[1]朱海云,程永德,李跃华. 跨膜转运常数评价2型糖尿病患者下肢肌肉微循环状况[J].介入放射学杂志,2012,(07):547-550.
　ZHU Hai- yun,CHENG Yong- de,LI Yue-hua.. Evaluation of microcirculatory status of lower limb muscles by using K- trans in patients with type 2 diabetes[J].journal interventional radiology,2012,(07):547-550.
点击复制

 跨膜转运常数评价2型糖尿病患者下肢肌肉微循环状况 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年07期
页码:
547-550
栏目:
血管介入
出版日期:
2012-07-30

文章信息/Info

Title:
 Evaluation of microcirculatory status of lower limb muscles by using K- trans in patients with type 2 diabetes
作者:
 朱海云;  程永德;  李跃华
Author(s):
 ZHU Hai- yun;  CHENG Yong- de;  LI Yue-hua.
 Department of Radiology， No.85 Hospital of PLA， Shanghai 200052， China
关键词:
 ; 【关键词】 2型糖尿病;  磁共振成像;  微循环;  糖尿病足
文献标志码:
A
摘要:
 【摘要】 目的 通过动态对比增强磁共振成像（DCE?蛳 MRI）量化正常人和糖尿病患者经皮血管成形术（PTA）治疗前和治疗后的肌肉微循环状况。方法 收集25例2型糖尿病下肢血管闭塞患者，并选择体重指数相匹配的30名健康志愿者作为对照组，通过DCE?蛳 MRI扫描获得比目鱼肌（SOL）和胫前肌（TA）的跨膜转运常数（K?蛳 trans）值，比较两组间的差异，并记录糖尿病患者在股动脉PTA治疗前、后SOL、TA的K?蛳 trans值变化。结果 对照组TA和SOL的K?蛳 trans值均高于糖尿病组，分别为0.018/0.018比0.009/0.006和0.026/0.021比0.012/0.011，组间差异有统计学意义（P < 0.001）。糖尿病患者的K?蛳 trans值在PTA治疗后增加，与治疗前比较差异有统计学意义（P < 0.001）。结论 糖尿病患者的K?蛳 trans值下降，在PTA治疗后有所改善。K?蛳 trans可以量化下肢肌肉微循环变化，并可用于检测正常人SOL和TA的差异。

参考文献/References:

［1］   Chao CY， Cheing GL. Microvascular dysfunction in diabetic foot disease and ulceration［J］. Diabetes Metab Res Rev， 2009， 25： 604 ?蛳 614.
［2］   Henderson EA. Role of diabetic microvascular disease in the development of foot wounds［J］. J Wound Care， 2007， 16： 275 ?蛳 278.
［3］   Khaodhiar L， Dinh T， Schomacker KT， et al. The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes［J］. Diabetes Care， 2007， 30： 903 ?蛳 910.
［4］   Greenman RL， Panasyuk S， Wang X， et al. Early changes in the skin microcirculation and muscle metabolism of the diabetic foot［J］. Lancet， 2005， 366： 1711 ?蛳 1717.
［5］  Faranesh AZ， Kraitchman DL， Mcveigh ER. Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent［J］. Magn Reson Med， 2006， 55： 1114 ?蛳 1123.
［6］  Murase K. Efficient method for calculating kinetic parameters using T1?蛳 weighted dynamic contrast?蛳 enhanced magnetic resona?蛳nce imaging［J］. Magn Reson Med， 2004， 51： 858 ?蛳 862.
［7］  Resnick HE， Foster GL， Bardsley J， et al. Achievement of American diabetes association clinical practice recommendations among U.S adults with diabetes， 1999- 2002： the National Health and Nutrition Examination Survey［J］ .Diabetes Care， 2006， 29： 531 ?蛳 537.
［8］  Pentecost MJ， Michael HC， Dorros G， et al. Guidelines for peripheral percutaneous transluminal angioplasty of the abdominal aorta and lower extremity vessels［J］. Circulation， 2003， 14： S495 ?蛳 S515.
［9］   Hile C， Veves A. Diabetic neuropathy and microcirculation［J］. Curr Diab Rep， 2003， 3： 446 ?蛳 451.
［10］ Endo MY， Kobayakawa M， Kinugasa R， et al. Thigh muscle activation distribution and pulmonary VO2 kinetics during moderate， heavy， and very heavy intensity cycling exercise in humans［J］. Am J Physiol Regul Integr Comp Physiol， 2007， 293： R812 ?蛳 R820.
［11］ Stanisz GJ， Henkelman RM. Gd?蛳 DTPA relaxivity depends on macromolecular content［J］. Magn Reson Med， 2000， 44： 665 ?蛳 667.
［12］ Su MY， Mühler A， Lao X， et al. Tumor characterization with dynamic contrast?蛳 enhanced MRI using Mr contrast agents of various molecular weights［J］. Magn Reson Med， 1998， 39： 259 ?蛳 269.
［13］ Vincensini D， Dedieu V， Renou JP， et al. Measurements of extracellular volume fraction and capillary permeability in tissues using dynamic spin?蛳 lattice relaxometry： studies in rabbit muscles［J］. Magn Reson Imaging， 2003， 21： 85 - 93.

相似文献/References:

[1]张 琳,黄学全,王健,等.自主研发电化学治疗同轴电极与传统针式电极电解效应的对比研究[J].介入放射学杂志,2012,(02):148.
　ZHANG Lin,HUANG Xue-quan,WANG Jian,et al.The electrolytic effect in electrochemotherapy: a comparative study between self-prepared coaxial electrode and conventional needle electrode[J].journal interventional radiology,2012,(07):148.
[2]赵 玮,王伟中,陈莹,等.耳部动静脉畸形供血动脉的血管造影研究[J].介入放射学杂志,2012,(02):103.
　ZHAO Wei,WANG Wei-zhong,CHEN Ying,et al.Angiographic findings of the feeding arteries of auricular arteriovenous malformations[J].journal interventional radiology,2012,(07):103.
[3]邹俊民,龙世娟,张振明. 改良髂内动脉化疗联合放疗治疗Ⅲ~Ⅳa期 子宫颈癌32例[J].介入放射学杂志,2012,(02):123.
　ZOU Jun-min,LONG Shi-Juan,ZHANG Zheng-ming..Improved internal iliac artery chemotherapy combined with radiotherapy for the treatment of stage Ⅲ-Ⅳa cervical cancers[J].journal interventional radiology,2012,(07):123.
[4]王昌明,李 选,宋世兵,等.肝门部胆道引流管折叠技术在肝移植后胆道非吻合口狭窄治疗中的应用[J].介入放射学杂志,2012,(02):136.
　WANG Chang-ming,LI Xuan,SONG Shi-bing,et al.The application of biliary catheter folding technique in the treatment of hilar nonanastomotic biliary strictures after orthotopic liver transplantation[J].journal interventional radiology,2012,(07):136.
[5]赵玉峰,孙玉琴,韩晓静,等. 输卵管介入再通术后受孕时机的研究[J].介入放射学杂志,2012,(02):158.
　ZHAO Yu-feng,SUN Yu-qin,HAN Xiao-jing,et al.The optimal time for conception after fallopian tube recanalization therapy[J].journal interventional radiology,2012,(07):158.
[6]含 笑,曹建民,史东宏,等.吉西他滨、顺铂动静脉联合化疗治疗晚期非小细胞肺癌的近期疗效分析[J].介入放射学杂志,2012,(02):119.
　HAN Xiao,CAO Jian-min,SHI Dong-hong,et al.Bronchial artery infusion of Gemcitabine and Cisplatin combined with systemic chemotherapy for advanced non-small cell lung cancer: its short-term efficacy[J].journal interventional radiology,2012,(07):119.
[7]姚雪松,李 槐.不可手术切除的肝细胞癌的疗效评价标准——改良ＲＥＣＩＳＴ标准更可靠[J].介入放射学杂志,2012,(03):177.
　. Ｔｈｅｒａｐｅｕｔｉｃ ｅｖａｌｕａｔｉｏｎ ｃｒｉｔｅｒｉｏｎ ｏｆ ｉｎｏｐｅｒａｂｌｅ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ｍｏｄｉｆｉｅｄ ＲＥＣＩＳＴ ａｓ ａ ｍｏｒｅ ｒｅｌｉａｂｌｅ ｓｔａｎｄａｒｄ[J].journal interventional radiology,2012,(07):177.
[8]齐 立,李慎茂,俸军林,等. 动脉溶栓与机械碎栓联合动脉溶栓的对比分析[J].介入放射学杂志,2012,(03):180.
　,,et al. Ｃｏｍｐａｒｉｓｏｎ ｏｆ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｉｃａｃｙ ｂｅｔｗｅｅｎ ｓｉｍｐｌｅ ａｒｔｅｒｉａｌ ｔｈｒｏｍｂｏｌｙｓｉｓ ａｎｄ ｍｅｃｈａｎｉｃａｌ ｔｈｒｏｍｂｅｃｔｏｍｙ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ａｒｔｅｒｉａｌ ｔｈｒｏｍｂｏｌｙｓｉｓ ｆｏｒ ａｃｕｔｅ ｃｅｒｅｂｒａｌ ｉｎｆａｒｃｔｉｏｎ ａｔ ｉｔｓ ｕｌｔｒａｅａｒｌｙ ｓｔａｇｅ[J].journal interventional radiology,2012,(07):180.
[9]石 潆,赵 卫,沈 进,等.脑动静脉畸形栓塞治疗术并发颅内出血的原因及处理[J].介入放射学杂志,2012,(03):185.
　,,et al.Ｉｎｔｒａｃｒａｎｉａｌ ｈｅｍｏｒｒｈａｇｅ ｄｕｅ ｔｏ ｅｍｂｏｌｉｚａｔｉｏｎ ｔｈｅｒａｐｙ ｆｏｒ ｃｅｒｅｂｒａｌ ａｒｔｅｒｉｏｖｅｎｏｕｓ ｍａｌｆｏｒｍａｔｉｏｎ： ｉｔｓ ｃａｕｓｅｓ ａｎｄ ｍａｎａｇｅｍｅｎｔ [J].journal interventional radiology,2012,(07):185.
[10]周 慷,李晓光,金征宇,等.清宫术前子宫动脉化疗栓塞术治疗瘢痕妊娠的疗效分析[J].介入放射学杂志,2012,(03):190.
　,,et al.Ｔｈｅｒａｐｅｕｔｉｃ ａｎａｌｙｓｉｓ ｏｆ ｂｉｌａｔｅｒａｌ ｕｔｅｒｉｎｅ ａｒｔｅｒｙ ｃｈｅｍｏｅｍｂｏｌｉｚａｔｉｏｎ ｐｅｒｆｏｒｍｅｄ ｂｅｆｏｒｅ ｕｔｅｒｉｎｅ ｄｉｌａｔｉｏｎ ａｎｄ ｃｕｒｅｔｔａｇｅ ｆｏｒ ｃｅｓａｒｅａｎ ｓｃａｒ ｐｒｅｇｎａｎｃｙ [J].journal interventional radiology,2012,(07):190.
[11]朱海云,柏 挺,张永秋,等. 糖尿病足介入治疗的荟萃分析[J].介入放射学杂志,2013,(09):718.
　ZHU Hai? yun,BAI Ting,ZHANG Yong? qiu,et al. Interventional therapies for diabetic foot： a meta?蛳 analysis[J].journal interventional radiology,2013,(07):718.

备注/Memo

备注/Memo:
 （收稿日期：2012-03-02）
更新日期/Last Update: