[1]田 浩,徐浩,祖茂衡,等.MTHFR C677T多态性、血浆Hcy及青年肝静脉型布-加综合征的相关性研究[J].介入放射学杂志,2012,(01):62-65.
 TIAN Hao,XU Hao,ZU Mao heng,et al.Correlation of MTHFR C677T gene polymorphism plasma and Hcy levels in young patients with hepatic vein obstruction[J].journal interventional radiology,2012,(01):62-65.
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MTHFR C677T多态性、血浆Hcy及青年肝静脉型布-加综合征的相关性研究

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年01期
页码:
62-65
栏目:
实验研究
出版日期:
2012-01-30

文章信息/Info

Title:
Correlation of MTHFR C677T gene polymorphism plasma and Hcy levels in young patients with hepatic vein obstruction
作者:
 田 浩徐浩祖茂衡裴冬生
Author(s):
TIAN Hao XU Hao ZU Mao heng PEI Dong sheng.
Department of Oncology, Xinyi Municipal People's Hospital, Xinyi, Jiangsu Province 221400, China
关键词:
 【关键词】布加综合征 同型半胱氨酸血症 亚甲基四氢叶酸还原酶
文献标志码:
A
摘要:
【摘要】 目的 研究5,10亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性、血浆高同型半胱氨酸(Hcy)及青年肝静脉型布加综合征(BCS)的相关性。方法 研究组青年肝静脉型BCS患者60例,对照组为健康志愿者60名,免疫荧光法测空腹血浆Hcy浓度 全血提取DNA基因组,聚合酶链反应限制性内切酶片段长度多态性技术(PCRRFLP)检测 MTHFR基因第677位点基因多态性 结果 BCS组血浆Hcy浓度为(20.38 ± 8.40)μmol/L,MTHFR 677位点多态性纯合子(TT型)突变率为35.0%(21/60),明显高与对照组的(16.64 ± 5.16)μmol/L和16.7%(10/60),两组间差异均有统计学意义(P = 0.001, P = 0.03)。结论 青年肝静脉型BCS血浆存在高Hcy浓度状态,MTHFR C677T基因的纯合子突变与高Hcy血症有相关性。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2011-09-17)
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