[1]官泳松,贺庆.肝癌介入治疗中应用p５３的几个要点[J].介入放射学杂志,2008,(11):761.
　GUAN Yongsong,HE Qing.Essentials in clinical application of p５３for tumors intervention－example of liver cancer[J].journal interventional radiology,2008,(11):761.
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肝癌介入治疗中应用p５３的几个要点()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2008年11期
页码:
761
栏目:
述评
出版日期:
2008-11-15

文章信息/Info

Title:
Essentials in clinical application of p５３for tumors intervention－example of liver cancer
作者:
官泳松; 贺庆
６１００４１四川大学华西医院四川大学生物治疗国家重点实验室
Author(s):
GUAN Yong－song; HE Qing．
State Key Laboratory of Biotherapy，West China Hospital，West China Medical School，Sichuan University，Chengdu６１００４１，China
关键词:
重组人p５３腺病毒注射液; 经导管动脉化疗栓塞; 肝癌; 协同作用
分类号:
R７３５.７
文献标志码:
C
摘要:
重组人p５３腺病毒注射液（recombinant human adenovirus p５３，Ad－p５３）已被用于与多种局部治疗方法联合治疗肿瘤。本文介绍在肝癌介入治疗过程中联合应用Ad－p５３，应该重点研究两者的机制，最大限度地发挥它们抗肿瘤的协同作用。提出瘤内注射是首选的基因给药途径，建议单个肿瘤注射Ad－p５３的最低用量，以及注射Ad－p５３后进行肝癌介入治疗的最佳时机。介绍以p５３为靶点的治疗方法有好几种理论基础，有些方法甚至相互对立，因此在治疗前须先明确要对p５３进行激活还是抑制。最后提出应用Ad－p５３治疗晚期恶性肿瘤应慎重选择病例。

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备注/Memo

备注/Memo:
收稿日期：２００８－０４－０２
更新日期/Last Update: 2008-11-15