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[1]李景雷,王晓白,乔宏宇,等.小肠黏膜下层促进经皮血管腔内支架植入术后内皮化的实验研究[J].介入放射学杂志,2013,(05):403-408.
 LI Jing? lei,WANG Xiao? bai,QIAO Hong? yu,et al. The promotion effect of small intestinal submucous layer on the endothelial regeneration of percutaneously?蛳 inserted stent surface: an experimental study in swine[J].journal interventional radiology,2013,(05):403-408.
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小肠黏膜下层促进经皮血管腔内支架植入术后内皮化的实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年05期
页码:
403-408
栏目:
实验研究
出版日期:
2013-05-22

文章信息/Info

Title:
 The promotion effect of small intestinal submucous layer on the endothelial regeneration of percutaneously?蛳 inserted stent surface: an experimental study in swine
作者:
李景雷 王晓白 乔宏宇 张 红 张 艳 洪晓涛 
Author(s):
 LI Jing?蛳 lei WANG Xiao?蛳 bai QIAO Hong?蛳 yu ZHANG Hong ZHANG Yan HONG Xiao?蛳 tao.
 Department of Radiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
关键词:
 【关键词】 再狭窄 小肠黏膜下层 内皮细胞 经皮血管腔内支架植入术 动物实验
文献标志码:
A
摘要:
 【摘要】 目的 探讨小肠黏膜下层(SIS)促进支架表面内皮化在预防经皮血管腔内支架植入术(PTS)后再狭窄的价值。方法 14头猪经颈动脉球囊过度扩张双侧髂动脉后,随机选取一侧髂动脉植入裸支架(bare stent,BS),对侧髂动脉植入SIS覆膜支架(SCS)。于4、8、12周分别对4、5、5头猪进行造影复查,并处死,对支架段标本行病理组织学及扫描电镜观察。结果 14头猪(28支髂动脉)共成功植入14枚BS及14枚SCS支架。复查造影示,8周时SCS组和BS组各有1支动脉闭塞,其余26枚支架均通畅,4、8、12周时SCS组再狭窄率与BS组比较差异均无统计学意义(P < 0.05)。免疫组化示4、8、12周时SCS组增殖细胞核抗原阳性细胞平均百分率均明显低于BS组(P < 0.05);电镜见SCS组新生内膜内皮细胞数均高于BS组,组间差异有统计学意义(P < 0.05)。结论 SIS具有促进内皮细胞再生及支架表面内皮化的作用,可间接抑制血管平滑肌细胞增殖,并促进合成型平滑肌细胞向收缩型转变的作用。

参考文献/References:

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备注/Memo

备注/Memo:
 (收稿日期:2012-11-15)
更新日期/Last Update: