[1]吕维富,胡曙东,王伟昱,等.经皮肝穿刺胆管鄄胃引流治疗梗阻性黄疸动物实验[J].介入放射学杂志,2007,(04):269.
 LvWei-fu,HU Shu-dong,WANG Wei-yu,et al.Animal experimental study of percutaneous transhepatic cholangiogastric drainage for the management of biliary tract obstruction[J].journal interventional radiology,2007,(04):269.
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经皮肝穿刺胆管鄄胃引流治疗梗阻性黄疸动物实验()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2007年04期
页码:
269
栏目:
实验研究
出版日期:
2007-04-15

文章信息/Info

Title:
Animal experimental study of percutaneous transhepatic cholangiogastric drainage for the management of biliary tract obstruction
作者:
吕维富胡曙东王伟昱
230001合肥安徽省立医院影像科
Author(s):
LvWei-fuHU Shu-dongWANG Wei-yuZHANG Xue-binHOU Chang-longZHANG Xing-ming.
Department of Radiology,Anhui Provincial Hospital,Hefei230001,China
关键词:
胆管阻塞内引流术放射学介入性动物实验研究
分类号:
R735.8
文献标志码:
A
摘要:
目的探讨经皮肝穿刺胆管-胃引流(PTCGD)治疗顽固性胆道梗阻黄疸的可行性、安全性和有效性。方法健康杂种家猪20只,行胆总管结扎,建立梗阻性黄疸动物模型。动物于术后14d随机分成两组:①PTCGD组(A组,n=10):行PTCGD,置入内引流管。②对照组(B组,n=10):在胆总管结扎后不予治疗。两组在不同时间段内观察血清总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸转氨酶(ALT),白蛋白(ALB)变化,比较2组间及内引流前后差异,观察肝脏病理学和影像学改变。结果A组技术成功率为100%,行PTCGD后肝内胆管扩张明显减轻,肝功能显著改善,病理表现显示肝组织明显修复好转。B组动物分别死于胆总管结扎术后23~32d,TBIL、DBIL、ALT在胆总管结扎后持续升高,并且随梗阻时间延长逐步加重,胆管造影显示肝内外胆管重度扩张,病理显示肝小叶出现大片状坏死,小叶间胆管胆汁淤滞,扩张明显,肝细胞崩解。结论PTCGD是梗阻性黄疸动物模型,特别是常规介入放射学技术不能成功的顽固性胆道梗阻又一较为安全、有效、微创的治疗方法。

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备注/Memo

备注/Memo:
收稿日期:2005-08-01
更新日期/Last Update: 2007-04-15