[1]李 岩,黎海亮,陈呈世,等.局部介入联合卡瑞利珠单抗与阿帕替尼治疗转移性软组织肉瘤的安全性和有效性[J].介入放射学杂志,2021,30(11):1123-1127.
 LI Yan,LI Hailiang,CHEN Chengshi,et al.Local intervention combined with camrelizumab and apatinib for the treatment of metastatic soft tissue sarcoma: analysis of its safety and curative effectiveness[J].journal interventional radiology,2021,30(11):1123-1127.
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局部介入联合卡瑞利珠单抗与阿帕替尼治疗转移性软组织肉瘤的安全性和有效性()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
30
期数:
2021年11
页码:
1123-1127
栏目:
肿瘤介入
出版日期:
2021-11-25

文章信息/Info

Title:
Local intervention combined with camrelizumab and apatinib for the treatment of metastatic soft tissue sarcoma: analysis of its safety and curative effectiveness
作者:
李 岩 黎海亮 陈呈世 胡鸿涛 赵 妍
Author(s):
LI Yan LI Hailiang CHEN Chengshi HU Hongtao ZHAO Yan
Department of Minimally- Invasive Intervention, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province 450008, China
关键词:
【关键词】 软组织肉瘤 动脉化疗栓塞术 冷冻消融 免疫治疗 卡瑞利珠单抗 阿帕替尼
文献标志码:
A
摘要:
【摘要】 目的 探讨局部介入联合卡瑞利珠单抗与阿帕替尼治疗转移性软组织肉瘤的安全性与有效性。方法 选取2019年3月至2020年6月收治的15例转移性软组织肉瘤患者,于局部介入后行卡瑞利珠单抗联合阿帕替尼治疗,采用Kaplan- Meier法绘制生存曲线,统计患者中位总生存期(mOS)、中位无进展生存期(mPFS)。临床疗效评估根据改良实体瘤评价标准(mRECIST),计算客观缓解率(ORR )、临床受益率(CBR)、临床获益持续时间(DoCB)并随访观察安全性。结果 15例患者中1例CR、5例PR、7例SD、2例PD,mOS为14.9个月、mPFS为7.8个月、中位DoCB为8.4个月,ORR为40%,CBR为86.7%。Ⅲ级不良反应为贫血2例、高血压2例和白细胞减少1例,未观察到Ⅳ级不良反应。 结论 局部介入联合卡瑞利珠单抗与阿帕替尼能够显著延长转移性软组织肉瘤患者的生存期,且安全可控。

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备注/Memo

备注/Memo:
(收稿日期:2021- 02- 01)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2021-11-22