[1]王忠敏 黄钢 陈克敏 陆健 贡桔 郑云峰 张丽云.CT引导下~(125)I粒子植入治疗复发性直肠癌的临床应用[J].介入放射学杂志,2009,(09):681.
 WANG Zhang-min HUANG Gang CHEN Ke-min LU Jian GONG Ju ZHENG Yun-feng ZHANG Li-yun.Clinical application of CT-guided ~(125)I seed interstitial implantation for recurrent rectum carcinoma[J].journal interventional radiology,2009,(09):681.
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CT引导下~(125)I粒子植入治疗复发性直肠癌的临床应用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年09期
页码:
681
栏目:
非血管介入
出版日期:
2009-09-15

文章信息/Info

Title:
Clinical application of CT-guided ~(125)I seed interstitial implantation for recurrent rectum carcinoma
作者:
王忠敏 黄钢 陈克敏 陆健 贡桔 郑云峰 张丽云
王忠敏,陆健,贡桔,郑云峰,张丽云,WANG Zhang-min,LU Jian,GONG Ju,ZHENG Yun-feng,ZHANG Li-yun(上海交通大学医学院附属瑞金医院卢湾分院介入科,200020) 黄钢,HUANG Gang(上海交通大学医学院) 陈克敏,CHEN Ke-min(上海交通大学医学院附属瑞金医院放射科)
Author(s):
WANG Zhang-min HUANG Gang CHEN Ke-min LU Jian GONG Ju ZHENG Yun-feng ZHANG Li-yun
关键词:
直肠 复发肿瘤 CT引导 ~(125)I粒子 近距离治疗 rectum recurrent neoplasm CT-guidance ~(125)I seed brachytherapy
分类号:
R730.55
摘要:
目的 观察CT引导下~(125)I粒子植入治疗复发性直肠癌的安全性和临床疗效.方法 对20例直肠癌术后复发患者,在CT引导下植入~(125)I粒子治疗.术前采用治疗计划系统(TPS)重建肿瘤三维立体图像,计算出~(125)I粒子植入的粒子数目、空间分布和剂量率分布.~(125)I粒子的肿瘤匹配周边剂量(MPD)为80~130 Gy.粒子活度0.5~0.8 mCi/颗,中位植入粒子48颗(25~95颗).术后即刻行CT扫描进行粒子质量验证.观察全组患者疼痛缓解程度、肿瘤疗效评估和术后并发症.结果 治疗后随访2~28个月,平均术后3~7 d疼痛明显缓解.术后2个月CT随访,肿瘤完全缓解(CR)2例,部分缓解(PR)13例,无变化(NC)3例,进展(PD)2例,CR+PR为75%.全组中位生存期18.8个月.1、2年生存率分别为75%、25%.2例死于肿瘤恶化,3例死于全身广泛转移.全组患者随访期间未见尿频、尿痛、血尿、直肠出血、感染等并发症.结论 CT引导下植入~(125)I粒子治疗复发性直肠癌,近期疗效确切,具有较好的姑息止痛疗效,是一种安全、有效、并发症少的介入治疗方法.

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更新日期/Last Update: 2009-09-15