[1]王志军,王茂强,李功杰,等.介入微创治疗巨脾-脾亢新技术的实验研究[J].介入放射学杂志,2007,(05):339.
 WANG Zhi-jun,WANG Mao-qiang,LI Gong-jie,et al.Experimental study of a new micro-invasive endovascular technique for treatment of megalosplenia and hypersplenism[J].journal interventional radiology,2007,(05):339.
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介入微创治疗巨脾 - 脾亢新技术的实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2007年05期
页码:
339
栏目:
实验研究
出版日期:
2007-05-15

文章信息/Info

Title:
Experimental study of a new micro-invasive endovascular technique for treatment of megalosplenia and hypersplenism
作者:
王志军王茂强李功杰
100853北京解放军总医院介入医学科(王志军、王茂强、段峰、宋鹏、王仲朴、刘凤永)鸦解放军第三0七医院放射科(李功杰)鸦湖北省宜昌市第二人民医院(汪维阳)
Author(s):
WANG Zhi-junWANG Mao-qiangLI Gong-jieDUAN FengWANG Zhong-puLIU Feng-yongSONG PengWANG Wei-yang.
Department of Interventional Radiology,The General Hospital of PLA,Beijing100853,China
关键词:
实验研究巨脾脾亢动脉治疗性栓塞术介入放射学
分类号:
R551.1
文献标志码:
B
摘要:
目的应用在球囊导管阻断脾动脉主干下作脾动脉分支“铸型式”栓塞术,观察健康长白猪脾脏栓塞后影像学、病理学、血象、生化及免疫功能的变化,评估该方法的安全性及效果。方法对实验组进行了在球囊导管阻断脾动脉主干下经微导管用α-氰基丙烯酸正丁酯(NBCA)作脾动脉铸型栓塞术。对照组,行常规经导管选择性脾动脉栓塞术,栓塞材料为PVA颗粒和明胶海绵碎粒。栓塞后观察两组动物栓塞脾脏影像学、病理学及实验组动物生化、血象、免疫功能的变化。结果①实验动物组,在球囊导管阻断脾动脉主干30min后、脾动脉铸型栓塞术后4周复查脾脏CT平扫显示脾脏体积均较栓塞前明显缩小(P<0.05);血管造影显示,术后脾动脉主干完全闭塞,未见侧支循环建立。②病理检查:与实验组相比,对照组术后组织淤血性、出血性坏死更明显;栓塞4周后脾脏铸型栓塞处明显萎缩。③实验室检查:实验组栓塞前后血常规、生化、免疫球蛋白无明显变化(P>0.05)。结论①在球囊阻断脾动脉主干下,用微型导管和组织胶-碘油乳剂栓塞脾动脉具有血管铸型效果,栓塞后脾脏明显萎缩,栓塞效果确实。②与常规经导管栓塞脾动脉术相比,新栓塞技术术后反应较轻。③铸型栓塞术后可以避免因侧支循环的建立而影响治疗效果。

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备注/Memo

备注/Memo:
收稿日期:2006-08-01
更新日期/Last Update: 2007-05-15