[1]高力明,许旭东,汤佳旎,等.纳米膜单铆型室间隔缺损封堵器动物实验研究[J].介入放射学杂志,2015,(06):509-514.
 GAO Li- ming,Xu Xu- dong TANG Jia- ni,TAN Hong- wei,et al.Nano material occluder of single rivet type used for percutaneous closure of ventricular septal defect: an experimental study in dogs[J].journal interventional radiology,2015,(06):509-514.
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纳米膜单铆型室间隔缺损封堵器动物实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年06期
页码:
509-514
栏目:
实验研究
出版日期:
2015-06-25

文章信息/Info

Title:
Nano material occluder of single rivet type used for percutaneous closure of ventricular septal defect: an experimental study in dogs
作者:
高力明 许旭东 汤佳旎 谭红伟 耿 亮 刘学波
Author(s):
GAO Li- ming Xu Xu- dong TANG Jia- ni TAN Hong- wei GENG Liang LIU Xue- bo
Department of Cardiology, Affiliated Oriental Hospital, School of Medicine, Tongji University, Shanghai 200120, China
关键词:
【关键词】 纳米材料 室间隔穿刺 室间隔缺损 内皮化 封堵器
文献标志码:
A
摘要:
【摘要】 目的 在室间隔缺损(VSD)犬模型中评价新型纳米膜单铆型VSD封堵器经导管植入的可行性、安全性和有效性,为临床应用提供实验依据。方法 取健康成年犬26只,在开胸X线导引下通过右心室游离壁穿刺室间隔方法制备VSD模型;分为实验组(n=13,植入纳米膜单铆型VSD封堵器)和对照组(n=13,植入镍钛合金双铆型VSD封堵器)。术后1、2、3、6个月分别通过心脏大体标本、光镜、电镜检测及血镍离子浓度测定等评价新型封堵器植入后内皮化过程,观察有无残余分流、血栓形成等并发症。 结果 对26只犬成功建立开胸小切口VSD模型。实验组纳米膜单铆型VSD封堵器植入成功率为100%,对照组镍钛合金双铆型VSD封堵器植入成功率为91.7%。术后1、2、3、6个月分别取出25只犬心脏大体标本,观察显示两组封堵器位置均无移位,无合金丝断裂,盘面未见血栓形成和赘生物附着。术后1个月实验组封堵器双侧盘面可见薄层透亮组织覆盖,病理和电镜检查证实为纤维组织和内皮细胞;至术后6个月,盘面组织逐渐增厚,封堵器边缘与周围心脏组织融合。结论 纳米膜单铆型VSD封堵器设计科学,与镍钛合金双铆型VSD封堵器相比并发症少,完全内皮化时间缩短,可有效封堵VSD,具有良好的临床应用前景。

参考文献/References:

[1] 秦永文, 赵仙先, 李卫萍. 应用自制封堵器经导管闭合膜部室间隔缺损[J]. 介入放射学杂志, 2002, 11: 130- 131.
[2] 秦永文, 赵仙先, 吴 弘, 等. 自制非对称型室间隔缺损封堵器的初步临床应用[J]. 介入放射学杂志, 2004, 13: 101- 103.
[3] 秦永文, 赵仙先, 徐荣良, 等. 应用自制封堵器经导管闭合膜部室间隔缺损[J]. 中华心血管病杂志, 2003, 31: 28.
[4] Gu MB, Bai Y, Zhao XX, et al. Transcatheter closure of postoperative residual perimembranous ventricular septal defects[J]. Ann Thorac Surg, 2009, 88: 1551- 1555.
[5] Anselmino M, Ribezzo M, Orzan F. Nickel allergy, how deep?[J]. Acta Cardiol, 2009, 64: 104- 106.
[6] Retzer EM, Dill KE, Shah AP, et al. Novel transcatheter closure of an iatrogenic perimembranous ventricular septal defect[J].Catheter Cardiovasc Interv, 2015, 85: 161- 165.
[7] Chen F, Zhao X, Zheng X, et al. Incomplete endothelialization and late dislocation after implantation of an Amplatzer septal occluder device[J]. Circulation, 2011, 124: e188- e189.
[8] Armitage DA, Parker TL, Grant DM. Biocompatibility and hemo- compatibility of surface- modified NiTi alloys[J]. J Biomed Mater Res A, 2003, 66A: 129- 137.
[9] Foth R, Quentin T, Michel- Behnke I, et al. Immunohistochemical characterization of neotissues and tissue reactions to septal Defect- Occlusion devices[J]. Circ Cardiovasc Interv, 2009, 2: 90- 96.
[10] Ding ZR, Qin YW, Hu JQ, et al. A new pan- nitinol occluder for transcatheter closure of ventricular septal defects in a canine model[J]. J Interv Cardiol, 2009, 22: 191- 198.
[11] Sigler M, Jux C. Biocompatibility of septal defect closure devices[J]. Heart, 2007, 93: 444- 449.
[12] Ahn E, Luk A, Mezody M. Early morphological changes of an Amplatzer Septal Occluder explanted at heart transplant[J]. Cardiovasc Pathol, 2009, 18: 57- 60.
[13] 高力明, 宗书峰, 游晓华, 等. 左盘无铆型卵圆孔未闭封堵器的实验研究[J]. 介入放射学杂志, 2012, 21: 833- 838.
[14] Ries MW, Kampmann C, Rupprecht HJ. Nickel release after implantation of the Amplatzer occluder[J]. Am Heart J, 2003, 145: 737- 741.
[15] Burian M, Neumann T, Weber M, et al. Nickel release, a possible indicator for the duration of antiplatelet treatment, from a nickel cardiac device in vivo: a study in patients with atrial septal defects implanted with an Amplatzer occluder[J]. Int J Clin Pharmacol Ther, 2006, 44: 107- 112.

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备注/Memo

备注/Memo:
(收稿日期:2014 -11-24)
(本文编辑:边 佶)
更新日期/Last Update: 2015-06-24