[1]朱武刚,陆晓兰,刘洪涛,等.肝癌根治术后辅助TACE疗效的meta分析 [J].介入放射学杂志,2019,28(09):865-869.
 ZHU Wugang,LU Xiaolan,LIU Hongtao,et al.Radical resection of liver cancer with subsequent adjuvant transcatheter arterial chemoembolization: meta analysis of curative effect[J].journal interventional radiology,2019,28(09):865-869.
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肝癌根治术后辅助TACE疗效的meta分析
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
28
期数:
2019年09期
页码:
865-869
栏目:
临床研究
出版日期:
2019-09-25

文章信息/Info

Title:
Radical resection of liver cancer with subsequent adjuvant transcatheter arterial chemoembolization: meta analysis of curative effect
作者:
朱武刚 陆晓兰 刘洪涛 徐 浩 顾玉明
Author(s):
ZHU Wugang LU Xiaolan LIU Hongtao XU Hao GU Yuming.
Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province 221000, China
关键词:
【关键词】 原发性肝细胞肝癌 肝切除 化疗栓塞 疗效 荟萃分析
文献标志码:
A
摘要:
【摘要】 目的 系统评价肝细胞癌(HCC)根治性切除术后行辅助性TACE的疗效。方法 计算机检索PubMed、EMBASE、Cochrane Library、CBM、CNKI、万方数据库和维普中文科技期刊数据库中所有相关的随机对照试验,截止日期为2017年11月20日。依据Cochrane手册进行质量评估。纳入文献采用RevMan5.3软件进行统计分析。结果 本次meta分析纳入8篇随机对照研究文献,其中单纯手术治疗患者390例,手术联合辅助TACE患者389例,共计779例患者。分析结果显示辅助TACE组可有效降低HCC患者术后1年复发率(RR=0.49,95%CI:0.35~0.68,P<0.000 1)和2年复发率(RR=0.61,95%CI:0.44~ 0.85,P=0.003);与术后行辅助TACE组相比单纯手术可提高患者术后1、3年总生存率(RR=1.38,95%CI:1.21~ 1.57,P<0.000 01;RR=1.94,95%CI:1.40~2.70,P<0.000 1))并显著改善术后1、3年无病生存率(RR=1.49,95%CI:1.10~ 2.03,P=0.010;RR=3.02,95%CI:1.24~7.34,P=0.01)。术后1年复发率、1年生存率Egger检验P值分别为0.659和0.295,均提示无发表偏倚。结论 术后辅助TACE可有效降低患者术后早期复发率、提高总生存率和无病生存率,但长期疗效及治疗适应症的选择尚需进一步高质量的临床研究。

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相似文献/References:

[1]刘光华,夏 芳,欧阳强.肝动脉化疗栓塞对肝细胞癌切除术后预防复发的研究[J].介入放射学杂志,2015,(02):125.
 LIU Guang hua,XIA Fang,OUYANG Qiang..The effect of transcatheter arterial chemoembolization on the prevention of recurrence in hepatocellular carcinoma following hepatectomy[J].journal interventional radiology,2015,(09):125.

备注/Memo

备注/Memo:
(收稿日期:2018-10-17)

(本文编辑:俞瑞刚)
更新日期/Last Update: 2019-09-24