[1]王海军,仰望骄.介入溶栓与静脉溶栓治疗肺栓塞有效性和安全性Meta分析 [J].介入放射学杂志,2023,32(02):173-176.
　WANG Haijun,YANG Wangjiao..Interventional thrombolysis versus intravenous thrombolysis for the treatment of pulmonary embolism: a meta-analysis of efficacy and safety[J].journal interventional radiology,2023,32(02):173-176.
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介入溶栓与静脉溶栓治疗肺栓塞有效性和安全性Meta分析


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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年02
页码:
173-176
栏目:
临床研究
出版日期:
2023-03-03

文章信息/Info

Title:
Interventional thrombolysis versus intravenous thrombolysis for the treatment of pulmonary embolism: a meta-analysis of efficacy and safety
作者:
王海军; 　仰望骄
Author(s):
WANG Haijun;  YANG Wangjiao.
Department of Respiratory Medicine, Dongyang People’s Hospital, Jinhua, Zhejiang Province 322100, China
关键词:
【关键词】 肺栓塞; 溶栓; 介入治疗; Meta分析
文献标志码:
A
摘要:
【摘要】 目的　采用Meta分析对比介入溶栓与静脉溶栓治疗肺栓塞的效果和安全性。方法　检索数据库PubMed、Embase、Web of Science、Cochrane Library、Clinical Trials，中国知网、维普、万方及中国生物医学文献服务系统（SinoMed）中对比介入溶栓与静脉溶栓治疗肺栓塞效果和安全性的相关文献，检索日期为建库至2021年8月。根据纳入和排除标准筛选文献。采用 RevMan 5.3和Stata 14.0软件分析介入溶栓与静脉溶栓治疗肺栓塞住院期间病死率、颅内出血发生率及大出血发生率比值比（OR）和95%CI，并对文献发表偏倚进行分析。结果　共有7篇文献66 267例肺栓塞患者纳入研究。其中12 269例接受介入溶栓治疗（介入溶栓组），53 998例接受静脉溶栓治疗（静脉溶栓组）。Meta分析结果显示，介入溶栓组患者住院期间病死率［OR=0.35，95%CI（0.28，0.43），P＜0.01］、颅内出血发生率［OR=0.62，95%CI（0.45，0.85），P=0.003］低于静脉溶栓组，差异均有统计学意义；大出血发生率低于静脉溶栓组，但差异无统计学意义［OR=0.74，95%CI（0.50，1.11），P=0.15］。对住院期间病死率进行发表偏倚分析，漏斗图显示两侧基本对称，Egger检验提示文献存在发表偏倚可能性小（P=0.627）。结论　介入溶栓治疗肺栓塞效果和安全性优于静脉溶栓，住院期间病死率和颅内出血发生率较低。

参考文献/References:

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备注/Memo

备注/Memo:
（收稿日期：2021-12-31）
（本文编辑：边　佶）
更新日期/Last Update: 2023-03-03