[1]夏永辉,任 玲,徐 克,等. 镁合金血管支架置入后内膜增生特点[J].介入放射学杂志,2014,(02):132-135.
 XIA Yong? hui,REN Ling,XU Ke,et al. Characteristics of neointima proliferation after AZ31 magnesium stent implantation[J].journal interventional radiology,2014,(02):132-135.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年02期
页码:
132-135
栏目:
实验研究
出版日期:
2014-02-28

文章信息/Info

Title:
 Characteristics of neointima proliferation after AZ31 magnesium stent implantation
作者:
夏永辉 任 玲 徐 克 李卫校 毕永华 谭丽丽 陈姗姗
Author(s):
 XIA Yong?蛳 hui REN Ling XU Ke LI Wei?蛳 xiao BI Yong?蛳 hua TAN Li?蛳 li CHEN Shan?蛳 shan.
 Department of Radiology, the First Affiliated Hospital, China Medical University, Shenyang 110001, China
关键词:
【关键词】 内膜增生 再狭窄 支架 镁合金 
文献标志码:
A
摘要:
 【摘要】 目的 观察和评价AZ31镁合金血管支架置入后的内膜增生情况。方法 将24枚采用激光雕刻制成的AZ31镁合金支架置入12只Beagle犬的双侧髂外动脉内,按支架置入术后时间将动物分为1、3、6个月三组,每组4只。在相应时间点取支架段血管进行HE染色,观察镁合金支架置入后内膜增厚程度、新生内膜成分及形态特点。结果 AZ31镁合金支架置入术后1、3、6个月均产生了较明显的内膜增生,内膜-中膜比值分别为1.17 ± 0.06、1.64 ± 0.09、0.91 ± 0.05,相比1个月和6个月,术后3个月时内膜增生最为明显(P < 0.05),且内膜增厚以支架支撑杆周围为著,新生内膜主要成分为排列紊乱的血管平滑肌细胞及细胞外基质,在置入术后早期可见少量的炎性细胞。结论 虽然AZ31镁合金血管支架具有可降解性,但其置入后仍出现不同程度内膜增生,且以3个月时最为明显。

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备注/Memo

备注/Memo:
 (收稿日期:2013-07-11)
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