[1]陈跃光,张大东,顾俊,等.冠状动脉介入诊疗中非离子型对比剂对肾功能的影响和氯沙坦的保护价值[J].介入放射学杂志,2007,(11):727.
　CHEN Yue-guang,ZHANG Da-dong,GU Jun,et al.Protective effects of losartan in renal dysfunction during coronary angiography and intervention caused by low osmolar non-ionic contrast media[J].journal interventional radiology,2007,(11):727.
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冠状动脉介入诊疗中非离子型对比剂对肾功能的影响和氯沙坦的保护价值()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2007年11期
页码:
727
栏目:
心脏介入
出版日期:
2007-11-15

文章信息/Info

Title:
Protective effects of losartan in renal dysfunction during coronary angiography and intervention caused by low osmolar non-ionic contrast media
作者:
陈跃光; 张大东; 顾俊; 等
２０１１００上海市闵行区中心医院心内科
Author(s):
CHEN Yue-guang; ZHANG Da-dong; GU Jun; SONG Zhi-ping; YU Qiang; FENG Xiao-di; XIAO Hong-bing; YIN Gui-zhi; GUAN Ping; CHEN Cheng-jun; YANG Hui; JIN Xian; DONG Jian; FAN Xiao-min
Department of Cardiology，Shanghai Minhang Central Hospital，Shanghai２０１１００，China
关键词:
经皮冠状动脉介入治疗; 对比剂; 对比剂肾病熏血管紧张素Ⅱ受体拮抗剂
分类号:
R７１４.２２
文献标志码:
A
摘要:
目的评价采用非离子低分子对比剂行冠脉造影和介入治疗对于肾功能的影响，并比较单纯冠脉造影和冠脉介入治疗手术前后肾功能的差异；评价氯沙坦对于冠脉介入治疗前后肾功能（血肌酐）和尿微量白蛋白的影响。方法根据冠状动脉造影的结果将我院收治的１７１例患者分３组，第１组为造影阴性组（CAG熏７３例），第２组为常规介入治疗组（PCI熏５２例），第３组为介入治疗＋氯沙坦组（４６例）；研究对比剂对３组肾脏功能和尿微量白蛋白的影响。在检查前及术后的第１、３、７天分别测试尿微量白蛋白和肾功能（血肌酐），然后比较对比剂碘佛醇应用前后各组的差异。结果各组血肌酐均无明显变化，而PCI组尿微量白蛋白比CAG组的患者高（P＜０．０５）；在氯沙坦干预后，PCI后尿微量白蛋白有明显下降（P＜０．０５）。结论CAG和PCI时，非离子低分子对比剂对肾功能（血肌酐）无明显影响，而尿微量白蛋白在术后有不同程度的升高，在PCI组中更明显；氯沙坦能降低PCI术后的尿微量白蛋白，可能具有预防对比剂肾病的作用。

参考文献/References:

［１］陈跃光，吕宝经．对比剂肾功能损害防治的研究进展［J］．介入放射学杂志，２００６，１５：３８２-３８４．
［２］Bailey SR．Review in cardiovascular medicine［J］．２００１，２（suppl１）：s１４-s１８．
［３］倪均，沈卫峰．非离子型对比剂在肾动脉介入治疗中的安全性研究［J］．介入放射学杂志，２００４，１３：１４２-１４３．
［４］刁军，武维恒，蔡文标．冠状动脉造影检查术造影剂对肾功能的影响［J］．中国心血管病研究杂志，２００４，１３：１３７-１３９．
［５］倪靖炜，张瑞岩，张建盛，等．非离子型双体对比剂在冠状动脉介入治疗中应用的安全性观察［J］．介入放射学杂志，２００６，１５：３２７-３２９．
［６］Taliercio CP，Vlietstra RE，Fisher LD，et al．Risks for renal dysfunction with cardial angiography［J］．Ann Int Med，１９８６，１０４：５０１-５０４．
［７］Rich MW，Crecelius CA．Incidence，risk factors and clinic course of acute renal insufficiency after cardiac catheterization in patients７０years of age or older［J］．Arch Intern Med，１９９０，１５０：１２３７-１２４２．
［８］Weisberg LS，Kurnik PB，Kurnik BRC．Risk of radiocontrast nephropathy in patients with and without diabetes mellitus［J］．Kidney Int，１９９４，４５：２５９-２６５．
［９］Manske CL，Sprafka JM，Strony JT，et al．Contrast nephropathy in azotemic diabetes patients undergoing coronary angiography［J］．Am J Med，１９９０，８９：６１５-６２０．
［１０］Hou SH，Bushinsky DA，Wish JB，et al．Hospital-acquired renal insufficiency：a prospective study［J］．Am J Med，１９８３，７４：２４３-２４８．
［１１］McCullough CL，Wolyn R，Rocher LL，et al．Acute renal failure after coronary intervention：incidence，risk factors and relationship to mortality［J］．Am J Med，１９９７，１０３：３６８-３７５．
［１２］张曦，朱水平，赵从禄，等．氯沙坦对慢性肾功能不全性高血压及蛋白尿的影响［J］．中国新药杂志，２０００，９：８４９-８５０．
［１３］司晓芸，贾汝汉，黄从新，等．氯沙坦对早期慢性肾衰竭患者蛋白尿和肾功能的影响［J］．中国中西医结合杂志，２０００，１：１６１-１６３．
［１４］Scaglione R，Argano C，Corrao S，et，al．Transforming growth factorβ１and additional renoprotective effect of combination ACEI and angiotensinⅡreceptor in hypertension subjects with minor renal abnormalities：a２４-week randomized controlled trial［J］．J Hypertension，２００５，２３：６５７-６６４

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备注/Memo

备注/Memo:
收稿日期：２００７-０４-２５
基金项目：上海市闵行区自然科学研究课题资助项目
更新日期/Last Update: 2007-11-15