[1]万智勇,张 磊,卢子瑄,等.温敏药物缓释栓塞剂行兔肝动脉栓塞的实验研究[J].介入放射学杂志,2011,(07):559.
　WAN Zhi-yong,ZHANG Lei,LU Zi-xuan,et al.Hepatic artery embolization using thermosensitive and slow-release drug as embolic agents: an experimental study in rabbits[J].journal interventional radiology,2011,(07):559.
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温敏药物缓释栓塞剂行兔肝动脉栓塞的实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年07期
页码:
559
栏目:
实验研究
出版日期:
2011-07-30

文章信息/Info

Title:
Hepatic artery embolization using thermosensitive and slow-release drug as embolic agents: an experimental study in rabbits
作者:
万智勇;  张 磊;  卢子瑄;  张敏洁;  王 彬;  段友容
200125 上海市浦东新区浦南医院肿瘤介入科；上海市肿瘤研究所
Author(s):
WAN Zhi-yong;  ZHANG Lei;  LU Zi-xuan;  ZHANG Ming-jie;  WANG Bin;  DUAN You-rong
Department of Oncology and Interventional Radiology, Punan Hospital, Shanghai Pudong New District, Shanghai 200125, China
关键词:
栓塞剂; 药物缓释; 温度敏感; 　栓塞治疗; 　实验性
分类号:
Ｒ７３３６
文献标志码:
Ｂ
摘要:
目的 探讨温敏药物缓释栓塞剂行肝动脉栓塞治疗的可行性与疗效。方法　　　选用新西兰大白兔１５只，以自组包载“碘海醇”温敏缓释剂泊洛沙姆４０７（Ｐｌｕｒｏｎｉｃ Ｆ１２７）行肝动脉栓塞术，术后随访４周，定期复查肝功能、ＤＳＡ、ＣＴ及动物处死后组织病理检查。结果　　　术后丙氨酸转氨酶（ＡＬＴ）和天冬氨酸转氨酶（ＡＳＴ）一过性增高， ２周后恢复正常。术后即刻行肝动脉ＤＳＡ造影，见栓塞区段以下分支完全性闭塞；４周复查造影显示栓塞小动脉未显示再通；术后１　～　２周ＣＴ复查可见栓塞区出现肝实质液化性梗死灶，４周仍见斑点状坏死灶。栓塞区高密度对比剂ＣＴ值随时间逐渐下降，持续时间达４周，并从中心区向边缘扩散。术后即刻行肝、肺病理检查见栓塞区肝动脉段一下分支被栓塞剂完全充填，肝窦内及门静脉肝静脉内未见栓塞剂，双肺动脉各级分支内未见栓塞剂；术后３　ｄ，１、２、４周见窦前小动脉有条絮状栓塞剂和血栓混合物；肝小叶结构完全消失，周围见纤维结缔组织增生。结论　　　温敏药物缓释栓塞剂在体温下快速形成固态，达到末梢动脉栓塞的效果，同时药物缓释持续时间达４周，是一种较为安全、理想的栓塞剂。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：２０１１０４２８
更新日期/Last Update: 2011-07-30