[1]陆小华,朱小庆,张玉宇,等.IL 8基因-251T/A和+781C/T多态性与 南通地区肝癌遗传易感性的关联研究[J].介入放射学杂志,2015,(04):314-319.
　LU Xiao hua,ZHU Xiao qing,ZHANG Yu yu,et al.Correlation study on IL 8 Gene-251T/A， +781C/T polymorphisms and genetic susceptibility to hepatocellular carcinoma in Nantong area population[J].journal interventional radiology,2015,(04):314-319.
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IL 8基因-251T/A和+781C/T多态性与 南通地区肝癌遗传易感性的关联研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年04期
页码:
314-319
栏目:
肿瘤介入
出版日期:
2015-04-25

文章信息/Info

Title:
Correlation study on IL 8 Gene-251T/A， +781C/T polymorphisms and genetic susceptibility to hepatocellular carcinoma in Nantong area population
作者:
陆小华;  朱小庆;  张玉宇;  储玉山;  茅国新
Author(s):
LU Xiao hua;  ZHU Xiao qing;  ZHANG Yu yu;  CHU Yu shan;  MAO Guo xin
Department of Interventional Radiology， Affiliated Hospital of Nantong University， Nantong， Jiangsu Province 226001， China
关键词:
原发性肝细胞癌;  白细胞介素-8;  单核苷酸多态性;  遗传易感性
文献标志码:
A
摘要:
目的 了解南通地区人群白细胞介素8（IL 8）基因启动子区（rs4073）、第1内含子区（rs2227306）位点寡核苷酸多态性（SNP）的分布特点，探讨上述位点各基因型及联合基因型与肝细胞癌（HCC）患病风险的关系，分析各基因型与不同暴露因素在HCC发生中的相互作用。方法 采用病例对照研究方法，利用限制性片段长度多态性聚合酶链反应（RFLP PCR）技术对454例肝癌患者及446名健康对照者IL 8基因-251位点和+781位点进行基因分型。结果 ① -251位点杂合突变基因型AT者罹患HCC的风险增加（OR=1.99，95％CI：1.01～3.85），+781位点突变基因型CT、TT者罹患HCC的风险增加（CT基因型OR=1.78，95％CI：1.03～3.10；TT基因型OR=1.36，95％CI：1.01～2.62）。② 携带-251、+781两位点AT CT、TT CT及AT CC联合基因型的个体罹患HCC的风险增加（AT CT联合基因型OR=2.10，95％CI：1.52～2.90；TT CT联合基因型OR=3.33，95％CI：1.01～10.50；AT CC联合基因型OR=3.67，95％CI：2.28～5.90）。③ -251位点SNP与饮酒、HBV感染、肝癌家族史因素在HCC的发生中存在正交互作用，该位点SNP与年龄、性别、吸烟因素在HCC的发生中存在负交互作用；+781位点SNP与饮酒、肝癌家族史因素在HCC的发生中存在正交互作用，该位点SNP与年龄、性别、吸烟、HBV感染因素在HCC的发生中存在负交互作用。结论 南通地区人群IL 8基因-251、+781位点寡核苷酸多态性与HCC患病风险存在关联，并与不同暴露因素在HCC发生中存在交互作用。

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备注/Memo

备注/Memo:
（收稿日期：２０１4-０9-17）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2015-04-27