[1]董 生,袁 正,吴胜伟,等.碳纳米管 -聚氨酯复合膜的力学特性及生物相容性初步研究[J].介入放射学杂志,2011,(02):127-130.
 DONG Sheng,YUAN Zheng,WU Sheng-wei,et al.The mechanics and biocompatibility characteristics of carbon nanotubes-polyurethane composite membranes: a preliminary study[J].journal interventional radiology,2011,(02):127-130.
点击复制

碳纳米管 -聚氨酯复合膜的力学特性及生物相容性初步研究()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年02期
页码:
127-130
栏目:
实验研究
出版日期:
2011-03-15

文章信息/Info

Title:
The mechanics and biocompatibility characteristics of carbon nanotubes-polyurethane composite membranes: a preliminary study
作者:
董 生 袁 正 吴胜伟 李文新
200003 上海 第二军医大学长征医院放射科; 南京军区南京总医院放射科;中国科学院上海医用物理研究所
Author(s):
DONG Sheng YUAN Zheng WU Sheng-wei LI Wen-xin.
Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
关键词:
碳纳米管 聚氨酯 力学特征 生物相容性 支架
分类号:
R197.39
文献标志码:
A
摘要:
目的   探讨碳纳米管聚氨酯复合膜的力学特性和生物相容性。方法   将经超声处理的碳纳米管与聚氨酯混合制成复合膜,用万能材料试验机检测不同质量比的复合膜的力学特性,在支架弯曲90°时电镜观察膜的表面,将不同含量的复合膜溶液与人肝癌细胞7721细胞培养进行细胞毒性试验,用浸涂法制备碳纳米管聚氨酯覆膜金属支架,并置入兔食管进行活体评价。结果   碳纳米管含量为0、0.1%、0.3%和0.5%时,对应的复合膜拉伸强度(MPa)和复合膜断裂延长率(%)分别为:4.62/900、6.05/730、8.26/704、5.7/450。支架弯曲90°,用电镜扫描表面光整,未见裂痕。当碳纳米管含量为0.5%和1.0%时,对细胞生长有明显抑制作用。在兔食管放置30 d后碳纳米管聚氨酯复合膜未见裂纹、老化降解等现象。结论   添加适量的碳纳米管的聚氨酯膜能改善复合膜的力学特性,同时有较好的生物相容性。

参考文献/References:

[1] Ruygrok PN. The Coherex Flat Stent: an advance in patent foramen ovale closure[J]. Expert Rev Med Devices, 2010, 7: 193 - 199.
[2] Radeleff B, Grenacher L, Christoph P. Comparison of a microporous thermoplastic polyurethane-covered stent with a self-expanding bare nitinol stent in a porcine iliac artery model[J]. J Vasc Interv Radiol, 2009, 20: 927 - 935.
[3] Schuman E, Babu J. Sirolimus-loaded polyurethane graft for hemodialysis access in sheep[J]. Vascular, 2008, 16: 269 - 274.
[4] Anderson JM, Hiltner A, Wiggins MJ, et al. Recent advances in biomedical polyurethane biostability and biodegradation[J]. Polymer International, 1998, 46: 163.
[5] Xu Y, Mahmood M, Fejleh A, et al. Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells[J]. Int J Nanomedicine, 2010, 7: 167 - 176.
[6] Szelest-Lewandowska A, Masiulanis B, Szymonowicz M, et al. Modified polycarbonate urethane: synthesis, properties and biological investigation in vitro[J]. J Biomed Mater Res A, 2007, 82: 509 - 520.
[7] Misra SK, Ansari TI, Valappil SP, et al. Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications[J]. Biomaterials, 2010, 31: 2806 - 2815.
[8] Chai BJ, Covina W, Fred D, et al. Method of preparing phosphonates from nitriles[J]. United States Patent US4239695. 1980212216.
[9] Feng L, Andrade JD. Protein adsorption on low temperature isotropic carbon[J]. J Biomater Sci Polym Ed, 1995, 7: 439 - 452.
[10] Singh AK, Sadrzadeh A, Yakobson BI. Metallacarboranes: toward promising hydrogen storage metal organic frameworks[J]. J Am Chem Soc, 2010, 13: 14126 - 14129.
[11] Yasutake M, Shirakawabe Y, Okawa T, et al. Performance of the carbon nano-tube assembled tip for surface shape characterization[J].Ultramicroscopy, 2002, 91:57 - 62.
[12] 郭金学, 李宇国, 吴胜伟, 等. CNTs化学修饰的γ剂量研究[J]. 辐射研究与辐射工艺学报, 2005, 23: 112.

备注/Memo

备注/Memo:
收稿日期:20100827
国际自然科学基金(30270418);上海市科委重点纳米专项基金(0452nm037)
更新日期/Last Update: 2011-03-15