[1]许永华,符忠祥,杨利霞,等.ＭＲＩ导航和温度监控下高强度聚焦超声治疗子宫肌瘤[J].介入放射学杂志,2010,(11):869-873.
　XU Yong-hua,FU Zhon-gxiang,YANG Li-xia,et al.MR-guided high intensity focused ultrasound thermoablation under temperature mapping monitoring for the treatment of uterine fibroids[J].journal interventional radiology,2010,(11):869-873.
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ＭＲＩ导航和温度监控下高强度聚焦超声治疗子宫肌瘤()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年11期
页码:
869-873
栏目:
非血管介入
出版日期:
2010-11-25

文章信息/Info

Title:
MR-guided high intensity focused ultrasound thermoablation under temperature mapping monitoring for the treatment of uterine fibroids
作者:
许永华; 符忠祥; 杨利霞; 陈文直; 刘映江; 叶方伟; 王智彪
作者单位： 200031 上海市徐汇区中心医院医学影像科；重庆医科大学生物医学工程系
Author(s):
XU Yong-hua;  FU Zhon-gxiang;  YANG Li-xia;  CHEN Wen-zhi;  LIU Ying-jiang;  YE Fang-wei;  WANG Zhi-biao.
Department of Medical Imaging, Central Hospital of Xuhui District, Shanghai 200031, China
关键词:
高强度聚焦超声; 　子宫肌瘤; 　磁共振
分类号:
Ｒ７３７.３３
文献标志码:
A
摘要:
目的评价高强度聚焦超声（ＨＩＦＵ）在ＭＲ导航定位和靶区焦域温度监控下治疗子宫肌瘤的可行性和疗效。方法采用西门子１．５ＴＡｖａｎｔｏＴＩＭＭＲ导航和温度监控ＪＭＨＩＦＵ进行ＨＩＦＵ治疗５２例子宫肌瘤共６１个肌瘤。肌瘤大小（６．１±２．１）ｃｍ，其中浆膜下１０枚、肌壁间４６枚和黏膜下５枚。治疗前、后采用增强扫描ＭＲＩ检查，测量肌瘤体积、消融坏死区域大小占肌瘤体积的比率，并记录治疗时间和超声释放剂量。治疗后３个月ＭＲＩ检查观察肌瘤的缩小情况；同时观察和评估其并发症及不良反应事件发生，并对治疗前后患者症状变化进行评分。结果ＭＲ导航ＨＩＦＵ（ＭＲｇＨＩＦＵ）治疗前和治疗后３个月肌瘤平均体积分别为（１１３．３±８７．７）ｃｍ３和（５８．１±４５．０）ｃｍ３，肌瘤体积平均缩小（４８．７±１６．４）％（Ｐ＜０．０５）；每个肌瘤被消融区域占整个肌瘤体积平均为（７８．８±１８．８）％（５１％～１００％）；聚焦超声治疗时间（１９．８±８．８）ｍｉｎ，治疗所用的超声热剂量为（７．１±６．７）焦耳／ｍｍ３。患者症状平均总分治疗前、后从（２４．７±４．８）下降至（１６．７±３．２）分（Ｐ＜０．０５），除１例术中出现腹壁皮下轻度烫伤，余无并发症及不良反应事件。结论ＭＲｇＨＩＦＵ治疗子宫肌瘤是一种可行、安全、有效的无创治疗方法，而且单次热消融可达到肌瘤大部分甚至完全凝固性坏死，并使其短期内缩小的治疗效果。

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备注/Memo

备注/Memo:
收稿日期：２０１００９０３
更新日期/Last Update: 2010-11-25