:
 杨志宏;  秦永文;  吴 弘;  胡建强;  王胜强;  丁仲如;  刘宗军
200433 上海 第二军医大学长海医院心内科
Author(s):
YANG Zhi-hong;  QIN Yong-wen;  WU Hong;  HU Jian-qiang;  WANG Sheng-qiang;  DING Zhong-ru;  LIU Zong-jun.
Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
关键词:
 ; 【关键词】　　　封堵器; 　左心耳; 　动物模型; 　犬
分类号:
R541.7
文献标志码:
A
摘要:
 【摘要】　目的　在实验犬模型上评价新型左心耳封堵器的可操作性、安全性和生物相容性。方法　　　用自行研制的新型左心耳封堵器经导管封堵２０只犬的左心耳，并于术后２周至６个月观察封堵器表面内膜生长情况、有无血栓和移位。采用组织学及扫描电镜观察封堵器表面内膜及内皮生长情况。透射电镜检查内皮及组织细胞有无生长异常。结果　１４只犬即刻成功植入封堵器。术后检查封堵器无移位，表面无血栓，左心耳完全封闭。光镜及扫描电镜检查显示，术后１个月封堵器表面覆盖纤维内膜组织，上有内皮细胞生长，３个月则完全被内皮覆盖。透射电镜检查见内皮细胞、封堵器附近心房肌肌节及线粒体形态、结构正常。肉眼及光镜下见肺、脾、肝、肾无栓塞或梗死表现。结论　新型左心耳封堵装置操作方便、安全可行，长期植入的安全性有待进一步研究。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2011-07-30)
更新日期/Last Update: