[1]钟 瑞,刘 锐,袁 康,等.血流介导的血管扩张与加压释放后桡动脉直径变化轨迹的研究[J].介入放射学杂志,2026,(06):646-650.[doi:10.3969/j.issn.1008-794X.2026.06.012 ]
　ZHONG Rui,LIU Rui,YUAN Kang,et al.The blood flow-mediated vasodilation and the trajectory of radial artery diameter changes after pressure release:a clinical study[J].J Intervent Med,2026,(06):646-650.[doi:10.3969/j.issn.1008-794X.2026.06.012 ]
点击复制

血流介导的血管扩张与加压释放后桡动脉直径变化轨迹的研究()

PDF下载中关闭

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2026年06
页码:
646-650
栏目:
临床研究
出版日期:
2026-06-17

文章信息/Info

Title:
The blood flow-mediated vasodilation and the trajectory of radial artery diameter changes after pressure release:a clinical study
文章编号:
1008-794X(2026)-006-0646-05
作者:
钟 瑞;  刘 锐;  袁 康;  高海琴;  陈恩典;  胡思娇;  樊新颖;  刘亚红;  郭亚辉
210002 江苏南京 东部战区总医院神经内科
Author(s):
ZHONG Rui; LIU Rui; YUAN Kang; GAO Haiqin; CHEN Endian; HU Sijiao; FAN Xinying; LIU Yahong; GUO Yahui.
Department of Neurology,Eastern Theater Command General Hospital,Nanjing,Jiangsu Province 210002,China
关键词:
血流介导的血管扩张;  加压;  释放;  桡动脉直径;  变化轨迹
分类号:
R651
DOI:
10.3969/j.issn.1008-794X.2026.06.012
文献标志码:
B
摘要:
目的 分析不同基线桡动脉直径患者应用血流介导的血管扩张(flow-mediated dilation,FMD)后桡动脉直径的时序变化轨迹,并初步探讨其对桡动脉穿刺的潜在影响。方法 采用前瞻性队列研究设计,连续纳入2024年1～7月拟行脑血管造影的113例患者,依据术前超声测量的基线桡动脉直径分为3组:1组(2.5～3.0 mm,n=35)、2组(<2.5 mm,n=54)、3组(>3.0 mm,n=24)。应用FMD技术(肱动脉加压至收缩压+30 mmHg,持续5 min阻断血流),于加压释放后即刻(舒张末期)、5、10、15 min通过超声测量桡动脉直径,分析其变化轨迹,同时记录穿刺次数、穿刺是否成功和鞘管置入时间,比较组间差异。结果 1组加压释放后的桡动脉直径变化呈现轻度减小、2组直径维持不变、3组直径变化呈现显著减小,3组首次穿刺成功率(1组85.7%、2组83.3%、3组87.5%)、平均穿刺次数(均为1.1次)及鞘管置入时间(约5.1 min)差异均无统计学意义(P>0.05)。结论 基线桡动脉直径<2.5 mm的患者在FMD后5 min内桡动脉直径稳定性较好,而较大直径血管则较早出现回缩趋势,FMD可导致不同基线桡动脉直径产生差异性的扩张后变化轨迹。

参考文献/References:

[1] 中国心血管健康联盟心血管病护理及技术培训中心专家委员会.经桡动脉介入诊疗患者术肢并发症预防及护理专家共识[J].介入放射学杂志,2024,33:465-471.
Expert Committee of Cardiovascular Care and Technical Training Center of China Cardiovascular Health Alliance; Nursing Professional Committee,China Branch of International Vascular Allianc.Expert consensus on prevention and nursing of surgical limb complications in patients undergoing transradial artery puncture intervention[J].J Interv Radiol,2024,33:465-471.
[2]Brunet MC,Chen SH,Peterson EC.Transradial access for neurointerventions:management of access challenges and complications[J].J Neurointerv Surg,2020,12:82-86.
[3]佘振垒,李婷婷,王小虎,等.经远端桡动脉路径行全脑血管造影术可行性分析[J].中国神经精神疾病杂志,2020,46:351-353.
She ZL,Li TT,Wang XH,et al.Feasibility analysis of total cerebral angiography via distal radial artery route[J].Chin J Nerv Ment Dis,2020,46:351-353.
[4]吴 剑,蔡然泽,齐 飚,等.经桡动脉入路行脑血管造影后发生早期桡动脉闭塞危险因素分析[J].中国神经精神疾病杂志,2024,50:332-336.
Wu J,Cai RZ,Qi B,et al.Incidence and predictors of early radial artery occlusion associated transradial approach[J].Chin J Nerv Ment Dis,2024,50:332-336.
[5]范光亮,孙 超,马永刚,等.桡动脉入路失败后转尺动脉入路在神经介入手术中的应用和可行性研究[J].介入放射学杂志,2025,34:614-619.
Fan GL,Sun C,Ma YG,et al.The use of transulnar approach after failure of transradial approach:its application in neurointerventional surgery and clinical feasibility[J].J Interv Radiol,2025,34:614-619.
[6]MikailiMirak S,Talasaz AH,Jenab Y,et al.Novel combined topical gel of lidocaine-verapamil-nitroglycerin can dilate the radial artery and reduce radial pain during trans-radial angioplasty[J].Int J Cardiol Heart Vasc,2021,32:100689.
[7]Beyer AT,Ng R,Singh A,et al.Topical nitroglycerin and lidocaine to dilate the radial artery prior to transradial cardiac catheterization:a randomized,placebo-controlled,double-blind clinical trial:the PRE-DILATE Study[J].Int J Cardiol,2013,168:2575-2578.
[8]Mullen MJ,Kharbanda RK,Cross J,et al.Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo:relevance to endothelial dysfunction in hypercholest-erolemia[J].Circ Res,2001,88:145-151.
[9]刘文武,张婷婷,俞旭华,等.血流介导的血管舒张评价潜水对血管内皮功能的影响[J].海军医学杂志,2025,46:521-524.
Liu WW,Zhang TT,Yu XH,et al.Evaluation of the effect of diving on vascular endothelial function by blood flow-mediated vasodilation[J].J Navy Med,2025,46:521-524.
[10]齐文升.长时阻塞血流介导的血管扩张在桡动脉穿刺中最佳穿刺时间点的研究[D].长春:吉林大学,2023.
Qi WS.Study on theoptimal puncture time point of long-duration occlusion flow-mediated vasodilation in radial artery puncture[D].Changchun:Jilin University,2023.
[11]Doubell J,Kyriakakis C,Weich H,et al.Radial artery dilatation to improve access and lower complications during coronary angiography:the RADIAL trial[J].Euro Inter-vention,2021,16:1349-1355.
[12]崔亚萌,王小飞.血流介导的血管扩张功能在临床中的应用[J].心血管病学进展,2015,36:458-461.
Cui YM,Wang XF.Clinical application of flow mediated vasodilation function[J].Adv Cardiovasc Dis,2015,36:458-461.
[13]钟 敏.血流介导的血管舒张功能检测2型糖尿病肱动脉内皮功能研究[J].吉林医学,2021,42:952-953.
Zhong M.Detection of blood flow-mediated vasodilation function study on endothelial function of brachial artery in type 2 diabetes mellitus[J].Jilin Med J,2021,42:952-953.
[14]Backman SB.Radial artery spasm:Should we worry?[J].Can J Anesth Can D'anesthésie,2017,64:1165-1168.
[15]潘文龙,王 芳,罗永春.经桡动脉路径行神经介入治疗患者的围术期护理研究进展[J].介入放射学杂志,2024,33:1142-1146.
Pan WL,Wang F,Luo YC.Research progress in perioperative nursing for patients undergoing neurointerventional therapy via radial artery access[J].J Interv Radiol,2024,33:1142-1146.
[16]Ying LH,Xu K,Gong XX,et al.Flow-mediated dilatation to relieve puncture-induced radial artery spasm:a pilot study[J].Cardiol J,2018,25:1-6.
[17]汤海燕,崔晓丽.桡动脉穿刺置管术中超声引导的临床应用[J].中国医药指南,2018,16:145-146.
Tang HY,Cui XL.Clinical application of ultrasound guidance in radial artery puncture and catheterization[J].Guide China Med,2018,16:145-146.
(收稿日期:2025-03-11)
(本文编辑:元 禾)

相似文献/References:

[1]尹劲东,邱静颐,李新,等.不孕症子宫输卵管加压造影140例体会[J].介入放射学杂志,1998,(01):49.

备注/Memo

备注/Memo:
基金项目: 科技创新研究计划项目(2023YYHLZX190)
通信作者: 郭亚辉 E-mail:1185626794@qq.com
更新日期/Last Update: 2026-05-25