[1]吉思璇,吴 迪,白曼莫.动脉瘤性蛛网膜下腔出血患者外周血单个核细胞中瞬时受体电位通道M2水平与介入治疗预后的关系[J].介入放射学杂志,2022,31(07):655-659.
 JI Sixuan,WU Di,BAI Manmo..Correlation between transient receptor potential melastatin 2 in peripheral blood mononuclear cells and the prognosis of interventional treatment in patients with aneurysmal subarachnoid hemorrhage [J].journal interventional radiology,2022,31(07):655-659.
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动脉瘤性蛛网膜下腔出血患者外周血单个核细胞中瞬时受体电位通道M2水平与介入治疗预后的关系()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
31
期数:
2022年07
页码:
655-659
栏目:
神经介入
出版日期:
2022-09-03

文章信息/Info

Title:
Correlation between transient receptor potential melastatin 2 in peripheral blood mononuclear cells and the prognosis of interventional treatment in patients with aneurysmal subarachnoid hemorrhage
作者:
吉思璇 吴 迪 白曼莫
Author(s):
JI Sixuan WU Di BAI Manmo.
Department of Medical Imaging, Sanya Municipal Hospital of Traditional Chinese Medicine, Sanya, Hainan Province 572000, China
关键词:
【关键词】 动脉瘤性蛛网膜下腔出血 外周血单个核细胞 瞬时受体电位通道M2 预后
文献标志码:
A
摘要:
【摘要】 目的 分析动脉瘤性蛛网膜下腔出血(aSAH)患者外周血单个核细胞中瞬时受体电位通道M2(TRPM2)水平与介入治疗预后的关系。方法 选取2019年8月至2021年5月在三亚市中医院接受介入治疗的148例aSAH患者作为研究对象。用Ficoll密度梯度离心法和蛋白质免疫印迹法检测外周血单个核细胞中TRPM2水平。用改良Rankin量表(mRS)评分评价介入治疗90 d后预后。用logistic回归分析TRPM2与aSAH患者介入治疗预后的关系。结果 根据随访后mRS评分将患者分为预后良好组(n=107)和预后不良组(n=41)。预后良好组年龄、Hunt-Hess分级Ⅲ级占比、脑血管痉挛占比和Glasgow昏迷量表(GCS)评分低于预后不良组(均P<0.05)。预后良好组治疗前后TRPM2水平低于预后不良组(均P<0.05)。治疗后TRPM2>0.28和Hunt-Hess分级Ⅲ级是aSAH患者预后的独立危险因素(P<0.05)。结论 aSAH患者介入治疗后TRPM2水平高与预后不良有关。

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备注/Memo

备注/Memo:
(收稿日期:2021- 11- 15)
(本文编辑:边 佶)
更新日期/Last Update: 2022-09-02