[1]姚志敏,佟小强,宋莉,等.宫颈癌术前动脉化疗栓塞疗效[J].介入放射学杂志,2009,(03):189.
　YAO Zhimin,TONG Xiaoqiang,SONG Li,et al.Preoperative transarterial chemoembolization for cervical cancer：analysis of efficacy[J].journal interventional radiology,2009,(03):189.
点击复制

宫颈癌术前动脉化疗栓塞疗效()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年03期
页码:
189
栏目:
肿瘤介入
出版日期:
2009-03-15

文章信息/Info

Title:
Preoperative transarterial chemoembolization for cervical cancer：analysis of efficacy
作者:
姚志敏; 佟小强; 宋莉; 等
１０００３４北京大学第一医院介入血管外科
Author(s):
YAO Zhi－min; TONG Xiao－qiang; SONG Li ; ZOU Ying－hua
Department of Interventional Radiology＆Vascular Surgery，the First Affiliated Hospital，Beijing University，Beijing１０００３４，China
关键词:
宫颈癌; 经动脉化疗栓塞; 病理; 新辅助化疗
分类号:
R７３７.３３
文献标志码:
A
摘要:
目的研究局部进展期宫颈癌术前子宫动脉化疗栓塞的疗效及病理改变。方法经阴道镜活检证实宫颈癌患者４３例，其中鳞癌３８例，腺癌５例；FIGO临床分期ⅠB２期１４例，ⅡA期５例，ⅡB期２３例，ⅢB期１例。所有患者均进行１次子宫动脉化疗栓塞，化疗药物为博莱霉素＋顺铂＋异环磷酰胺，栓塞剂为明胶海绵颗粒。其后择期行子宫广泛切除加盆腔淋巴结清扫术，分析手术及病理所见。结果①介入治疗后CR４例，PR２９例，总有效率为７６．７％。②介入治疗与外科手术间隔时间为肿瘤治疗无效的风险因素，即随着间隔时间延长介入疗效下降。③术后病理显示，镜下表现为肿瘤细胞退行性变，凋亡，肿瘤组织结构松散，周边及肿瘤内大量炎细胞浸润，纤维组织增生，部分病例镜下未见肿瘤细胞。宫旁浸润率减低，部分肿瘤分期逆转，术后病理与术前病理比较１０例分化程度降低，５例术后未见肿瘤或残余个别肿瘤细胞而不能判定分化，９例分化程度增高，１９例无变化。结论子宫动脉化疗栓塞用于宫颈癌根治新辅助化疗安全有效，可在短期内有效控制肿瘤生长，并可能降低临床分期，有利于肿瘤根治切除。介入治疗后应尽早择期进行手术而不宜过于延长间隔时间。

参考文献/References:

［１］蔡丽萍，龚沂．宫颈癌新辅助化疗中动脉介入化疗现状［J］．肿瘤学杂志，２００７，１３：１１７－１１８．
［２］Janicek MF ，Averette HE．Cervical cancer：prevention，diagnosis，and therapeutics［J］．CA Cancer J Clin，２００１，５１：９２－１１４．
［３］Waggoner SE．Cervical cancer［J］．Lancet，２００３，３６１：２２１７－２２２５．
［４］Supraser

相似文献/References:

[1]李晓光,金征宇,杨宁,等.经动脉灌注化疗或栓塞治疗恶性胰岛素瘤肝转移[J].介入放射学杂志,2008,(11):803.
　LI Xiaoguang,JIN Zhengyu,YANG Ning,et al.Transcatheter arterial chemoperfusion or chemoembolizaiton for treatment of liver metastasis from malignant insulinoma[J].journal interventional radiology,2008,(03):803.
[2]朱军,罗剑钧,张雯,等.经导管化疗栓塞联合放疗治疗中晚期宫颈癌[J].介入放射学杂志,2010,(03):194.
　ZHU Jun,LUO Jianjun,ZHANG Wen,et al.Transcatheter arterial chemoembolization combined with radiotherapy for the treatment of advanced cervical cancer[J].journal interventional radiology,2010,(03):194.
[3]吴宁,杨进全,林道仲,等.宫颈癌髂内动脉灌注栓塞近期疗效分析[J].介入放射学杂志,1997,(01):47.
[4]朱赤,张德志,曹立宇,等.超选择性子宫动脉化疗栓塞治疗宫颈癌的临床价值[J].介入放射学杂志,2009,(07):507.
　ZHU Chi,ZHANG Dezhi,CAO Liyu,et al.Super－selective uterine artery chemoembolization for the treatment of cervical cancer：its clinical value[J].journal interventional radiology,2009,(03):507.
[5]韩志刚,张国福,谢洁林,等.Ⅰｂ２ ～ Ⅱａ期宫颈癌根治性子宫切除术前子宫动脉栓塞化疗及髂内动脉前干支化疗的疗效比较[J].介入放射学杂志,2010,(12):955.
　HAN Zhi-gang,ZHANG Guo-fu,XIE Jie-lin,et al. Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages Ⅰb2-Ⅱa cervical cancer[J].journal interventional radiology,2010,(03):955.
[6]张 建,胡 兴,孙亚军,等.子宫动脉化疗栓塞治疗宫颈癌33例临床分析[J].介入放射学杂志,2011,(04):303.
　ZHANG Jian,HU Xing,SUN Ya-jun,et al.Superselective uterine artery chemoembolization for the treatment of cervical cancer a clinical analysis of 33 cases[J].journal interventional radiology,2011,(03):303.
[7]张琳,牟玮,王健,等.乙酸化学消融联合肝动脉化疗栓塞治疗肝脏恶性肿瘤[J].介入放射学杂志,2007,(12):831.
　ZHANG Lin,MU Wei,WANG Jian,et al.CT fluoroscopic guidance percutaneous acetic acid injection tumor ablation and TACE for the malignant liver tumor[J].journal interventional radiology,2007,(03):831.
[8]杨学刚,周 石,李政文,等.不同途径新辅助化疗治疗年轻宫颈癌的疗效比较[J].介入放射学杂志,2015,(04):342.
　YANG Xue gang,ZHOU Shi,LI Zheng wen,et al.Neoadjuvant chemotherapy via different approaches for the treatment of cervical carcinoma in young female patients： comparison of the therapeutic effect[J].journal interventional radiology,2015,(03):342.
[9]王惠文,刘瑞宝,李晓婧,等.载药微球-TACE治疗难治性妇科恶性肿瘤肝转移12例[J].介入放射学杂志,2021,30(06):568.
　WANG Huiwen,LIU Ruibao,LI Xiaojing,et al.Drug- eluting beads - TACE for the treatment of refractory liver metastases from synecological malignant tumors： preliminary results in 12 patients[J].journal interventional radiology,2021,30(03):568.

备注/Memo

备注/Memo:
收稿日期：２００８－１２－２５
更新日期/Last Update: 2009-03-15