[1]鲁刚 黄磊 张晓龙 王盛章 万军 洪泳 胡宙 耿道颖.颅内动脉瘤壁切应力与动脉瘤破裂关系的初步研究——基于患者的三维计算机模拟[J].介入放射学杂志,2009,(08):568.
　LU Gang HUANG Lei ZHANG Xiao-long WANG Sheng-zhang WAN Jun HONG Yong HU Zhou GENG Dao-ying.Correlation between wall shear stress and the rupture of saccular intracranial aneurysms: the initial experimental results with patient-specific 3-D computational model[J].journal interventional radiology,2009,(08):568.
点击复制

颅内动脉瘤壁切应力与动脉瘤破裂关系的初步研究——基于患者的三维计算机模拟()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年08期
页码:
568
栏目:
神经介入
出版日期:
2009-08-15

文章信息/Info

Title:
Correlation between wall shear stress and the rupture of saccular intracranial aneurysms: the initial experimental results with patient-specific 3-D computational model
作者:
鲁刚 黄磊 张晓龙 王盛章 万军 洪泳 胡宙 耿道颖
鲁刚,黄磊,张晓龙,洪泳,胡宙,耿道颖,LU Gang,HUANG Lei,ZHANG Xiao-long,HONG Yong,HU Zhou,GENG Dao-ying(上海复旦大学华山医院放射科,200040) 王盛章,WANG Sheng-zhang(复旦大学力学与工程科学系) 万军,WAN Jun(静安区中心医院介入科)
Author(s):
LU Gang HUANG Lei ZHANG Xiao-long WANG Sheng-zhang WAN Jun HONG Yong HU Zhou GENG Dao-ying
关键词:
颅内动脉瘤 计算机流体力学 侧壁切应力
分类号:
R743.4
摘要:
目的 通过比较颅内无症状动脉瘤和症状动脉瘤的血流动力学参数,寻找与动脉瘤破裂有关的血流动力学因素.方法 5例患者DSA检查共发现8个颈内动脉动脉瘤,分别位于颈内动脉后交通段及颈眼动脉段.通过旋转DSA,重建动脉瘤三维模型,并使用有限体积法进行血流动力学数值模拟,比较不同组动脉瘤及载瘤动脉的血流动力学参数.两组数据对比时采用独立样本t检验,瘤颈与载瘤动脉比较使用配对t检验.结果 无症状组和症状组动脉瘤瘤颈部平均切应力分别为(5.54±2.89)Pa和(4.78±3.84)Pa,两组间差异无统计学意义(P=0.78);动脉瘤临近载瘤动脉平均切应力分别为(6.6±3.47)Pa和(7.30±3.80)Pa,两组间差异无统计学意义(P=0.80);动脉瘤低切应力区域的大小分别为0.33%和4.72%,两组间差异有统计学意义(P=0.01).结论 动脉瘤壁低切应力区域的大小可能是影响颅内囊状动脉瘤破裂的因素之一.

参考文献/References:

1.Winn HR.Jane JA.Taylor J Prevalence of asymptomatic incidental aneurysms:review of 4568 arteriograms 2002
2.ISUIA Investigators Unruptured intracranial aneurysms-risk of rupture and risks of surgical intervention International Study of Unruptured Intracranial Aneurysma Investigators 1998
3.Suarez JI.Tarr RW.Selman WR Aneurysmal subarachnoid hemorrhage 2006
4.Foutrakis GN.Yonas H.Sclabassi RJ Saccular aneurysm formation in curved and bifurcating arteries 1999
5.Valencia A.Morales H.Rivers R Blood flow dynamics in patient-specific cerebral aneurysm models:the relationship between wall shear stress and aneurysm area index 2008
6.Raghavan ML.Ma B.Harbangh RE Quantified aneurysm shape and rupture risk 2005
7.Weir B.Amidei C.Kongable G The aspect ratio (dome/neck) of ruptured and unruptured aneurysms 2003
8.Malek AM.Alper SL.Izumo S Hemodynamie shear stress and its role in athereseleresis 1999
9.Shojima M.Oshima M.Takagi K Magnitude and role of wall shear stress on cerebral aneurysm:Computational fluid dynamic study of 20 middle cerebral artery aneurysms 2004
10.Ujiie H.Taehibana H.Hiramatsu O Effects of size and shape (aspect ratio) on the hemodynamies of saceular aneurysms:a possible index for surgical treatment of intracranial aneurysms 1999

备注/Memo

备注/Memo:
基金项目：国家自然科学基金，上海市科委科研计划资助项目
更新日期/Last Update: 2009-08-15