[1]陈海波,万云云,管清龙,等.经导管接触碎栓、溶栓治疗急性肺动脉栓塞的疗效[J].介入放射学杂志,2025,34(03):307-310.
 CHEN Haibo,WAN Yunyun,GUAN Qinglong,et al.The clinical efficacy of catheter-directed breaking thrombus together with thrombolysis in the treatment of acute pulmonary embolism[J].journal interventional radiology,2025,34(03):307-310.
点击复制

经导管接触碎栓、溶栓治疗急性肺动脉栓塞的疗效()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
34
期数:
2025年03
页码:
307-310
栏目:
临床研究
出版日期:
2025-03-25

文章信息/Info

Title:
The clinical efficacy of catheter-directed breaking thrombus together with thrombolysis in the treatment of acute pulmonary embolism
作者:
陈海波万云云管清龙王开东刘成龙李同飞
Author(s):
CHEN HaiboWAN YunyunGUAN QinglongWANG KaidongLIU ChenglongLI Tongfei.
Department of Interventional Radiology,Second Affiliated Hospital of Shandong First Medical University,Tai′an,Shandong Province 271000,China
关键词:
【关键词】经导管碎栓经导管溶栓急性肺动脉栓塞。
文献标志码:
A
摘要:
【摘要】目的探讨经导管接触溶栓(CDT)治疗急性肺动脉栓塞的临床疗效。方法对山东第一医科大学第二附属医院215例急性肺栓塞的患者行肺动脉造影术,明确血栓部位后通过旋转猪尾巴导管碎栓和局部灌注溶栓药物尿激酶来开通肺动脉。比较患者CDT前后的临床症状、血氧饱和度、肺动脉压力、BNP、D-二聚体、RV/LV横径比值。通过PESI评分评价肺栓塞严重程度,PESI分级3和PESI分级4属于中危组,PESI分级5属于高危组。结果术后症状即刻缓解210例,完全开通200例,部分开通15例。术前肺动脉压、血氧饱和度、BNP、D-二聚体、RV/LV横径比值分别为(46.24±5.32) mmHg、(90.36±3.23)%、(8 000.12±750.56) pg/mL、(7.5±2.3) mg/L、1.63±0.22;术后1周分别为(26.12±3.36) mmHg 、(98.74±2.12)%、(240.35±33.52) pg/mL、(1.75±0.36) mg/L、1.11±0.13,与治疗前比较差异均有统计学意义(均P<0.05)。患者术前有咯血、休克及晕厥症状,在CDT术后1周均消失,而呼吸困难、胸痛及心悸症状和各项体征在CDT术后均明显减轻,差异有统计学意义(均P<0.05)。不同PESI分级的患者生存时间比较差异有统计学意义(P<0.05)。术后无严重心律失常、脑出血、消化道出血等并发症;术后3个月行肺动脉增强CT检查肺动脉主干显影良好,无血栓充盈缺损影。结论CDT治疗急性肺栓塞时能够及时快速开通阻塞的肺动脉,恢复肺动脉的血流动力学,纠正低氧血症,是一种安全、有效、快速的方法。

参考文献/References:

[1]夏风飞,孙振棣,王新安,等.两种肺动脉压测量方法在急性中高危肺栓塞介入治疗中的临床价值对比研究[J].介入放射学杂志,2021,30:657-661.
[2]Hepburn-Brown M,Darvall J,Hammerschlag G.Acute pulmonary embolism:a concise review of diagnosis and management[J].Intern Med J,2019,49:15-27.
[3]李博.急性肺血栓栓塞症的临床特征,预后评估和介入诊疗研究[D].长春:吉林大学,2024.
[4]Konstantinides SV,Meyer G,Becattini C,et al.2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS)[J].Eur Heart J,2020,41:543-603.
[5]Chan CM,Woods C,Shorr AF.The validation and reproducibility of the pulmonary embolism severity index[J].J Thromb Haemost,2010,8:1509-1514.
[6]方铭,吴炳祥.浅谈急性肺栓塞的介入治疗[J].中国介入心脏病学杂志,2021,29:291-294.
[7]Greenfield LJ,Proctor MC,Williams DM,et al.Long-term experience with transvenous catheter pulmonary embolectomy[J].J Vasc Surg,1993,18:450-457.
[8]孙仁华.介入溶栓球囊扩张术治疗肺动脉栓塞疗效探讨[J].介入放射学杂志,2009,18:19-21.
[9]陈玉成,曾智.肺动脉支架应用现状和进展[J].心血管病学进展,2010,31:645-648.
[10]Jia J,Han X.Low dose urokinase thrombolytic therapy for intermediate risk acute pulmonary thromboembolism[J].Clinical Focus,2015,30:1251-1253.
[11]Pinheiro G,Alves AM,Rodrigues Neves I,et al.Left lung and pulmonary artery hypoplasia:a rare case of hemoptysis[J].Eur J Case Rep Intern Med,2020,7:001490.
[12]张学彬,吕维富,孙一兵,等.经皮介入碎栓及溶栓治疗大面积肺栓塞[J].介入放射学杂志,2005,14:39-42.
[13]Sakai K,Minoura Y,Matsui T,et al.Primary pulmonary artery intimal sarcoma case with elevated coagulation markers[J].J Clin Diagn Res,2017,11:OD10-OD11.

备注/Memo

备注/Memo:
(收稿日期:2024-03-12)
(本文编辑:新宇)
更新日期/Last Update: 2025-03-25