[1]袁正,叶晓丹,董生,等.３１ P－MR波谱分析技术评价化疗栓塞治疗肝细胞癌疗效的初步研究[J].介入放射学杂志,2008,(11):779-783.
　YUAN Zheng,YE Xiaodan,DONG Sheng,et al.Value of ３１ P MR spectroscopy in monitoring the early response of hepatocellular carcinoma to transcatheter arterial chemoembolization[J].journal interventional radiology,2008,(11):779-783.
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３１ P－MR波谱分析技术评价化疗栓塞治疗肝细胞癌疗效的初步研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2008年11期
页码:
779-783
栏目:
肿瘤介入
出版日期:
2008-11-15

文章信息/Info

Title:
Value of ３１ P MR spectroscopy in monitoring the early response of hepatocellular carcinoma to transcatheter arterial chemoembolization
作者:
袁正; 叶晓丹; 董生; 等
作者单位：200003上海第二军医大学长征医院影像科
Author(s):
YUAN Zheng; YE Xiao－dan; DONG Sheng; XU Li－chao; SUN Zhi－chao; XIAO Xiang－sheng．
Department of Radiology，Changzheng Hospital，Second Military Medical University，Shanghai２００００３，China
关键词:
肝细胞肝癌; 磁共振成像; 磷谱; 化疗栓塞; 随访
分类号:
R７３５.７
文献标志码:
A
摘要:
目的评价MR磷谱分析（ ３１ P－MRS）早期监测肝细胞癌（HCC）化疗栓塞治疗疗效的价值。方法对１５例因HCC接受化疗栓塞治疗的患者（共１７个癌灶）分别在治疗前和治疗后４８h内进行 ３１ P－MRS检查，５名健康志愿者也接受相同参数的检查以作为对照。比较肝癌组织和正常肝组织中的磷酸单酯（PME）和磷酸二酯（PDE）水平；分别计算化疗栓塞前后PME、PDE、与三磷酸核苷比值（PME／NPT）、PDE／NPT，并对治疗前、后数据进行统计学处理。与临床随访资料比较，考量各指标在早期评价疗效中的价值。结果HCC治疗后PME水平（中位数：１．３８×１０ ７ ；范围：０．６６５×１０ ７ ～６．２１×１０ ７ ）低于治疗前（中位数：２．９８×１０ ７ ；范围：０．８４６×１０ ７ ～１０２．５×１０ ７ ）（P＜０．０５）。临床随访发现治疗有效病灶 ３１ P－MRS中，治疗后４８h内与治疗前相比PME／NPT（P＜０．０１）和PME／PDE／NPT（P＜０．０１）比值均下降；临床随访中治疗无效的病灶，PME／NPT比值下降（P＜０．０５），而PDE／NPT比值轻度上升，但差异无统计学意义（P＜０．０５）。结论在肝细胞肝癌化疗栓塞治疗前和治疗后４８h内，３１ P－MRS中PME／NPT和PDE／NPT的比值变化对早期评价疗效和指导后续治疗有指导意义。

参考文献/References:

［１］Colombo M．Nonpercutaneous therapies of hepatocellular carcino－ma ［J］．Hepatogastroenterology，２００１，４８：２５－２８．
［２］Ramsey DE，Kernagis LY，Soulen MC，et al．Chemoemboliza－tion of hepatocellular carcinoma ［J］．J Vasc Interv Radiol，２００２，l１３：S２１１－S２２１．
［３］Chen CY，Li CW，Kuo YT，et al．Early response of hepato－cellular carcinoma to transcatheter arterial chemoembolization：choline levels and MR diffusion constants－－initial experience［J］．Radiology，２００６，２３９：４４８－４５６．
［４］Kamel IR，Bluemke DA，Ramsey D，et al．Role of diffusion－weighted imaging in estimating tumor necrosis after chemoem－bolization of hepatocellular carcinoma ［J］．AJR，２００３，１８：７０８－７１０．
［５］Griffiths JR，Tate AR，Howe FA，et al．Magnetic resonance spectroscopy of cancer－practicalities of multi－centre trials and early results in non－Hodgkin’s lymphoma ［J］．Eur J Cancer，２００２，３８：２０８５－２０９３．
［６］Van den Bosch H．Phosphoglyceride metabolism［J］．Ann Rev Biochem，１９７４，４３：２４３－２７７．
［７］Murata O，Sakurai H，Mitsuhashi N，et al． ３１ P NMR spectr os－copy can predict the optimum interval between fractionated irradiation doses［J］．Anticancer Res，１９９８，１８：４２９７－４３０１．
［８］Sakurai H，Mitsuhashi N，Murata O，et al．Early radiation ef－fe cts in highly apoptotic murine lymphoma xenografts monitoredby ３１ P magnetic resonance spectroscopy［J］．Int J Radiat Oncol Biol Phys，１９９８，４１：１１５７－１１６２．
［９］Sijens PE，Baldwin NJ ，Ng TC． ３１ P magnetic resonance spec－troscopy detection of response－predictive adenosine triphosphate decrease in irradiated radiation－induced fibrosarcoma－１tumors［J］．Invest Radiol，１９９７，３２：３９－４３．
［１０］Schilling A，Gewiese B，Berger G，et al．Liver tumors：follow－up with P－３１MR spectroscopy after local chemotherapy and chemoembolization［J］．Radiology，１９９２，１８２：８８７－８９０．
［１１］Meyerhoff DJ ，Karczmar GS，Valone F，et al．Hepatic cancers and their response to chemoembolization therapy．Quantitative image－guided ３１ P－magnetic resonance spectroscopy［J］．Invest Radiol，１９９２，２７：４５６－４６４．
［１２］Cox IJ，Menon DK，Sargentoni J，et al．Phosphorus－３１magnetic resonance spectroscopy of the human liver using chemical shift imaging techniques［J］．J Hepatol，１９９２，１４：２６５－２７５．
［１３］中国抗癌协会肝癌专业委员会．原发性肝癌诊断标准［J］．中华肝脏病杂志，２０００，８：１３５．
［１４］Salem R，Lewandowski RJ ，Atassi B，et al．Treatment of unre－sectable hepatocellular carcinoma with use of９０Y microspheres（TheraSphere）：safety，tumor response，and survival［J］．J Vasc Interv Radiol，２００５，１６：１６２７－１６３９．
［１５］Majors AW，Ng TC，Karalis IM，et al．Phosphorus metabolites and the distribution of cell cycle phase of RIF－１tumors in response to１４Gy irradiation［J］．Magn Reson Med，１９９０，１６：４２５－４３０．
［１６］Sijens PE，Bovee WM，Seijkens D，et al．In vivo ３１ P－nuclear magnetic resonance study of the response of a murine mammary tumor to different doses of gamma－radiation［J］．Cancer Res，１９８６，４６：１４２７－１４３２．
［１７］Street JC，Koutcher JA．Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids［J］．Lipids，１９９７，３２：４５－４９．
［１８］Ng TC，Grundfest S，Vijayakumar S，et al．Therapeutic response of breast carcinoma monitored by ３１ P－MRS in situ［J］．Magn Reson Med，１９８９，１０：１２５－１３４．
［１９］Jackel MC，Kopf－Maier P，Baumgart F，et al．Value of ３１ P－NMR spectroscopy in predicting the response of a xenografted human hypopharynx carcinoma to irradiation［J］．J Cancer Res Clin Oncol，２０００，１２６：３２５－３３１．
［２０］Solga SF，Horska A，Clark JM，et al．Hepatic ３１ P－magnetic resonance spectroscopy：a hepatologist’s user guide［J］．Liver Int ，２００５，２５：４９０－５００．
［２１］Buchli R，Meier D，Martin E，et al．Assessment of absolute metabolite concentrations in human tissue by ３１ P－MRS in vivo．PartⅡ：Muscle，liver，kidney［J］．Magn Reson Med，１９９４，３２：４５３－４５８．
［２２］Wolf RF，Haagsma EB，Kamman RL，et al．Noninvasive me－tabolic assessment of human donor livers：prognostic value of３１P－magnetic resonance spectroscopy for early graft function［J］．Transplantation，１９９７，６４：１４７－１５２．

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备注/Memo

备注/Memo:
收稿日期：２００８－０７－３０
更新日期/Last Update: 2008-11-15