[1]韩廷超,王忠,申梦圆.载药微球对比碘化油肝动脉化疗栓塞联合局部热消融治疗巨块型肝癌的疗效分析[J].介入放射学杂志,2024,33(09):989-994.
HAN Tingchao,WANG Zhong,SHEN Mengyuan..Drug-eluting bead TACE versus iodized oil TACE combined with local thermal ablation for the treatment of massive hepatocellular carcinoma[J].journal interventional radiology,2024,33(09):989-994.
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载药微球对比碘化油肝动脉化疗栓塞联合局部热消融治疗巨块型肝癌的疗效分析()
《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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33
- 期数:
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2024年09
- 页码:
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989-994
- 栏目:
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临床研究
- 出版日期:
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2024-09-17
文章信息/Info
- Title:
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Drug-eluting bead TACE versus iodized oil TACE combined with local thermal ablation for the treatment of massive hepatocellular carcinoma
- 作者:
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韩廷超; 王忠; 申梦圆
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- Author(s):
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HAN Tingchao; WANG Zhong; SHEN Mengyuan.
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Department of Radiology,Nanyang Municipal First People′s Hospital,Nanyang,Henan Province 473000,China
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- 关键词:
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【关键词】载药微球; 局部热消融; 肝动脉化疗栓塞; 巨块型肝癌; 临床疗效; 安全性; 生存分析
- 文献标志码:
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A
- 摘要:
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【摘要】目的对比碘化油肝动脉化疗栓塞(C-TACE)与载药微球肝动脉化疗栓塞(D-TACE)联合局部热消融治疗巨块型肝癌的疗效。方法选择2018年4月至2021年6月在南阳市第一人民医院就诊的巨块型肝癌患者72例,以随机数字表法分为研究组36例,对照组36例。对照组采用局部热消融联合C-TACE治疗,研究组采用局部热消融联合D-TACE治疗。对比2组临床疗效、肿瘤标志物、肝功能、血清学指标、血流灌注指标、不良反应,术后随访2年,对比2组无进展生存期(PFS)。结果研究组疾病控制率(DCR)、客观缓解率(ORR)比对照组高(P<0.05)。术后3个月,2组甲胎蛋白(AFP)、异常凝血酶原(PIVKA-Ⅱ)水平均降低(P<0.05),且研究组更低;2组丙氨酸转氨酶(ALT)均升高(P<0.05),而研究组低于对照组;2组白蛋白(ALB)均降低(P<0.05),而研究组高于对照组(P<0.05);2组表皮生长因子受体(EGFR)、血管内皮生长因子(VEGF)、胸腺激酶1(TK1)水平均降低(P<0.05),且研究组更低;2组血容量(BV)、血流量(BF)均降低(P<0.05),且研究组更低;2组对比剂平均通过时间(MTT)均升高(P<0.05),且研究组更高。研究组不良反应总发生率比对照组低(P<0.05)。术后随访2年,2组各失访1例,随访率为97.22%,研究组中位PFS为15.41个月(95%CI:7.02~23.19),对照组中位PFS为12.34个月(95%CI:6.16~22.30),研究组PFS曲线优于对照组(P<0.05)。结论局部热消融联合D-TACE可改善巨块型肝癌患者肝功能、血流灌注情况,疗效显著,降低肿瘤标志物,调节血清EGFR、VEGF、TK1表达,安全可靠,且可延长中位PFS。
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备注/Memo
- 备注/Memo:
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(收稿日期:2023-09-18)
(本文编辑:新宇)
更新日期/Last Update:
2024-09-15