[1]叶 娟,尚海龙,沈海林,等.DSA引导下食蟹猴大脑中动脉栓塞模型的建立与评价[J].介入放射学杂志,2022,31(04):369-373.
YE Juan,SHANG Hailong,SHEN Hailin,et al.Establishment of DSA-guided middle cerebral artery embolization mode in cynomolgus monkeys and its technical evaluation[J].journal interventional radiology,2022,31(04):369-373.
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DSA引导下食蟹猴大脑中动脉栓塞模型的建立与评价(
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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31
- 期数:
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2022年04
- 页码:
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369-373
- 栏目:
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实验研究
- 出版日期:
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2022-06-15
文章信息/Info
- Title:
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Establishment of DSA-guided middle cerebral artery embolization mode in cynomolgus monkeys and its technical evaluation
- 作者:
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叶 娟; 尚海龙; 沈海林; 杜红娣; 沈 萍; 朱 枫; 邱志富; 曹 莹; 赵芳红; 王 莺
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- Author(s):
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YE Juan; SHANG Hailong; SHEN Hailin; DU Hongdi; SHEN Ping; ZHU Feng; QIU Zhifu; CAO Ying; ZHAO Fanghong; WANG Ying.
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Department of Medical Imaging, Suzhou Kowloon Hospital, School of Medicine, Shanghai Jiao Tong University, Suzhou, Jiangsu Province 215028, China
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- 关键词:
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【关键词】 食蟹猴; DSA导引; 大脑中动脉闭塞; 动物模型; 影像评价
- 文献标志码:
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A
- 摘要:
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【摘要】 目的 建立并评价DSA导引下食蟹猴大脑中动脉闭塞(MCAO)模型。方法 纳入15只成年雄性食蟹猴。DSA导引下经股动脉切开通过导管向大脑中动脉(MCA)注入猴自体静脉血栓凝块构建MCAO模型。术后分别行颅脑MRI和头颈部CTA+CT灌注(CTP)检查,以明确MCA梗塞后影像学变化。术后7 d连续观察实验猴行为表现,于术后第8天处死,取脑组织行三苯基四唑氯染色。 结果 15只实验猴中1只术前头颈部CTA提示颅内血管畸形,未行手术。14只接受手术的猴中12只经DSA、头颈部CTA+CTP及颅脑MRA扫描证实MCA闭塞成功;1只术中死亡;另1只栓塞后DSA及CT、MRI扫描均显示无明显缺血,麻醉复苏后无脑缺血行为表现。12只实验猴术后均存活,神经功能评分提示有神经功能缺损,其缺损变化与影像学改变相符。结论 DSA导引下将自体静脉血栓引入MCA建立的食蟹猴MCAO模型具有手术创伤小、可重复性高、稳定性强的特点。
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备注/Memo
- 备注/Memo:
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(收稿日期:2021- 09- 12)
(本文编辑:边 佶)
更新日期/Last Update:
2022-05-11