[1]钱超一,郝伟远,邵国良,等.桡动脉途径对肝癌患者行亚叶酸/5-氟尿嘧啶/奥沙利铂肝动脉持续灌注化疗的临床应用[J].介入放射学杂志,2023,32(05):474-477.
　QIAN Chaoyi,HAO Weiyuan,SHAO Guoliang,et al.Clinical application of hepatic arterial infusion chemotherapy via radial artery access by using FOLFOX scheme in treating patients with liver cancer[J].journal interventional radiology,2023,32(05):474-477.
点击复制

桡动脉途径对肝癌患者行亚叶酸/5-氟尿嘧啶/奥沙利铂肝动脉持续灌注化疗的临床应用()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年05
页码:
474-477
栏目:
临床研究
出版日期:
2023-05-30

文章信息/Info

Title:
Clinical application of hepatic arterial infusion chemotherapy via radial artery access by using FOLFOX scheme in treating patients with liver cancer
作者:
钱超一;  郝伟远;  邵国良;  郑家平
Author(s):
QIAN Chaoyi;  HAO Weiyuan;  SHAO Guoliang;  ZHENG Jiaping.
Department of Interventional Therapy， Zhejiang Provincial Cancer Hospital， Hangzhou， Zhejiang Province 310022， China
关键词:
【关键词】 肝恶性肿瘤;  桡动脉;  FOLFOX方案;  肝动脉灌注化疗
文献标志码:
A
摘要:
【摘要】 目的 探讨经桡动脉（radial artery， RA）途径行亚叶酸/5- 氟尿嘧啶/奥沙利铂（folinic acid/5- fluorouracil/oxaliplatin， FOLFOX）- 肝动脉持续灌注化疗（hepatic artery infusion chemotherapy， HAIC）的可行性及安全性。方法 回顾性分析行2周期FOLFOX- HAIC治疗的肝癌患者140例，其中经桡动脉途径60例，经股动脉（femoral artery， FA）途径80例。观察并记录两组患者的手术时间及辐射剂量，穿刺和手术成功率，术中、术后并发症发生情况。结果 RA组60例患者中，52（86.67%）例成功置管化疗，FA组80例（100%）均成功置管化疗，差异有统计学意义（P＜0.05）。在手术时间和患者所受辐射剂量方面，RA组高于FA组（P＜0.05）。RA组和FA组术后并发症发生率为19.23%和20.00%，差异无统计学意义（P＞0.05）。RA组患者在HAIC过程中也可下床活动。结论 采用经RA途径行FOLFOX- HAIC术安全、可行，患者舒适性明显提高，但在手术难度、手术操作时长及辐射剂量方面存在一定的不足。

参考文献/References:

［1］ Lewandowski RJ，Geschwind JF，Liapi E，et al. Transcatheter intraarterial therapies：rationale and overview［J］. Radiology， 2011， 259： 641- 657.
［2］ Kondo M，Morimoto M，Kobayashi S et al. Randomized， phase Ⅱ trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced hepatocellular carcinoma： SCOOP-2 trial［J］. BMC Cancer， 2019， 19：954.
［3］ Li QJ，He MK，Chen HW，et al. Hepatic arterial infusion of oxaliplatin，fluorouracil，and leucovorin versus transarterial chem-oembolization for large hepatocellular carcinoma： a randomized phase Ⅲ trial［J］. J Clin Oncol， 2022， 40： 150-160.
［4］ He M，Li Q，Zou R，et al. Sorafenib plus hepatic arterial infusion of oxaliplatin， fluorouracil， and leucovorin vs sorafenib alone for hepatocellular carcinoma with portal vein invasion： a randomized clinical trial［J］. JAMA Oncol， 2019， 5：953-960.
［5］ Zhao X，Sun X，Jing J et al. Safety study of Folfox-HAIC in relieving bed restriction［J］. J Interv Med， 2021， 4： 203-207.
［6］ Plourde G，Pancholy SB，Nolan J，et al. Radiation exposure in relation to the arterial access site used for diagnostic coronary angiography and percutaneous coronary intervention： a systematic review and meta-analysis［J］. Lancet， 2015， 386： 2192-2203.
［7］ Anjum I，Khan M，Aadil M，et al. Transradial vs. transfemoral approach in cardiac catheterization：a literature review［J］. Cureus， 2017， 9： e1309.
［8］ Shah B，Bangalore S，Feit F，et al. Radiation exposure during coronary angiography via transradial or transfemoral approaches when performed by experienced operators［J］. Am Heart J， 2013， 165： 286-292.
［9］ 胡晓钢，杨晓仙，郭晓华，等． 经桡动脉途径前列腺动脉栓塞术可行性及安全性研究［J］． 介入放射学杂志， 2017， 26：399-402．
［10］ 张秩源，王 勇，徐 浩，等． 经桡动脉及股动脉入路对肝癌患者行TACE的前瞻性研究［J］． 医学影像学杂志， 2022， 32：254-258．
［11］ Ghosh A，Gupta V，Al Khalifah A，et al. Transradial versus trans-femoral arterial access in DEB-TACE for hepatocellular carcinoma［J］. J Clin Imaging Sci， 2022， 12： 38.
［12］ 卜国森，刘志强，何鹏义，等． 经桡动脉与经股动脉途径介入治疗ST段抬高心肌梗死疗效及安全性的Meta分析［J］． 中国循证心血管医学杂志， 2015， 7：170-175， 187．
［13］ Ratib K，Mamas MA，Routledge HC，et al. Influence of access site choice on incidence of neurologic complications after percutaneous coronary intervention［J］. Am Heart J， 2013， 165：317-324.
［14］ Kanei Y，Kwan T，Nakra NC，et al. Transradial cardiac catheteri-zation：a review of access site complications［J］. Catheter Cardiovasc Interv， 2011， 78： 840-846.
［15］ 刘小方，李国庆，程 慧，等． 重复经桡动脉途径冠状动脉介入术后桡动脉狭窄或闭塞的相关危险因素分析［J］. 医学综述，2020， 26： 5.

相似文献/References:

[1]钟 华,方志敏. Ａｌｌｅｎ试验异常患者经桡动脉冠脉介入诊治的血管并发症[J].介入放射学杂志,2012,(05):366.
　. Ｔｈｅ ｖａｓｃｕｌａｒ ｃｏｍｐｌｉｃａｔｉｏｎｓ ｏｆ ｔｒａｎｓｒａｄｉａｌ ｃｏｒｏｎａｒｙ ａｎｇｉｏｇｒａｐｈｙ ａｎｄ ｉｎｔｅｒｖｅｎｔｉｏｎ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ａｂｎｏｒｍａｌ Ａｌｌｅｎ ｔｅｓｔ[J].journal interventional radiology,2012,(05):366.
[2]黄春燕,王中洁,陈丽媛.经桡动脉冠状动脉造影套管针与裸针穿刺并发症的对比研究[J].介入放射学杂志,2010,(11):905.
　HUANG Chun-yan,WANG Zhong-jie,CHEN Li-yuan.Complications of transradial coronary angiography: a comparative study between using trocar needle and using bare needle[J].journal interventional radiology,2010,(05):905.
[3]钟继明,李 浪,陆永光,等.经桡动脉冠心病介入诊疗中桡动脉痉挛的发生及其预测因素[J].介入放射学杂志,2011,(04):265.
　ZHONG Ji-ming,LI Lang,LU Yong-guang,et al.Radial artery spasm occurred in transradial coronary intervention for coronary heart disease its occurrence and predictors[J].journal interventional radiology,2011,(05):265.
[4]黄志志,梁 柯. 经桡动脉路径椎动脉支架成形术的临床研究[J].介入放射学杂志,2012,(01):14.
　HUANG Zhi-zhi,LIANG Ke..Vertebral artery stenting via radial artery access: a clinical study [J].journal interventional radiology,2012,(05):14.
[5]胡文志,杨季明. 联合地尔硫和硝酸甘油防治桡动脉痉挛的有效性和安全性观察[J].介入放射学杂志,2014,(06):474.
　HU Wen- zhi,YANG Ji- ming.. Combination use of diltiazem and nitroglycerin in preventing radial artery spasm in performing coronary angiography： observation of its efficacy and safety[J].journal interventional radiology,2014,(05):474.
[6]陈建宁,胡文志.无鞘 7 F普通导引导管经桡动脉介入治疗冠状动脉病变临床效果[J].介入放射学杂志,2017,(04):296.
　CHENG Jianning,HU Wenzhi.Transradial interventional treatment of coronary artery lesions by using sheathless common 7- F guiding catheter： its clinical efficacy[J].journal interventional radiology,2017,(05):296.
[7]杨海华,周晓梅,刘立斌.长导丝交换技术在经桡动脉途径脑血管造影术中的应用 [J].介入放射学杂志,2017,(08):676.
　YANG Haihua,ZHOU Xiaomei,LIU Libin.Application of long guidewire exchange technique in cerebral angiography via radial artery access [J].journal interventional radiology,2017,(05):676.
[8]唐文栋,许旭东,白 元,等.桡动脉入路室间隔缺损封堵术初步临床应用 [J].介入放射学杂志,2018,27(02):114.
　TANG Wendong,XU Xudong,BAI Yuan,et al.Preliminary clinical application of transcatheter closure of ventricular septal defect via radial approach China[J].journal interventional radiology,2018,27(05):114.
[9]周 慷,魏梦蝶,石海峰,等.术中增强CT及全身麻醉下呼吸控制在特殊部位肝肿瘤射频消融中的应用 [J].介入放射学杂志,2018,27(09):860.
　ZHOU Kang,WEI Mongdie,SHI Haifeng,et al.The application of intraoperative enhanced CT scan and respiratory control under general anesthesia in radiofrequency ablation treatment of hepatic malignant tumors located at special regions[J].journal interventional radiology,2018,27(05):860.
[10]沈正林,秦永芳.左侧桡动脉头静脉内瘘术后手背肿胀1例 [J].介入放射学杂志,2019,28(04):399.
　SHEN Zhenglin,QIN Yongfang..Successful management of the swelling of the back of hand occurring after anastomosis of internal fistula between left radial artery and cephalic vein： report of one case[J].journal interventional radiology,2019,28(05):399.

备注/Memo

备注/Memo:
（收稿日期：2022- 06- 07）
（本文编辑：新 宇）
更新日期/Last Update: 2023-05-30