[1]郭建海,杨仁杰.血清nm２３－H１水平对肝细胞肝癌TACE治疗预后的影响[J].介入放射学杂志,2010,(06):463.
　GUO Jianhai,Yang Renjie.Impact of serum nm２３－H１level on the prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization treatment[J].journal interventional radiology,2010,(06):463.
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血清nm２３－H１水平对肝细胞肝癌TACE治疗预后的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年06期
页码:
463
栏目:
肿瘤介入
出版日期:
2010-06-15

文章信息/Info

Title:
Impact of serum nm２３－H１level on the prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization treatment
作者:
郭建海; 杨仁杰
１００１４２北京北京大学临床肿瘤学院、北京肿瘤医院暨北京市肿瘤防治研究所介入治疗科，恶性肿瘤发病机制及转化研究教育部重点实验室
Author(s):
GUO Jian－hai; Yang Ren－jie
Key Laboratory of Carcinogenesis and Translational Research（Ministry of Education），Department of Interventional Therapy，School of Oncology，Peking University，Beijing Cancer Hospital＆Institute，Beijing１００１４２，China
关键词:
肝细胞肝癌; TACE; nm２３－H１基因; 预后; 酶联免疫吸附试验
分类号:
R７３５.７
文献标志码:
A
摘要:
目的探讨肝细胞肝癌患者血清nm２３－H１基因水平及其对TACE治疗预后的影响。方法收集６０例行TACE治疗的肝细胞肝癌患者血清，采用ELISA检测血清nm２３－H１水平，并与１２例正常对照组进行比较。回顾性分析所有患者的临床病理资料，对患者血清nm２３－H１水平与临床资料进行相关性分析，用Kaplan－Meier生存曲线分析患者生存率，并用log等级检验比较。多因素分析方法评估血清nm２３－H１水平及相关因素对预后的意义。结果肝细胞肝癌患者血清nm２３－H１平均水平为（１２６．４±５１．３）ng ／ml ，明显低于正常对照组的（２２８．３±３８．９）ng ／ml （P＜０．０１）。患者血清nm２３－H１水平与白蛋白水平呈负相关（r＝－０．２５６，P＝０．０４８），而与患者年龄及血清AFP、ALT、AST、GGT、胆红素水平均无相关性。随访１周～８３个月，中位随访时间为１７．５个月。单因素分析显示肝外转移、门静脉瘤栓、动静脉瘘和血清AFP升高是预后不良的因素。多因素COX模型分析显示血清nm２３－H１水平是影响生存的因素之一。结论血清nm２３－H１水平有可能作为肝细胞肝癌患者TACE治疗疗效观察及预后判断的有用指标。

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备注/Memo

备注/Memo:
收稿日期：２０１０－０１－２６
基金项目：国家传染病防治科技重大专项资助（项目编号：２００８ZX１０００２－２６）
更新日期/Last Update: 2010-06-15