[1]朱晓阳,邵国良.钇90微球在结直肠癌肝转移治疗中的应用[J].介入放射学杂志,2025,34(01):115-120.
 ZHU Xiaoyang,SHAO Guoliang..Clinical application of yttrium-90 microspheres in the treatment of hepatic metastases from colorectal cancer [J].journal interventional radiology,2025,34(01):115-120.
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钇90微球在结直肠癌肝转移治疗中的应用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
34
期数:
2025年01
页码:
115-120
栏目:
综述
出版日期:
2025-01-22

文章信息/Info

Title:
Clinical application of yttrium-90 microspheres in the treatment of hepatic metastases from colorectal cancer
作者:
朱晓阳邵国良
Author(s):
ZHU XiaoyangSHAO Guoliang.
Second College of Clinical Medicine,Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang Province 310053,China
关键词:
【关键词】钇90微球结直肠癌肝转移选择性内放疗
文献标志码:
A
摘要:
【摘要】肝脏是结直肠癌最常见的转移部位,治疗相对困难。目前钇90微球选择性内放疗(selective internal radiotherapy,SIRT)治疗结直肠癌肝转移(colorectal cancer liver metastasis,CRLM)在国内已进入临床应用。这种新型内放射治疗虽有其技术难点,但与传统治疗相比也具有独特优势。其可有效控制肿瘤进展,并为暂时无法手术切除肿瘤患者增加未来残余肝体积(future liver remnant,FLR),从而达到R0切除或理想的放射消融创造条件。其联合一、二线化疗可改善肝转移瘤局部区域反应,为患者提供化疗间期。对于化疗失败且肿瘤不可切除患者,SIRT可更好地控制肿瘤进展、延长患者生存期。未来联合靶向治疗和免疫治疗也有广阔的发展前景。该文主要就钇90微球及其在CRLM中的应用和进展作一综述。

参考文献/References:

[1]Siegel RL,Miller KD,Sauer A,et al.Colorectal cancer statistics,2020[J].CA Cancer J Clin,2020,70:145-164.
[2]牛惠敏,王志恒,高石鑫,等.钇90放射性微球在肝脏恶性肿瘤中的应用及进展[J].肝癌电子杂志,2021,8:36-40.
[3]郑致远.钇90放射性微球治疗肝脏恶性肿瘤的应用进展[J].复旦学报(医学版),2020,47:622-627.
[4]高洁,刘晓明,周文华,等.90Y微球的研发现状与应用研究[J].同位素,2022,35:189-199.
[5]Levillain H,Bagni O,Deroose CM,et al.International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres[J].Eur J Nucl Med Mol Imaging,2021,48:1570-1584.
[6]Salem R,Gordon AC,Mouli S,et al.Y90 radioembolization significantly prolongs time to progression compared with chemoembolization in patients with hepatocellular carcinoma[J].Gastroenterology,2016,151:1155-1163.e2.
[7]Moslim MA,Jeyarajah DR.Narrative review of the role of yttrium-90 selective internal radiation therapy in the surgical management of colorectal liver metastases[J].J Gastrointest Oncol,2021,12:2438-2446.
[8]Gray B,Van HG,Hope M,et al.Randomised trial of SIR-spheres plus chemotherapy vs chemotherapy alone for treating patients with liver metastases from primary large bowel cancer[J].Ann Oncol,2001,12:1711-1720.
[9]Bargellini I,Bozzi E,Lorenzoni G,et al.Role of transhepatic arterial radioembolization in metastatic colorectal cancer[J].Cardiovasc Intervent Radiol,2022,45:1579-1589.
[10]Memeo R,Conticchio M,Deshayes E,et al.Optimization of the future remnant liver:review of the current strategies in Europe[J].Hepatobiliary Surg Nutr,2021,10:350-363.
[11]Garlipp B,Gibbs P,Van Hazel GA,et al.Secondary technical resectability of colorectal cancer liver metastases after chemotherapy with or without selective internal radiotherapy in the randomized SIRFLOX trial[J].Br J Surg,2019,106:1837-1846.
[12]Birgin E,Rasbach E,Seyfried S,et al.Contralateral liver hypertrophy and oncological outcome following radioembolization with 90Y-Microspheres:a systematic review[J].Cancers (Basel),2020,12:294.
[13]Ironside N,Bell R,Bartlett A,et al.Systematic review of perioperative and survival outcomes of liver resections with and without preoperative portal vein embolization for colorectal metastases[J].HPB (Oxford),2017,19:559-566.
[14]王草叶,贾中芝,王维平.钇-90微球放射性肝段切除——钇-90微球放射栓塞系列回顾(九)[J].介入放射学杂志,2018,27:1210-1216.
[15]Entezari P,Gabr A,Salem R,et al.Yttrium-90 for colorectal liver metastasis-the promising role of radiation segmentectomy as an alternative local cure[J].Int J Hyperthermia,2022,39:620-626.
[16]Kurilova I,Bendet A,Fung EK,et al.Radiation segmentectomy of hepatic metastases with Y-90 glass microspheres[J].Abdom Radiol (NY),2021,46:3428-3436.
[17]Wasan HS,Gibbs P,Sharma NK,et al.First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE,SIRFLOX,and FOXFIRE-Global):a combined analysis of three multicentre,randomised,phase Ⅲ trials[J].Lancet Oncol,2017,18:1159-1171.
[18]Gibbs P,Heinemann V,Sharma NK,et al.Effect of primary tumor side on survival outcomes in untreated patients with metastatic colorectal cancer when selective internal radiation therapy is added to chemotherapy:combined analysis of two randomized controlled studies[J].Clin Colorectal Cancer,2018,17:e617-e629.
[19]Van Cutsem E,Cervantes A,Adam R,et al.ESMO consensus guidelines for the management of patients with metastatic colorectal cancer[J].Ann Oncol,2016,27:1386-1422.
[20]Mulcahy MF,Mahvash A,Pracht M,et al.Radioembolization with chemotherapy for colorectal liver metastases:a randomized,open-label,international,multicenter,phase Ⅲ trial[J].J Clin Oncol,2021,39:3897-3907.
[21]Hendlisz A,Van den Eynde M,Peeters M,et al.Phase Ⅲ trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy[J].J Clin Oncol,2010,28:3687-3694.
[22]Benson AB,Venook AP,Al-Hawary MM,et al.Colon cancer,version 2.2021,NCCN clinical practice guidelines in oncology[J].J Natl Compr Canc Netw,2021,19:329-359.
[23]Helmberger T,Golfieri R,Pech M,et al.On behalf of the CIRT steering committee;On behalf of the CIRT principal investigators.Clinical application of trans-arterial radioembolization in hepatic malignancies in Europe:first results from the prospective multicentre observational study CIRSE registry for SIR-spheres therapy (CIRT)[J].Cardiovasc Intervent Radiol,2021,44:21-35.
[24]Sofocleous CT,Garcia AR,Pandit-Taskar N,et al.Phase Ⅰ trial of selective internal radiation therapy for chemorefractory colorectal cancer liver metastases progressing after hepatic arterial pump and systemic chemotherapy[J].Clin Colorectal Cancer,2014,13:27-36.
[25]Walter T,Hawkins NS,Pollock RF,et al.Systematic review and network meta-analyses of third-line treatments for metastatic colorectal cancer[J].J Cancer Res Clin Oncol,2020,146:2575-2587.
[26]Kemeny NE,Melendez FD,Capanu M,et al.Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma[J].J Clin Oncol,2009,27:3465-3471.
[27]Cercek A,Gendel V,Jabbour S,et al.A comparison of yttrium-90 microsphere radioembolization to hepatic arterial infusional chemotherapy for patients with chemo-refractory hepatic colorectal metastases[J].Curr Treat Options Oncol,2017,18:42.
[28]Filippi L,Evangelista L,Schillaci O.Integrated use of 90Y-labeled microspheres and immune checkpoint inhibitors in hepatic tumors:current status and future directions[J].Expert Rev Gastroenterol Hepatol,2023,17:531-538.
[29]Wang C,Park J,Ouyang C,et al.A pilot feasibility study of yttrium-90 liver radioembolization followed by durvalumab and tremelimumab in patients with microsatellite stable colorectal cancer liver metastases[J].Oncologist,2020,25:382-e776.


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备注/Memo

备注/Memo:
(收稿日期:2024-01-29)
(本文编辑:谷珂)
更新日期/Last Update: 2025-01-22