[1]赵 纯,向述天,苏 伟,等.支气管镜导引下圈套器电灼损伤在犬气管狭窄模型中的应用[J].介入放射学杂志,2020,29(11):1116-1119.
 ZHAO Chun,XIANG Shuntian,SU Wei,et al.Application of bronchoscope-guided snare electrocautery injury of airway in establishing canine tracheal stenosis model[J].journal interventional radiology,2020,29(11):1116-1119.
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支气管镜导引下圈套器电灼损伤在犬气管狭窄模型中的应用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年11
页码:
1116-1119
栏目:
实验研究
出版日期:
2020-11-25

文章信息/Info

Title:
Application of bronchoscope-guided snare electrocautery injury of airway in establishing canine tracheal stenosis model
作者:
赵 纯 向述天 苏 伟 曾俊仁 徐 松 赵娟娟 毛崇文 代洪妍
Author(s):
ZHAO Chun XIANG Shuntian SU Wei ZENG Junren XU Song ZHAO Juanjuan MAO Chongwen DAI Hongyan.
Department of Radiology, Forth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650021, China
关键词:
【关键词】 气管狭窄 动物模型 电灼 圈套器
文献标志码:
A
摘要:
【摘要】 目的 探讨纤维支气管镜导引下圈套器电灼犬气管建立气管狭窄模型的可行性、安全性和有效性。 方法 支气管镜导引下用电圈套器灼伤10只健康比格犬气管中段。术后观察犬气促、喘息等情况,每周行支气管镜、CT检查,计算狭窄程度。术后2、4周各处死1只犬,取气管组织行苏木精-伊红(HE)和Masson染色,观察组织炎症和纤维化程度。 结果 所有犬气管电灼伤术均获成功。术后14 d、19 d,所有犬均出现喘息和肋间隙凹陷。术后7 d、14 d、21 d、28 d气管狭窄程度中位数分别为26%、72%、86%、90%。组织病理学观察显示,术后14 d气管黏膜见重度炎症浸润,伴少量纤维组织生长;术后25 d炎症浸润以淋巴细胞为主,见多量纤维化。 结论 支气管镜导引下圈套器电灼法建立犬气管狭窄模型,具有操作简便、快速,安全,可重复性强,临床相似度高等优点。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2019- 12- 23)
(本文编辑:边 佶)
更新日期/Last Update: 2020-11-16