[1]李国平,龚高全,王建华,等.不可切除的胰腺癌TAI/TACE治疗后回顾性生存分析[J].介入放射学杂志,2015,(02):118-123.
　LI Guo ping,GONG Gao quan,WANG Jian hua,et al.Retrospective survival analysis of patients with unresectable pancreatic carcinomas after receiving transarterial infusion chemotherapy and transarterial chemoembolization treatment[J].journal interventional radiology,2015,(02):118-123.
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不可切除的胰腺癌TAI/TACE治疗后回顾性生存分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年02期
页码:
118-123
栏目:
肿瘤介入
出版日期:
2015-02-25

文章信息/Info

Title:
Retrospective survival analysis of patients with unresectable pancreatic carcinomas after receiving transarterial infusion chemotherapy and transarterial chemoembolization treatment
作者:
李国平;  龚高全;  王建华;  颜志平;  陈 颐;  程洁敏;  刘凌晓;  王小林
Author(s):
LI Guo ping;  GONG Gao quan;  WANG Jian hua;  YAN Zhi ping;  CHEN Yi;  CHENG Jie min;  LIU Ling xiao;  WANG Xiao lin.
Department of Interventional Therapy， Zhongshan Hospital， Fudan University， Shanghai 200032， China
关键词:
【关键词】 胰腺癌;  介入治疗;  中位生存期;  生存分析
文献标志码:
A
摘要:
【摘要】 目的 通过对不可切除的胰腺癌患者159例经TAI/TACE治疗后的回顾性生存分析，评估影响胰腺癌介入治疗后生存期的因素。方法 收集并分析159例胰腺癌患者的TAI/TACE治疗病史资料，并对影响胰腺癌患者TAI/TACE治疗后生存期的因素和治疗模式进行单因素及COX模型多因素分析。结果 159例患者总随访中位生存期（mST）为10.32个月，总的介入治疗后mST为8.11个月，总1年累积生存率27.0%，2年累积生存率11.0%，3年累积生存率2.0%，5年累积生存率为0.6%。根据临床反应率（CBR）评估判定介入治疗后能缓解症状的介入次数平均值为2.6次。单因素分析显示影响胰腺癌介入治疗后MST的主要因素有：初次介入治疗前CA19 9值，及其术后变化，初次介入前KPS评分，初次介入前症状，介入治疗前肝功能分级，介入治疗前有无手术史，介入治疗次数。而年龄，性别，初次介入前血红蛋白值，肿瘤分期（Ⅱ~Ⅲ期与Ⅳ期），初次介入时CEA的值，初次介入前后CEA的变化，治疗药物（是否含吉西他滨联合奥沙利铂），治疗方案（TAI/TACE），术前是否存在糖尿病，肿瘤部位（是否为胰头部），病理是否为导管腺癌，均显示差异无明显统计学意义。多因素分析显示对介入治疗后生存期有影响的独立因素是：开始介入治疗时肝功能分级，初治时KPS评分，有无原发灶手术切除史。结论 TAI/TACE对于胰腺癌患者在改善患者症状和延长中位生存期方面有一定的治疗作用，介入治疗后生存期与患者的体力状态，存在症状和有无早期手术治疗有关。

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备注/Memo

备注/Memo:
（收稿日期：２０１4-０4-22）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2015-02-16