[1]姚志敏,佟小强,宋莉,等.宫颈癌术前动脉化疗栓塞疗效[J].介入放射学杂志,2009,(03):189.
 YAO Zhimin,TONG Xiaoqiang,SONG Li,et al.Preoperative transarterial chemoembolization for cervical cancer:analysis of efficacy[J].journal interventional radiology,2009,(03):189.
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宫颈癌术前动脉化疗栓塞疗效()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年03期
页码:
189
栏目:
肿瘤介入
出版日期:
2009-03-15

文章信息/Info

Title:
Preoperative transarterial chemoembolization for cervical cancer:analysis of efficacy
作者:
姚志敏佟小强宋莉
100034北京大学第一医院介入血管外科
Author(s):
YAO Zhi-minTONG Xiao-qiangSONG Li ZOU Ying-hua
Department of Interventional Radiology&Vascular Surgery,the First Affiliated Hospital,Beijing University,Beijing100034,China
关键词:
宫颈癌经动脉化疗栓塞病理新辅助化疗
分类号:
R737.33
文献标志码:
A
摘要:
目的研究局部进展期宫颈癌术前子宫动脉化疗栓塞的疗效及病理改变。方法经阴道镜活检证实宫颈癌患者43例,其中鳞癌38例,腺癌5例;FIGO临床分期ⅠB2期14例,ⅡA期5例,ⅡB期23例,ⅢB期1例。所有患者均进行1次子宫动脉化疗栓塞,化疗药物为博莱霉素+顺铂+异环磷酰胺,栓塞剂为明胶海绵颗粒。其后择期行子宫广泛切除加盆腔淋巴结清扫术,分析手术及病理所见。结果①介入治疗后CR4例,PR29例,总有效率为76.7%。②介入治疗与外科手术间隔时间为肿瘤治疗无效的风险因素,即随着间隔时间延长介入疗效下降。③术后病理显示,镜下表现为肿瘤细胞退行性变,凋亡,肿瘤组织结构松散,周边及肿瘤内大量炎细胞浸润,纤维组织增生,部分病例镜下未见肿瘤细胞。宫旁浸润率减低,部分肿瘤分期逆转,术后病理与术前病理比较10例分化程度降低,5例术后未见肿瘤或残余个别肿瘤细胞而不能判定分化,9例分化程度增高,19例无变化。结论子宫动脉化疗栓塞用于宫颈癌根治新辅助化疗安全有效,可在短期内有效控制肿瘤生长,并可能降低临床分期,有利于肿瘤根治切除。介入治疗后应尽早择期进行手术而不宜过于延长间隔时间。

参考文献/References:

[1]蔡丽萍,龚沂.宫颈癌新辅助化疗中动脉介入化疗现状[J].肿瘤学杂志,2007,13:117-118.
[2]Janicek MF ,Averette HE.Cervical cancer:prevention,diagnosis,and therapeutics[J].CA Cancer J Clin,2001,51:92-114.
[3]Waggoner SE.Cervical cancer[J].Lancet,2003,361:2217-2225.
[4]Supraser

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备注/Memo

备注/Memo:
收稿日期:2008-12-25
更新日期/Last Update: 2009-03-15