[1]隰子涵,杨永波,邵国良.MRI和临床危险因素对中晚期肝细胞癌首次D-TACE近期疗效预测价值分析[J].介入放射学杂志,2024,33(04):376-381.
　XI Zihan,YANG Yongbo,SHAO Guoliang..The value of MRI and clinical risk factors in predicting the short-term efficacy of initial D-TACE in patients with intermediate and advanced stage hepatocellular carcinoma[J].journal interventional radiology,2024,33(04):376-381.
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MRI和临床危险因素对中晚期肝细胞癌首次D-TACE近期疗效预测价值分析()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
33
期数:
2024年04
页码:
376-381
栏目:
肿瘤介入
出版日期:
2024-05-04

文章信息/Info

Title:
The value of MRI and clinical risk factors in predicting the short-term efficacy of initial D-TACE in patients with intermediate and advanced stage hepatocellular carcinoma
作者:
隰子涵;  杨永波;  邵国良
Author(s):
XI Zihan;  YANG Yongbo;  SHAO Guoliang.
Department of Radiology， Zhejiang Provincial Cancer Hospital， Hangzhou， Zhejiang Province 310005， China
关键词:
【关键词】 肝细胞癌;  药物洗脱微球;  经导管动脉化疗栓塞术;  多参数磁共振成像;  无疾病进展期
文献标志码:
A
摘要:
【摘要】 目的 探讨肝细胞癌（HCC）患者术前增强MRI影像学特征及相关临床资料与首次药物洗脱微球- 经导管动脉化疗栓塞术（D- TACE）近期疗效的关系。方法 回顾性分析113例中晚期HCC患者临床及MRI影像学资料。依据近期疗效分为客观缓解（OR）组（n=74）和非OR组（n=39）。采用单因素及多因素logistic回归分析筛选出与D- TACE近期疗效相关的独立因素。采用Kaplan- Meier法计算无疾病进展期（PFS），Log- rank检验反映近期疗效与PFS关系。通过Cox比例风险回归确定与PFS相关影响因素。结果 多因素logistic回归分析结果显示，前白蛋白低（OR=1.012，P=0.029）、载药量多（OR=0.969，P=0.016）、肿瘤/肝脏体积比高（OR=0.001，P=0.007）、肿瘤边缘强化程度重（OR=0.239，P=0.049）与首次D- TACE近期疗效显著相关。OR组、非OR组中位PFS分别为8.5个月、4.5个月，OR组预后更佳（χ2=4.903，P=0.027）。Cox比例风险回归分析显示首次D- TACE近期疗效好、肿瘤最大径大、肿瘤/肝脏体积比小是PFS保护因素。结论 HCC患者肿瘤/肝脏体积比低、前白蛋白高、载药量少、肿瘤边缘强化程度轻，首次D- TACE近期疗效更可能达到OR，PFS更长。

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备注/Memo

备注/Memo:
（收稿日期：2023- 08- 01）
（本文编辑：谷 珂）
更新日期/Last Update: 2024-05-04