[1]游建雄,王精兵,赵 庆,等.超选择膀胱动脉化疗栓塞治疗晚期膀胱癌伴出血的疗效分析 [J].介入放射学杂志,2019,28(07):647-651.
YOU Jianxiong,WANG Jingbing,ZHAO Qing,et al.Efficacy of superselective bladder arterial chemoembolization for the treatment of advanced bladder cancer with bleeding[J].journal interventional radiology,2019,28(07):647-651.
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超选择膀胱动脉化疗栓塞治疗晚期膀胱癌伴出血的疗效分析
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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28
- 期数:
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2019年07期
- 页码:
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647-651
- 栏目:
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肿瘤介入
- 出版日期:
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2019-07-25
文章信息/Info
- Title:
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Efficacy of superselective bladder arterial chemoembolization for the treatment of advanced bladder cancer with bleeding
- 作者:
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游建雄; 王精兵; 赵 庆; 郑连洲; 范新东; 苏立新; 温明哲; 杨西涛
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- Author(s):
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YOU Jianxiong; WANG Jingbing; ZHAO Qing; ZHENG Lianzhou; FAN Xindong; SU Lixin; WEN Minzhe; YANG Xitao.
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Department of Interventional Therapy, Affiliated Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201999, China
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- 关键词:
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【关键词】 超选择性膀胱动脉栓塞; 晚期膀胱癌; 顽固性血尿; 碘化油乳剂
- 文献标志码:
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A
- 摘要:
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【摘要】 目的 探讨经导管膀胱动脉化疗栓塞治疗晚期膀胱癌伴出血的临床疗效及安全性。方法 2005年6月至2018年3月共收治32例晚期膀胱癌伴出血患者,其中移行细胞癌(TCC)30例,鳞状细胞癌(SSC)2例。所有患者均行超选择膀胱动脉插管,先行顺铂+吡柔比星灌注化疗,再以碘化油-吡柔比星乳剂以及明胶海绵颗粒栓塞肿瘤血管,疗程间隔时间1~3个月。结果 32例患者共行98次栓塞治疗(平均每例3.1次),其中29例(90.6%)首次术后48 h内完全止血,另外3例再次介入治疗后完全止血。平均随访20.2(6~72)个月,半年生存率为93.8%(30/32);22例(68.8%)患者血尿未复发。10例患者随访期间血尿复发,其中8例再次栓塞,另外2例保守治疗; 16例患者(50.0%)在TACE之前需要输血平均3.5(1~8)单位,TACE后仅3例(9.4%)需再次输血。术后2周血红蛋白水平由术前的(85.2±16.9) g/L明显增高至(102.1±17.4) g/L(P<0.001)。随访期间无与介入相关的严重并发症,轻度不良反应如发热、恶心和尿路刺激征,均在3~7 d后消失。本组患者末次治疗后1个月CT或MRI影像资料显示,病灶完全缓解(CR)9例,部分缓解(PR)18例,稳定(NC)3例,疾病进展(PD)2例,总有效率(CR+PR)为84.4%,疾病获益率(CR+PR+NC)为93.8%。结论 对于晚期膀胱癌伴出血患者,采用碘油-化疗药乳剂超选择性栓塞膀胱动脉是一种安全有效的方法。
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备注/Memo
- 备注/Memo:
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(收稿日期:2018-11-07)
(本文编辑:俞瑞纲)
更新日期/Last Update:
2019-07-16