[1]杨 茂,郭　　　志,司同国,等.动脉化疗栓塞联合CI K细胞过继免疫治疗对中晚期肝癌患者免疫功能的影响[J].介入放射学杂志,2011,(02):116-119.
　YANG Mao,GUO Zhi,SI Tong-guo,et al.Influence of transcatheter arterial chemoembolization combined with cytokine-induced killer cell on the immune function in patients with advanced primary hepatocellular carcinoma[J].journal interventional radiology,2011,(02):116-119.
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动脉化疗栓塞联合CI K细胞过继免疫治疗对中晚期肝癌患者免疫功能的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年02期
页码:
116-119
栏目:
肿瘤介入
出版日期:
2011-03-15

文章信息/Info

Title:
Influence of transcatheter arterial chemoembolization combined with cytokine-induced killer cell on the immune function in patients with advanced primary hepatocellular carcinoma
作者:
杨 茂; 　　　郭　　　志; 　　　司同国; 　　　邢文阁; 　　　刘　　　方; 　　　李保国; 　　　于海鹏
300060  天津医科大学附属天津肿瘤医院肿瘤介入治疗科 天津市肿瘤防治重点实验室
Author(s):
YANG Mao;  GUO Zhi;  SI Tong-guo;  XING Wen-ge;  LIU Fang;  LI Bao-guo;  YU Hai-peng
Department of Interventional Therapy, Cancer Institute and Affiliated Hospital of Tianjin Medical University, Tianjin 300060, China.
关键词:
原发性肝细胞癌; 　细胞因子诱导杀伤细胞; 　Ｔ淋巴细胞亚群; 　ＮＫ细胞; 　ＣＤ４＋ＣＤ２５＋调节Ｔ细胞（Ｔｒｅｇ细胞）
分类号:
Ｒ７３５.７
文献标志码:
A
摘要:
目的 分析肝动脉化疗栓塞（ＴＡＣＥ）联合细胞因子诱导的杀伤细胞（ＣＩＫ）过继免疫治疗对中晚期肝癌患者外周血Ｔ淋巴细胞亚群及ＮＫ细胞的影响及临床意义。方法 回顾天津肿瘤医院１３６例中晚期原发性肝癌患者（均为ＴＡＣＥ术后， 经影像学检查显示无远处转移）资料，依据治疗方式分为两组：ＴＡＣＥ联合ＣＩＫ治疗６７例为研究组，单纯ＴＡＣＥ治疗６９例为对照组。分别于治疗前、治疗后相同时间点取外周血，测定ＡＦＰ、Ｔ淋巴细胞亚群及ＮＫ细胞计数变化；术后１个月采用增强ＣＴ、ＭＲＩ或ＰＥＴＣＴ评价肿瘤坏死程度。结果 研究组与对照组近期疗效及ＡＦＰ下降率比较，差异无统计学意义（Ｐ ＞ ０．０５）。对照组治疗前后比较，ＣＤ３＋、ＣＤ４＋、ＮＫ细胞比率及ＣＤ４＋／ＣＤ８＋分别由（５０．２６ ± ６．３７）％、（５３．２０ ± ９．２９）％、（２１．０３ ± ８．５８）％、１．５８ ± ０．４３下降至（４８．９５ ± ８．８３）％（Ｐ ＞ ０．０５）、（５０．０９ ± ９．９９）％（Ｐ ＜ ０．０１）、（１９．６３ ± ８．４２）％（Ｐ ＞ ０．０５）、１．４４ ± ０．５２（Ｐ ＜ ０．０１），ＣＤ８＋、Ｔｒｅｇ细胞比率分别由（３５．７０ ± ８．７１）％、（６．５５ ± １．４７）％上升至（３８．０４ ± １０．５０）％（Ｐ ＜ ０．０５）、（６．７６　±　１．６７）％（Ｐ ＞ ０．０５）。研究组治疗前后比较，ＣＤ３＋、ＣＤ４＋、ＮＫ细胞比率及ＣＤ４＋／ＣＤ８＋分别由（５０．５１ ± １２．３７）％、（５２．４８ ± １５．５５）％、（２０．６７ ± １０．９２）％、１．７６ ± ０．９０上升至（５３．６２ ± １１．３７）％（Ｐ ＜ ０．０１）、（５５．６２±１４．６３）％（Ｐ ＜ ０．０５）、（２３．２３ ± １０．３７）％（Ｐ ＜ ０．０１）、１．９４ ± ０．８４（Ｐ ＜ ０．０１），ＣＤ８＋、Ｔｒｅｇ细胞比率分别由（３５．６１±１２．９０）％、（６．５７ ± ４．８８）％下降至（３２．６８ ± １０．５６）％（Ｐ ＜ ０．０５）、（４．７７ ± １．９９）％（Ｐ ＜　０．０１）。结论 ＴＡＣＥ术后联合ＣＩＫ细胞过继性免疫治疗可以改善患者免疫状态，提高机体的抗肿瘤免疫效应，有可能降低中晚期ＨＣＣ患者ＴＡＣＥ术后的复发和转移机会。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：２０１００８１３
更新日期/Last Update: 2011-03-15