[1]朱悦琦,程英升,李明华,等.暂时性自膨胀贲门支架治疗犬贲门失弛缓症模型的 实验研究[J].介入放射学杂志,2011,(06):459.
 ZHU Yue-qi,CHENG Ying-sheng,LI Ming-hua,et al.Temporary self-expanding cardia stents for the treatment of achalasia: an experimental study in dogs[J].journal interventional radiology,2011,(06):459.
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暂时性自膨胀贲门支架治疗犬贲门失弛缓症模型的 实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年06期
页码:
459
栏目:
实验研究
出版日期:
2011-06-30

文章信息/Info

Title:
Temporary self-expanding cardia stents for the treatment of achalasia: an experimental study in dogs
作者:
朱悦琦 程英升 李明华 赵俊功 李 烽 陈尼维
Author(s):
ZHU Yue-qi CHENG Ying-sheng LI Ming-hua ZHAO Jun-gong LI Feng CHEN Ni-wei.
Department of Radiology, the Sixth Affiliated People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200233, China
关键词:
贲门失弛缓症 支架 炎症
分类号:
R573.7
文献标志码:
摘要:
目的 评价应用暂时性可回收贲门覆膜支架(TRCCS)治疗犬贲门失迟缓症模型的有效性并探讨理想的回收时间。方法 84条贲门失弛缓症模型犬随机分为7组(每组12条):对照组(CG;无支架置入)、标准支架置入组(NSCG;标准食管支架)和5组治疗组(TGs)置入(TRCCS)。NSCG支架置入后4 d取出,5组TGs支架分别在4 d(4 dTG)、2周(2 wTG)、1个月(1 mTG)、3个月(3 mTG)和6 个月(6 mTG)取出。支架置入前、支架取出后和1周,1、3和6个月随访时分别行食管下段括约肌压力(LESP)测试和时间钡餐检查进行疗效评价。NSCG和4 dTG组在每个随访点各处死3条犬行组织病理学检查评价支架置入后的炎症反应。结果 支架置入和取出以及随访过程中所有犬均能很好耐受。在6个月随访结束时,2 wTG和1 mTG组表现出较低的支架移位率(n = 2),而NSCG和3 mTG组各有4只犬支架移位,6 mTG组有6只犬支架移位。与建模后相比,2 wTG和1mTG组的LESP(P < 0.05)和钡餐高度(P = 0.014 4和0.040 9)都有明显的改善。增殖细胞核抗原(PCNA)和抗α平滑肌动蛋白抗原免疫组化染色提示NSCG和4 dTG组在各不同随访点的炎症反应没有明显差异。结论 TRCCS置入可以有效治疗犬贲门失迟缓症模型。LESP和时间钡餐检查提示理想的支架回收时间在2周 ~ 1个月。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:20101022
更新日期/Last Update: 2011-06-30