[1]李 爽,王建民,胡沛霖.颈动脉支架植入术后血清长链非编码RNA结直肠肿瘤差异表达基因水平及临床意义 [J].介入放射学杂志,2021,30(07):707-710.
LI Shuang,WANG Jianmin,HU Peilin..Serum long-chain non-coding RNA colorectal tumor differentially expressed level after carotid artery stenting and its clinical significance[J].journal interventional radiology,2021,30(07):707-710.
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颈动脉支架植入术后血清长链非编码RNA结直肠肿瘤差异表达基因水平及临床意义
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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30
- 期数:
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2021年07
- 页码:
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707-710
- 栏目:
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临床研究
- 出版日期:
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2021-07-29
文章信息/Info
- Title:
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Serum long-chain non-coding RNA colorectal tumor differentially expressed level after carotid artery stenting and its clinical significance
- 作者:
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李 爽; 王建民; 胡沛霖
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- Author(s):
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LI Shuang; WANG Jianmin; HU Peilin.
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Division I, Department of Neurology, Xingtai Municipal People’s Hospital, Xingtai, Hebei Province 054000, China
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- 关键词:
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【关键词】 颈动脉支架植入术; 长链非编码RNA结直肠肿瘤差异表达基因; 预后
- 文献标志码:
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A
- 摘要:
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【摘要】 目的 探讨颈动脉支架植入术后血清长链非编码RNA(LncRNA)结直肠肿瘤差异表达基因(CRNDE)水平及临床意义。 方法 选取2018年1月至2019年6月在邢台市人民医院接受颈动脉支架植入术治疗的173例颈动脉狭窄性急性缺血性脑卒中(AIS)患者作为研究对象。采用实时荧光定量聚合酶链反应(RT-qPCR)法检测患者血清LncRNA CRNDE相对表达量,并分析其与预后的关系。 结果 173例颈动脉狭窄性AIS患者支架植入术后预后不良发生率为39.88%(69/173)。预后不良组患者血清LncRNA CRNDE相对表达量为(1.35±0.34)%,显著高于预后良好组[(0.93±0.19)%](P<0.001)。Logistic回归分析显示,出血转化、脑卒中病灶数、LncRNA CRNDE与颈动脉狭窄性AIS患者预后关系密切。模型B(出血转化+脑卒中病灶数+LncRNA CRNDE)评估颈动脉狭窄性AIS患者预后的效能,高于LncRNA CRNDE、模型A(出血转化+脑卒中病灶数)(Z=2.603,P=0.009;Z=2.945,P=0.003)。 结论 LncRNA CRNDE与颈动脉狭窄性AIS患者支架植入术后预后关系密切,检测血清LncRNA CRNDE表达有助于评估患者预后。
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备注/Memo
- 备注/Memo:
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(收稿日期:2020- 11- 18)
(本文编辑:边 佶)
更新日期/Last Update:
2021-07-28