[1]艾正启,杨秀进,易 星,等.CT引导下放射性125I粒子植入治疗腹部难治性癌痛的疗效分析[J].介入放射学杂志,2025,34(11):1197-1203.[doi:10.3969/j.issn.1008-794X.2025.11.006]
 AI Zhengqi,YANG Xiujin,YI Xing,et al.Analysis of the therapeutic effect of CT-guided radioactive 125I seed implantation for the treatment of refractory abdominal cancerous pain[J].J Intervent Med,2025,34(11):1197-1203.[doi:10.3969/j.issn.1008-794X.2025.11.006]
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CT引导下放射性125I粒子植入治疗腹部难治性癌痛的疗效分析()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
34
期数:
2025年11
页码:
1197-1203
栏目:
非血管介入
出版日期:
2025-11-25

文章信息/Info

Title:
Analysis of the therapeutic effect of CT-guided radioactive 125I seed implantation for the treatment of refractory abdominal cancerous pain
文章编号:
1008-794X(2025)-011-1197-07
作者:
艾正启 杨秀进 易 星 石荣书 赵开飞
563000 贵州遵义 遵义医科大学附属医院放射科
Author(s):
AI ZhengqiYANG XiujinYI XingSHI RongshuZHAO Kaifei.
Department of Radiology,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province 563000,China
关键词:
难治性癌痛 腹腔神经丛阻滞 125I粒子植入 疼痛缓解 病例对照研究
分类号:
R735
DOI:
10.3969/j.issn.1008-794X.2025.11.006
文献标志码:
A
摘要:
目的 探讨CT引导下放射性125I粒子植入(ISI)腹腔神经丛阻滞治疗腹部难治性癌痛的疗效及安全性。方法 回顾性分析60例腹部恶性肿瘤引起的难治性癌痛患者(VAS评分≥4分)的资料。A组(n=29)采用无水乙醇治疗,B组(n=31)采用ISI。主要研究终点为疼痛评分(visual analogue scale,VAS)、每日吗啡消耗量(daily morphine consumption,DMC)和局部肿瘤控制率(local tumor control,LTC)。次要终点为手术成功率及术后相关并发症。结果 A、B两组的手术成功率均为100%,术后均未发生严重并发症,两组患者术后1~8周疼痛VAS评分均持续下降,差异无统计学意义; A组VAS评分在术后第8~12周(T8~T12)时升高(P<0.01)。B组疼痛缓解时间持续到T16~T24周才出现升高。T8时B组LTC率优于A组,差异有统计学意义(P<0.01)。结论 ISI腹腔神经丛阻滞能有效缓解腹部肿瘤引起的难治性癌痛,与无水乙醇相比ISI维持时间更持久(长达T16~T24周),且能有效控制局部肿瘤的生长,值得临床推广运用。

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(收稿日期:2025-02-19)
(本文编辑:茹 实)

备注/Memo

备注/Memo:
通信作者: 赵开飞 E-mail:zhaokaifei8943@sina.com
更新日期/Last Update: 2025-11-25