[1]魏晓晴,吴 杰,宋 磊,等.结直肠癌术后区域性动脉灌注化疗与静脉化疗对比研究 [J].介入放射学杂志,2019,28(01):32-37.
WEI Xiaoqing,WU Jie,SONG Lei,et al.Regional arterial infusion chemotherapy vs intravenous chemotherapy in treating colorectal cancer after radical resection[J].journal interventional radiology,2019,28(01):32-37.
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结直肠癌术后区域性动脉灌注化疗与静脉化疗对比研究
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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28
- 期数:
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2019年01期
- 页码:
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32-37
- 栏目:
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肿瘤介入
- 出版日期:
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2019-01-25
文章信息/Info
- Title:
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Regional arterial infusion chemotherapy vs intravenous chemotherapy in treating colorectal cancer after radical resection
- 作者:
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魏晓晴; 吴 杰; 宋 磊; 白建新; 杨笑宏; 高 飞; 高金琦
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- Author(s):
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WEI Xiaoqing; WU Jie; SONG Lei; BAI Jianxin; YANG Xiaohong; GAO Fei; GAO Jinqi
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Department of Interventional Radiology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116000, China
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- 关键词:
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【关键词】 结直肠癌术后; 局部灌注化疗; 局部复发; 远处转移
- 文献标志码:
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A
- 摘要:
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【摘要】 目的 评价肝动脉联合区域动脉灌注化疗对减少结直肠癌根治术后转移复发、提高远期疗效的作用。方法 回顾性分析2008年3月—2012年10月接受结直肠癌根治性手术的Ⅱ期和Ⅲ期患者,选择术后肝动脉联合区域动脉灌注化疗(观察组,n=42)和单纯静脉化疗(对照组,n=44)。两组患者在性别、年龄、肿瘤位置、TNM 分期、肿瘤组织学分级、术式选择上差异无统计学意义(P>0.05)。对两组患者定期复查及随访,观察两组患者肝转移和局部复发率、总生存期和无病生存期。截至 2017年10月,所有患者均接受了随访,平均随访时间67.9个月。结果 观察组和对照组3年内肝转移率7.1%对22.7%(χ2=4.067,P<0.05)、局部复发率分别为4.8%对20.5%(χ2=4.744,P<0.05),两组差异均有统计学意义。观察组和对照组患者5年总生存率分别为81.8%对61.4%(χ2=4.197,P<0.05)。观察组恶心、呕吐、白细胞减少等不良反应发生率均低于对照组,但差异无统计学意义(P>0.05)。结论 Ⅲ期结直肠癌根治术后早期预防性地进行肝动脉联合区域动脉灌注化疗能有效降低局部复发率和肝转移的发生率,提高患者5年生存率。
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备注/Memo
- 备注/Memo:
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(收稿日期:2018-03-15)
(本文编辑:俞瑞纲)
更新日期/Last Update:
2019-01-21