参考文献/References:
［１］The National Institute of Neurological Disorders and Stroke rt－PA Stroke Study Group．Tissue plasminogen activator for acute ischemic stroke［J］．N Engl J Med，１９９５，３３３：１５８１－１５８７．
［２］Hacke W，Kaste M，Fieschi C，et al．Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke［J］．The European Cooperative Acute Stroke Study（ECASS）．JAMA，１９９５，２７４：１０１７－１０２５．
［３］Heuschmann PU，Kolominsky－Rabas PL，Roether J，et al，German Stroke Registers Study Group．Predictors of in－hospital mortality in patients with acute ischemic stroke treated with thrombolytic therapy［J］．JAMA，２００４，２９２：１８３１－１８３８．
［４］Rogalewski A，Schneider A，Ringelstein EB，et al．Toward a multimodal neuroprotective treatment of stroke［J］．Stroke，２００６，３７：１１２９－１１３６．v［５］Belayev L，Liu Y，Zhao W，et al．Human albumin therapy of acute ischemic stroke：marked neuroprotective efficacy at moderate doses and with a broad therapeutic window［J］．Stroke，２００１，３２：５５３－５６０．
［６］Yang Y，Li Q，Ahmad F，et al．Survival and histological evaluation of therapeutic window of post－ischemia treatment with magnesium sulfate in embolic stroke model of rat［J］．Neurosci Lett，２００３，２８５：１１９－１２２．
［７］李永东，赵俊功，李明华，等．急性血栓性大脑中动脉栓塞脑缺血模型的建立［J］．介入放射学杂志，２００８，１７：１２２－１２８．
［８］Pfefferkorn T，Rosenberg GA．Closure of the blood－brain barrier by matrix metalloproteinase inhibition reduces rtPA－mediated mortality in cerebral ischemia with delayed reperfusion［J］．Stroke，２００３，３４：２０２５－２０３０．
［９］Huh PW，Belayev L，Zhao W，et al．The effect of high－dose albumin therapy on local cerebral perfusion after transient focal cerebral ischemia in rats［J］．Brain Res，１９９８，８０４：１０５－１１３．
［１０］Belayev L，Busto R，Zhao W，et al．Effect of delayed albumin hemod－ilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats［J］．J Neuro－surg，１９９７，８７：５９５－６０１．
［１１］Sirin BH，Coskun E，Yilik L，et al．Neuroprotective effects of preischemia subcutaneous magnesium sulfate in transient cerebral ischemia［J］．Eur J Cardiothorac Surg，１９９８，１４：８２－８８．
［１２］李明华，赵俊功，程英升，等．延长急性脑缺血溶栓时间窗的实验研究［J］．介入放射学杂志，２００５，１４：５１０－５１５．
［１３］赵俊功，李明华，程英升，等．大鼠急性脑梗死后不同区域扩散和灌注成像的变化特点［J］．介入放射学杂志，２００５，１４：５１６－５２２．
［１４］Candelario－Jalil E，Gonzalez－Falcon A，Garcia－Cabrera M，et al．Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat［J］．Brain Res，２００４，１００７：９８－１０８．
［１５］Hacke W，Brott T，Caplan L，et al．Thrombolysis in acute ischemic stroke：controlled trials and clinical experience［J］．Neurology，１９９９，５３：S３－S１４．
［１６］del Zoppo GJ．Clinical trials in acute stroke：why have they not been successful ［J］．Neurology，１９９８，５１：S５９－S６１．
［１７］Dyker AG，Lees KR．Duration of neuroprotective treatment for ischemic stroke［J］．Stroke，１９９８，２９：５３５－５４２．
［１８］Hickenbottom SL，Grotta J．Neuroprotective therapy［J］．Semin Neurol，１９９８，１８：４８５－４９２．
［１９］Ginsberg MD，Hill MD，Palesch YY，et al．The ALIAS Pilot Trial：a dose－escalation and safety study of albumin therapy for acute ischemic stroke－－I：Physiological responses and safety results［J］．Stroke，２００６，３７：２１００－２１０６．
［２０］Palesch YY，Hill MD，Ryckborst KJ ，et al．The ALIAS Pilot Trial：a dose－escalation and safety study of albumin therapy for acute ischemic stroke－－II：neurologic outcome and efficacy analysis［J］．Stroke，２００６，３７：２１０７－２１１４．
［２１］Zhang L，Zhang ZG，Ding GL，et al．Multitargeted effects of statin－enhanced thrombolytic therapy for stroke with recombinant human tissue－type plasminogen activator in the rat［J］．Circulation，２００５，１１２：３４８６－３４９４．
［２２］Kristian T，Siesjo BK．Calcium in ischemic cell death［J］．Stroke，１９９８，２９：７０５－７１８．
［２３］Paoletti P，Neyton J，Ascher P．Glycine－independent and subunit－specific potentiation of NMDA responses by extracellular Mg
２＋
［J］．Neuron，１９９５，１５：１１０９－１１２０．
［２４］Westermaier T，Zausinger S，Baethmann A，et al．Dose finding study of intravenous magnesium sulphate in transient focal cerebral ischemia in rats［J］．Acta Neurochir（Wien），２００５，１４７：５２５－５３２．
［２５］Westermaier T，Hungerhuber E，Zausinger S，et al．Neuroprotective efficacy of intra－arterial and intravenous magnesium sulfate in a rat model of transient focal cerebral ischemia［J］．Acta Neurochir（Wien），２００３，１４５：３９３－３９９．
［２６］Ovbiagele B，Kidwell CS，Starkman S，et al．Neuroprotective agents for the treatment of acute ischemic stroke［J］．Curr Neurol Neurosci Rep，２００３，３：９－２０．
［２７］Muir KW．New experimental and clinical data on the efficacy of pharmacological magnesium infusions in cerebral infarcts［J］．Magnes Res，１９９８，１１：４３－５６．
［２８］Muir KW．Magnesium in stroke treatment ［J］．Postgrad Med J，２００２，７８：６４１－６４５．
［２９］Danton GH，Dietrich WD．The search for neuroprotective strategies in stroke［J］．AJNR，２００４，２５：１８１－１９４．
［３０］Marinov MB，Harbaugh KS，Hoopes PJ ，et al．Neuroprotective effects of preischemia intraarterial magnesium sulfate in reversible focal cerebral ischemia［J］．J Neurosurg，１９９６，８５：１１７－１２４．
［３１］Miles AN，Majda BT，Meloni BP，et al．Postischemic intravenous administration of magnesium sulfate inhibits hippocampal CA１neuronal death after transient global ischemia in rats［J］．Neurosurgery，２００１，４９：１４４３－１４５０．
［３２］Muir KW，Lees KR．Dose optimization of intravenous magnesium sulfate after acute stroke［J］．Stroke，１９９８，２９：９１８－９２３．
［３３］Aoki T，Sumii T，Mori T，et al．Blood－brain barrier disruption and matrix metallo－proteinase－９expression during reperfusion injury：mechanical versus embolic focal ischemia in sponta－neously hypertensive rats［J］．Stroke，２００２，３３：２７１１－２７１７．
［３４］Romanic AM，White RF，Arleth AJ ，et al．Matrix metallo－proteinase expression increases after cerebral focal ischemia in rats：inhibition of matrix metallo－proteinase－９reduces infarct size［J］．Stroke，１９９８，２９：１０２０－１０３０．
［３５］Sumii T，Lo EH．Involvement of matrix metalloproteinase in thrombolysis－associated hemorrhagic transformation after embolic focal ischemia in rats［J］．Stroke，２００２，３３：８３１－８３６．
［３６］吴旭东，曹小定．血脑屏障与脑缺血［J］．国外医学脑血管疾病分册，２０００，８：２７２－２７５．
［３７］李铃，黄如训，张小燕，等．局部脑缺血再灌注病灶区脑微血管基底膜及其成分改变的实验研究［J］．中华老年医学杂志，２０００，１９：３６４－３６７．
［３８］Montaner J，Molina CA，Monasterio J，et al．Matrix metalloproteinase－９pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke［J］．Circulation，２００３，１０７：５９８－６０３．
［３９］Rosenberg GA，Estrada EY，Dencoff JE．Matrix metallo－proteinases and TIMPs are associated with blood－brain barrier opening after reperfusion in rat brain［J］．Stroke，１９９８，２９：２１８９－２１９５．
［４０］Horstmann S，Kalb P，Koziol J，et al．Profiles of matrix metallo－proteinases，their inhibitors，and laminin in stroke patients：influence of different therapies［J］．Stroke，２００３，３４：２１６５－２１７０．
［４１］Belayev L，Saul I，Busto R，et al．Albumin treatment reduces neurological deficit and protects blood－brain barrier integrity after acute intracortical hematoma in the rat［J］．Stroke，２００５，３６：３２６－３３１
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