[1]邹伟婕,陈 立,黄学卿,等.天冬氨酸转氨酶与中性粒细胞比值对肝癌患者TACE治疗预后的影响[J].介入放射学杂志,2017,(08):705-711.
 ZOU Weijie,CHEN Li,HUANG Xueqing,et al.The prognostic significance of aspartate aminotransferase to neutrophils ratio in HCC patients treated with TACE[J].journal interventional radiology,2017,(08):705-711.
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天冬氨酸转氨酶与中性粒细胞比值对肝癌患者TACE治疗预后的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年08期
页码:
705-711
栏目:
肿瘤介入
出版日期:
2017-08-25

文章信息/Info

Title:
The prognostic significance of aspartate aminotransferase to neutrophils ratio in HCC patients treated with TACE
作者:
邹伟婕 陈 立 黄学卿 王黎洲 蒋天鹏 宋 杰 周 石
Author(s):
ZOU Weijie CHEN Li HUANG Xueqing WANG Lizhou JIANG Tianpeng SONG Jie ZHOU Shi.
Department of Interventional Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province 550004, China
文献标志码:
A
摘要:
【摘要】 目的 探讨经导管肝动脉化疗栓塞(TACE)术前血清天冬氨酸转氨酶(AST)和中性粒细胞比值(ANRI)对肝细胞肝癌患者预后的评估价值。方法 收集2008年1月至2011年6月期间107例肝细胞肝癌患者的临床资料,研究对象均成功施行TACE,以5年总生存率绘制ROC曲线确定截断值,对术前患者的ANRI、AST与淋巴细胞比值(ALRI)、AST与血小板计数比值(APRI)、中性粒细胞与淋巴细胞比值(NLR)、血小板计数与淋巴细胞比值(PLR)及其他临床病理参数进行单因素、多因素Logisitc回归分析及Kaplan- Meier生存分析,以确定上述因素对无病生存期(DFS)和生存期(OS)的预测价值。结果 ANRI与HBsAg、AST、 肝硬化的存在、肿瘤大小、门静脉癌栓及肿瘤的复发具有相关性(P<0.05)。通过单因素分析显示,ANRI、ALRI、APRI、NLR、PLR与接受TACE治疗肝癌患者的DFS和OS具有显著相关性(P<0.05)。多因素Logisitc回归分析显示,ANRI被证明是该类患者DFS和OS的独立影响因素(P<0.05)。Kaplan- Meier生存分析表明,术前ANRI>7.8的患者行TACE治疗后预后较差。结论 TACE术前ANRI水平是肝细胞肝癌患者预后独立的预测因素,ANRI水平较高往往提示该类患者行TACE治疗的预后较差。
【关键词】 天冬氨酸转氨酶; 中性粒细胞; 比值; 肝癌; 动脉化疗栓塞; 预后

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备注/Memo

备注/Memo:
(收稿日期:2016-09-27)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2017-08-11