[1]孙高峰,田建明,叶风平,等.CT引导下热化疗对猪胰腺影响的实验研究[J].介入放射学杂志,2007,(12):844.
 SUN Gao-feng,TIAN Jian-ming,YE Feng-ping,et al.Experimental research of CT-guided thermochemotherapy for pig's healthy pancreas[J].journal interventional radiology,2007,(12):844.
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CT 引导下热化疗对猪胰腺影响的实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2007年12期
页码:
844
栏目:
实验研究
出版日期:
2007-12-15

文章信息/Info

Title:
Experimental research of CT-guided thermochemotherapy for pig's healthy pancreas
作者:
孙高峰田建明叶风平
200433上海第二军医大学长海医院放射科
Author(s):
SUN Gao-fengTIAN Jian-mingYE Feng-pingZHANG FengZHANG Chang-baoWANG Jian-hua.
Imaging Department of Changhai Hospital,Second Military Medical University,Shanghai200433,China
关键词:
胰腺热化疗CT
分类号:
R735.9
文献标志码:
A
摘要:
目的探讨CT引导下热化疗治疗胰腺癌的可行性、安全性及疗效。方法正常家猪9头,CT引导下将18G穿刺针穿入小猪胰腺尾部。5-FU注射液750mg加热至80℃,维持时间不低于0.5h,2min内注入,按不同时间段分组,定期复查CT及MRI,并抽血化验血清淀粉酶,把不同时间段的大体病理与影像资料进行对比。结果经过CT引导下5-FU热化疗治疗后,正常小猪胰腺尾部均出现灶性坏死,第3、7和15d的大体病理与影像学表现吻合较好,实验小猪未出现肠粘连、梗阻等严重并发症。术后1h、3、7和15d复查血清淀粉酶,以第3天最高,其后为1h和第7天,到第15天降至正常。结论对于晚期胰腺癌患者,CT引导下热化疗可能为一种安全有效的治疗方法。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-09-18
基金项目:上海市科委基金(054119637);本课题为上海市领军人才资金(LJ06006)
更新日期/Last Update: 2007-12-15