[1]时 丰,范卫君,陈晓明.重视开展肝癌根治性消融治疗[J].介入放射学杂志,2026,(04):360-364.[doi:10.3969/j.issn.1008-794X.2026.04.003 ]
 SHI Feng,FAN Weijun,CHEN Xiaoming..Radical ablation therapy for hepatocellular carcinoma:a call for attention[J].J Intervent Med,2026,(04):360-364.[doi:10.3969/j.issn.1008-794X.2026.04.003 ]
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重视开展肝癌根治性消融治疗()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2026年04
页码:
360-364
栏目:
专论
出版日期:
2026-04-15

文章信息/Info

Title:
Radical ablation therapy for hepatocellular carcinoma:a call for attention
文章编号:
1008-794X(2026)-004-0360-05
作者:
时 丰 范卫君 陈晓明
510080 广东广州 南方医科大学附属广东省人民医院(广东省医学科学院)微创介入科(时 丰、陈晓明); 中山大学肿瘤防治中心(华南肿瘤学国家重点实验室/广东省癌症临床研究中心)微创介入科(范卫君)
Author(s):
SHI Feng1FAN Weijun2CHEN Xiaoming1.
1Department of Minimally Invasive Interventional Radiology,Affiliated Guangdong Provincial People's Hospital of Southern Medical University(Guangdong Academy of Medical Sciences),Guangzhou,Guangdong Province 510080,China;2Department of Minimally Invasive Interventional Radiology,Cancer Prevention and Treatment Center of Sun Yat-sen University(State Key Laboratory of Oncology in South China/Guangdong Provincial Cancer Clinical Research Center),Guangzhou,Guangdong Province 510080,China
关键词:
肝细胞癌 根治性消融 不完全消融 消融技术 肿瘤生物学
分类号:
R735.7
DOI:
10.3969/j.issn.1008-794X.2026.04.003
文献标志码:
A
摘要:
肝细胞癌(下称肝癌)局部消融治疗已从早期肝癌替代疗法发展成为与手术切除同等重要的一线根治性手段。实现“根治性消融”的核心目标是在影像引导下通过物理或化学方法,使消融区域完全覆盖肿瘤病灶并形成足够的“安全边界”(通常为5~10 mm),以达到肿瘤组织完全坏死。该文系统阐述了根治性消融定义,以射频、微波、冷冻消融为主的技术分类,并重点探讨了其合适的患者人群及关键考量因素,强调需综合评估肿瘤大小(尤其是≤3 cm者)、位置(如邻近血管、空腔脏器的危险部位)及侵袭性生物学特性(如微血管侵犯风险); 深入分析了导致不完全消融的技术和肿瘤因素及其通过富集肿瘤干细胞、诱导上皮-间质细胞转化、创建免疫抑制微环境等机制促进肿瘤复发的生物学基础; 综述了多模态影像融合导航、三维定量边界评估以及“非接触”消融等旨在提升根治性消融成功率的技术进展。该文呼吁介入医师高度重视根治性消融理念,通过规范化的患者选择、技术操作与疗效评估最终改善肝癌患者长期预后。

参考文献/References:

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(收稿日期:2025-12-09)
(本文编辑:谷 珂)

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金(82202271); 广州市基础与应用基础研究基金(2025A04J5522)
通信作者: 陈晓明 E-mail:cjr.chenxiaoming@vip.163.com
更新日期/Last Update: 2026-04-25